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PMID:11847307
| Citation |
Azevedo, C, Sadanandom, A, Kitagawa, K, Freialdenhoven, A, Shirasu, K and Schulze-Lefert, P (2002) The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Science 295:2073-6 |
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| Abstract |
Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination. |
| Links |
PubMed Online version:10.1126/science.1067554 |
| Keywords |
Amino Acid Motifs; Amino Acid Sequence; Arabidopsis/chemistry; Arabidopsis/genetics; Arabidopsis/metabolism; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Cycle Proteins/chemistry; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Gene Silencing; Genes, Fungal; Genes, Plant; Hordeum/chemistry; Hordeum/genetics; Hordeum/metabolism; Immunity, Innate; Molecular Sequence Data; Multiprotein Complexes; Peptide Hydrolases; Peptide Synthases/metabolism; Plant Diseases; Plant Proteins/genetics; Plant Proteins/metabolism; Protein Structure, Tertiary; Proteins/metabolism; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; SKP Cullin F-Box Protein Ligases; Saccharomyces cerevisiae Proteins/chemistry; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Sequence Alignment; Signal Transduction; Two-Hybrid System Techniques; Ubiquitin/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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