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YEAST:YAK1
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | YAK1 | |
| Protein Name(s) | Dual specificity protein kinase YAK1 | |
| External Links | ||
| UniProt | P14680 | |
| EMBL | X16056 X87371 Z49417 BK006943 | |
| PIR | A32582 | |
| RefSeq | NP_012394.1 | |
| ProteinModelPortal | P14680 | |
| SMR | P14680 | |
| BioGrid | 33616 | |
| DIP | DIP-1374N | |
| IntAct | P14680 | |
| MINT | MINT-401556 | |
| STRING | 4932.YJL141C | |
| MaxQB | P14680 | |
| PaxDb | P14680 | |
| PeptideAtlas | P14680 | |
| EnsemblFungi | [example_ID YJL141C] | |
| GeneID | 853300 | |
| KEGG | sce:YJL141C | |
| CYGD | YJL141c | |
| SGD | S000003677 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000119032 | |
| HOGENOM | HOG000170931 | |
| InParanoid | P14680 | |
| KO | K18670 | |
| OMA | RECLIHF | |
| OrthoDB | EOG7WDNBB | |
| BioCyc | YEAST:G3O-31586-MONOMER | |
| BRENDA | 2.7.12.1 | |
| NextBio | 973618 | |
| Proteomes | UP000002311 | |
| Genevestigator | P14680 | |
| GO | GO:0005737 GO:0005634 GO:0005524 GO:0004672 GO:0004674 GO:0004712 GO:0004713 GO:0018108 GO:0006468 | |
| InterPro | IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 | |
| Pfam | PF00069 | |
| SMART | SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig 2a: expression of Yak1 resulted in higher FLO11 RNA levels in both wildtype and mutants (doesn't express Whi3) |
complete | ||||
| GO:0010811 |
positive regulation of cell-substrate adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig 2D |
complete | ||||
| GO:0032106 |
positive regulation of response to extracellular stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Fig 4a: Glucose starvation in wildtype led to increased levels of FLO11 RNA. Mutants without yak1 did not have increased levels of FLO11. |
complete | ||||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P10961) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:P10961) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061408 |
positive regulation of transcription from RNA polymerase II promoter in response to heat stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:P06115) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061408 |
positive regulation of transcription from RNA polymerase II promoter in response to heat stress |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001861 |
P |
has_input:(UniProtKB:P06115) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0061406 |
positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:P53286) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061406 |
positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:P15992) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061406 |
positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:P06115) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061406 |
positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001861 |
P |
has_input:(UniProtKB:P53286) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0061406 |
positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001861 |
P |
has_input:(UniProtKB:P15992) |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0010811 |
positive regulation of cell-substrate adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004712 |
protein serine/threonine/tyrosine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Malcher, M et al. (2011) The Yak1 protein kinase lies at the center of a regulatory cascade affecting adhesive growth and stress resistance in Saccharomyces cerevisiae. Genetics 187 717-30 PubMed GONUTS page
- ↑ 2.0 2.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Lee, P et al. (2013) Rim15-dependent activation of Hsf1 and Msn2/4 transcription factors by direct phosphorylation in Saccharomyces cerevisiae. FEBS Lett. 587 3648-55 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Lee, P et al. (2011) Regulation of yeast Yak1 kinase by PKA and autophosphorylation-dependent 14-3-3 binding. Mol. Microbiol. 79 633-46 PubMed GONUTS page
- ↑ 5.0 5.1 Garrett, S et al. (1991) The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle. Mol. Cell. Biol. 11 4045-52 PubMed GONUTS page
- ↑ 6.0 6.1 Moriya, H et al. (2001) Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal. Genes Dev. 15 1217-28 PubMed GONUTS page
d
f
o
- GO:0032106 ! obsolete positive regulation of response to extracellular stimulus
- GO:0061408 ! obsolete positive regulation of transcription from RNA polymerase II promoter in response to heat stress
- GO:0061406 ! obsolete positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation
p
- GO:0018108 ! peptidyl-tyrosine phosphorylation
- GO:0016310 ! phosphorylation
- GO:0010811 ! positive regulation of cell-substrate adhesion
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004712 ! protein serine/threonine/tyrosine kinase activity
- GO:0004674 ! protein serine/threonine kinase activity
- GO:0004713 ! protein tyrosine kinase activity
s
