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CAEEL:O16720

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) No Information Provided.
Protein Name(s) Protein argonaute (ECO:0000256 with RuleBase:RU361178)
External Links
UniProt O16720
EMBL FO081675
RefSeq NP_871992.1
UniGene Cel.38785
ProteinModelPortal O16720
SMR O16720
IntAct O16720
STRING 6239.T07D3.7a
PaxDb O16720
PRIDE O16720
EnsemblMetazoa T07D3.7a
GeneID 173468
KEGG cel:CELE_T07D3.7
UCSC T07D3.7a
CTD 3355106
WormBase T07D3.7a
eggNOG NOG279895
GeneTree ENSGT00760000119148
HOGENOM HOG000116043
InParanoid O16720
KO K11593
OMA KERTIGR
PhylomeDB O16720
Reactome REACT_182979
REACT_183789
REACT_258001
NextBio 879789
Proteomes UP000001940
ExpressionAtlas O16720
GO GO:0005737
GO:0035068
GO:0035198
GO:0009790
GO:0031047
GO:0002119
Gene3D 3.30.420.10
InterPro IPR014811
IPR003100
IPR003165
IPR012337
Pfam PF08699
PF02170
PF02171
SMART SM00949
SM00950
SUPFAM SSF101690
SSF53098
PROSITE PS50821
PS50822

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002119

nematode larval development

PMID:11461699[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00000105

P

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003165
InterPro:IPR012337

F

Seeded From UniProt

complete

GO:0003725

double-stranded RNA binding

PMID:22904066[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0070551

endoribonuclease activity, cleaving siRNA-paired mRNA

PMID:22904066[2]

IDA: Inferred from Direct Assay

F

Figure 1

complete
CACAO 7215

GO:0003727

single-stranded RNA binding

PMID:22904066[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:17381296[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0009792

embryo development ending in birth or egg hatching

PMID:11461699[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00000105

P

Seeded From UniProt

complete

GO:0016892

endoribonuclease activity, producing 3'-phosphomonoesters

PMID:22904066[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0031047

gene silencing by RNA

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0943

P

Seeded From UniProt

complete

GO:0035068

micro-ribonucleoprotein complex

PMID:15024405[4]

IPI: Inferred from Physical Interaction

WB:WBGene00000105
WB:WBGene00002285

C

Seeded From UniProt

complete

GO:0035196

production of miRNAs involved in gene silencing by miRNA

PMID:22904066[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035198

miRNA binding

PMID:19734881[5]

IPI: Inferred from Physical Interaction

WB:WBGene00002285

F

Seeded From UniProt

complete

GO:0035279

mRNA cleavage involved in gene silencing by miRNA

PMID:22904066[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0070551

endoribonuclease activity, cleaving siRNA-paired mRNA

PMID:22904066[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0070922

small RNA loading onto RISC

PMID:22904066[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

PMID:22904066[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Grishok, A et al. (2001) Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106 23-34 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Bouasker, S & Simard, MJ (2012) The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans. Nucleic Acids Res. 40 10452-62 PubMed GONUTS page
  3. Tops, BB et al. (2006) The Caenorhabditis elegans Argonautes ALG-1 and ALG-2: almost identical yet different. Cold Spring Harb. Symp. Quant. Biol. 71 189-94 PubMed GONUTS page
  4. Hutvágner, G et al. (2004) Sequence-specific inhibition of small RNA function. PLoS Biol. 2 E98 PubMed GONUTS page
  5. Chatterjee, S & Grosshans, H (2009) Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature 461 546-9 PubMed GONUTS page