Category:GO:0070922 ! RISC complex assembly

name: RISC complex assembly
namespace: biological_process
alt_id: GO:0035087
alt_id: GO:0035280
alt_id: GO:0070923
def: "The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing complement complex that mediates gene silencing by small RNA." [PMID:14512631, PMID:14744438, PMID:19239886, PMID:22233755, PMID:27184117]
synonym: "gene silencing by RNA, small RNA loading onto RISC" RELATED [GOC:mah]
synonym: "miRISC assembly" BROAD []
synonym: "miRNA loading onto RISC" NARROW []
synonym: "RISC assembly" RELATED [GOC:mah]
synonym: "siRNA loading onto RISC involved in gene silencing by small RNA" NARROW []
synonym: "siRNA loading onto RISC involved in RNA interference" NARROW []
synonym: "small RNA loading onto RISC" RELATED []
is_a: GO:0022618 ! protein-RNA complex assembly
relationship: part_of: GO:0031047 ! regulatory ncRNA-mediated gene silencing

AmiGO <GOterm>GO:0070922</GOterm>
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