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PMID:15976272
| Citation |
Holt, BF 3rd, Belkhadir, Y and Dangl, JL (2005) Antagonistic control of disease resistance protein stability in the plant immune system. Science 309:929-32 |
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| Abstract |
Pathogen recognition by the plant immune system is governed by structurally related, polymorphic products of disease resistance (R) genes. RAR1 and/or SGT1b mediate the function of many R proteins. RAR1 controls preactivation R protein accumulation by an unknown mechanism. We demonstrate that Arabidopsis SGT1b has two distinct, genetically separable functions in the plant immune system: SGT1b antagonizes RAR1 to negatively regulate R protein accumulation before infection, and SGT1b has a RAR1-independent function that regulates programmed cell death during infection. The balanced activities of RAR1 and SGT1, in concert with cytosolic HSP90, modulate preactivation R protein accumulation and signaling competence. |
| Links |
PubMed Online version:10.1126/science.1109977 |
| Keywords |
Apoptosis; Arabidopsis/immunology; Arabidopsis/microbiology; Arabidopsis Proteins/genetics; Arabidopsis Proteins/immunology; Arabidopsis Proteins/physiology; Carrier Proteins/antagonists & inhibitors; Carrier Proteins/immunology; Carrier Proteins/physiology; Cell Cycle Proteins/immunology; Cell Cycle Proteins/physiology; Genes, Plant; HSP90 Heat-Shock Proteins/immunology; HSP90 Heat-Shock Proteins/physiology; Mutation; Peronospora/physiology; Plant Diseases/microbiology; Plant Proteins/antagonists & inhibitors; Plant Proteins/immunology; Plant Proteins/physiology; Plants, Genetically Modified; Signal Transduction |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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