ARATH:RAR1

Species (Taxon ID)	Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s)	RAR1 (synonyms: PBS2, RPR2)
Protein Name(s)	Cysteine and histidine-rich domain-containing protein RAR1 AtRAR1 CHORD domain-containing protein RAR1 Protein PPHB SUSCEPTIBLE 2 Protein REQUIRED FOR MLA12 RESISTANCE 1
External Links
UniProt	Q9SE33
EMBL	AF192262 AB010074 CP002688 AY088919
RefSeq	NP_568762.6
UniGene	At.9103
PDB	2XCM
PDBsum	2XCM
ProteinModelPortal	Q9SE33
SMR	Q9SE33
BioGrid	20489
DIP	DIP-41228N
IntAct	Q9SE33
MINT	MINT-232429
PaxDb	Q9SE33
PRIDE	Q9SE33
EnsemblPlants	AT5G51700.1
GeneID	835244
KEGG	ath:AT5G51700
TAIR	AT5G51700
eggNOG	NOG282821
HOGENOM	HOG000265320
InParanoid	Q9SE33
KO	K13458
OMA	QRIGCNA
PhylomeDB	Q9SE33
EvolutionaryTrace	Q9SE33
PRO	PR:Q9SE33
Proteomes	UP000006548
ExpressionAtlas	Q9SE33
Genevestigator	Q9SE33
GO	GO:0051879 GO:0008270 GO:0042742 GO:0009816 GO:0009817 GO:0009626 GO:0050821 GO:0002679
InterPro	IPR007051
Pfam	PF04968
PROSITE	PS51401

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0051879	Hsp90 protein binding	PMID:14504384^[1]	ECO:0000021		UniProtKB:P27323	F	Fig. 1B shows that both HvRAR1 (RAR1 from barley) and AtRAR1 (RAR1 from Arabidopsis) interact with HvHSP90 (HSP90 from barley); the HSP90-binding function is likely conserved between monocots and dicots. The first paragraph of the Results section ("RAR1 Interacts with HSP90") mentions how the authors found using a yeast two-hybrid screen of Arabidopsis that Arabidopsis HSP90.1 (AtHSP90.1) also interacts with RAR1 (data not shown).	complete CACAO 7867
	GO:0005515	protein binding	PMID:11847307^[2]	ECO:0000021		UniProtKB:Q9SUR9 UniProtKB:Q9SUT5	F	Fig. 1C shows that AtRAR1 (RAR1 from Arabidopsis) interacts with AtSGT1a and AtSGT1b (SGT1a and SGT1b from Arabidopsis, respectively) using a yeast two-hybrid screen of Arabidopsis.	complete CACAO 7869
enables	GO:0051879	Hsp90 protein binding	PMID:14504384^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27323	F	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:14592967^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55737	F	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:17148606^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:17279625^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009817	defense response to fungus, incompatible interaction	PMID:12034893^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009817	defense response to fungus, incompatible interaction	PMID:12034891^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009816	defense response to bacterium, incompatible interaction	PMID:12034893^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009816	defense response to bacterium, incompatible interaction	PMID:12034891^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009626	plant-type hypersensitive response	PMID:12034893^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009626	plant-type hypersensitive response	PMID:12034891^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:17279625^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002679	respiratory burst involved in defense response	PMID:12034893^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002679	respiratory burst involved in defense response	PMID:12034891^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:15976272^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:10224270^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009817	defense response to fungus, incompatible interaction	PMID:10224270^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:17279625^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002936451 TAIR:locus:2165316 UniProtKB:Q6EPW7	F	Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002936451 UniProtKB:Q6EPW7	P	Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002936451 TAIR:locus:2165316 UniProtKB:Q6EPW7	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002936451 UniProtKB:Q6EPW7	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002936451 UniProtKB:Q6EPW7	C	Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0611	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Takahashi, A et al. (2003) HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 100 11777-82 PubMed GONUTS page
↑ Azevedo, C et al. (2002) The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science 295 2073-6 PubMed GONUTS page
↑ Hubert, DA et al. (2003) Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein. EMBO J. 22 5679-89 PubMed GONUTS page
↑ Shang, Y et al. (2006) RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB. Proc. Natl. Acad. Sci. U.S.A. 103 19200-5 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Heise, CT et al. (2007) Biochemical characterization of RAR1 cysteine- and histidine-rich domains (CHORDs): a novel class of zinc-dependent protein-protein interaction modules. Biochemistry 46 1612-23 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Tornero, P et al. (2002) RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Plant Cell 14 1005-15 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Muskett, PR et al. (2002) Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Plant Cell 14 979-92 PubMed GONUTS page
↑ Holt, BF 3rd et al. (2005) Antagonistic control of disease resistance protein stability in the plant immune system. Science 309 929-32 PubMed GONUTS page
↑ ^9.0 ^9.1 Warren, RF et al. (1999) Identification of three putative signal transduction genes involved in R gene-specified disease resistance in Arabidopsis. Genetics 152 401-12 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14504384-1] 1.0 ^1.1 Takahashi, A et al. (2003) HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 100 11777-82 PubMed GONUTS page

[PMID:11847307-2] Azevedo, C et al. (2002) The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science 295 2073-6 PubMed GONUTS page

[PMID:14592967-3] Hubert, DA et al. (2003) Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein. EMBO J. 22 5679-89 PubMed GONUTS page

[PMID:17148606-4] Shang, Y et al. (2006) RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB. Proc. Natl. Acad. Sci. U.S.A. 103 19200-5 PubMed GONUTS page

[PMID:17279625-5] 5.0 ^5.1 ^5.2 Heise, CT et al. (2007) Biochemical characterization of RAR1 cysteine- and histidine-rich domains (CHORDs): a novel class of zinc-dependent protein-protein interaction modules. Biochemistry 46 1612-23 PubMed GONUTS page

[PMID:12034893-6] 6.0 ^6.1 ^6.2 ^6.3 Tornero, P et al. (2002) RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed. Plant Cell 14 1005-15 PubMed GONUTS page

[PMID:12034891-7] 7.0 ^7.1 ^7.2 ^7.3 Muskett, PR et al. (2002) Arabidopsis RAR1 exerts rate-limiting control of R gene-mediated defenses against multiple pathogens. Plant Cell 14 979-92 PubMed GONUTS page

[PMID:15976272-8] Holt, BF 3rd et al. (2005) Antagonistic control of disease resistance protein stability in the plant immune system. Science 309 929-32 PubMed GONUTS page

[PMID:10224270-9] 9.0 ^9.1 Warren, RF et al. (1999) Identification of three putative signal transduction genes involved in R gene-specified disease resistance in Arabidopsis. Genetics 152 401-12 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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ARATH:RAR1

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