YEAST:SWI3

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	SWI3 (synonyms: TYE2)
Protein Name(s)	SWI/SNF complex subunit SWI3 Transcription factor TYE2 Transcription regulatory protein SWI3
External Links
UniProt	P32591
EMBL	M84390 X56792 Z49451 BK006943
PIR	S26706
RefSeq	NP_012359.1
PDB	2FQ3
PDBsum	2FQ3
ProteinModelPortal	P32591
SMR	P32591
BioGrid	33585
DIP	DIP-2471N
IntAct	P32591
MINT	MINT-563159
STRING	4932.YJL176C
MaxQB	P32591
PaxDb	P32591
PeptideAtlas	P32591
EnsemblFungi	[example_ID YJL176C]
GeneID	853264
KEGG	sce:YJL176C
CYGD	YJL176c
SGD	S000003712
eggNOG	COG5259
GeneTree	ENSGT00390000018166
HOGENOM	HOG000142068
InParanoid	P32591
KO	K11772
OrthoDB	EOG7ZWDBR
BioCyc	YEAST:G3O-31611-MONOMER
EvolutionaryTrace	P32591
NextBio	973526
Proteomes	UP000002311
Genevestigator	P32591
GO	GO:0005829 GO:0005634 GO:0016514 GO:0003682 GO:0003677 GO:0042393 GO:0006200 GO:0043044 GO:0000436 GO:0044109 GO:0031496 GO:0045944 GO:0005987 GO:0006351
Gene3D	1.10.10.10 1.10.10.60
InterPro	IPR009057 IPR001005 IPR017884 IPR007526 IPR011991
Pfam	PF00249 PF04433
SMART	SM00717
SUPFAM	SSF46689
PROSITE	PS51293 PS50934

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0000076	DNA replication checkpoint	PMID:20967229^[1]	ECO:0000315			P		fig:1	complete
	GO:0005657	replication fork	PMID:20967229^[1]	ECO:0000315			C		fig; 1	complete
	GO:0006281	DNA repair	PMID:20967229^[1]	ECO:0000315			P		fig: 6	complete
	GO:0031297	replication fork processing	PMID:20967229^[1]	ECO:0000315			P		fig: 5	complete
	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:20967229^[1]	ECO:0000315			P		fig: 6	complete
	GO:0007062	sister chromatid cohesion	PMID:20967229^[1]	ECO:0000315			P		fig: 7	complete
	GO:0042262	DNA protection	PMID:20967229^[1]	ECO:0000315			P		fig: 1, 6, 7.	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:3542227^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:1339306^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044109	cellular alcohol catabolic process	PMID:1339306^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043044	ATP-dependent chromatin remodeling	PMID:8016655^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:17496903^[5]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000000098 SGD:S000000099 SGD:S000002632 SGD:S000002633	F		Seeded From UniProt	complete
involved_in	GO:0031496	positive regulation of mating type switching	PMID:6436497^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	PMID:8159677^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	PMID:8127913^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	PMID:18644858^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	PMID:8159677^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016514	SWI/SNF complex	PMID:8016655^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0015616	DNA translocase activity	PMID:17188033^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0005987	sucrose catabolic process	PMID:1339306^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22932476^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071456)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:1339306^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22932476^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16461455^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16461455^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000436	carbon catabolite activation of transcription from RNA polymerase II promoter	PMID:8221926^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009057	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Rapp, JB et al. (2010) Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast. PLoS ONE 5 e13379 PubMed GONUTS page
↑ Breeden, L & Nasmyth, K (1987) Cell cycle control of the yeast HO gene: cis- and trans-acting regulators. Cell 48 389-97 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Peterson, CL & Herskowitz, I (1992) Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription. Cell 68 573-83 PubMed GONUTS page
↑ ^4.0 ^4.1 Côté, J et al. (1994) Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Science 265 53-60 PubMed GONUTS page
↑ Yang, X et al. (2007) Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement. Nat. Struct. Mol. Biol. 14 540-7 PubMed GONUTS page
↑ Stern, M et al. (1984) Five SWI genes are required for expression of the HO gene in yeast. J. Mol. Biol. 178 853-68 PubMed GONUTS page
↑ ^7.0 ^7.1 Peterson, CL et al. (1994) Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement. Proc. Natl. Acad. Sci. U.S.A. 91 2905-8 PubMed GONUTS page
↑ Cairns, BR et al. (1994) A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast. Proc. Natl. Acad. Sci. U.S.A. 91 1950-4 PubMed GONUTS page
↑ Dechassa, ML et al. (2008) Architecture of the SWI/SNF-nucleosome complex. Mol. Cell. Biol. 28 6010-21 PubMed GONUTS page
↑ Zhang, Y et al. (2006) DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Mol. Cell 24 559-68 PubMed GONUTS page
↑ ^11.0 ^11.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page
↑ ^12.0 ^12.1 Da, G et al. (2006) Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Proc. Natl. Acad. Sci. U.S.A. 103 2057-62 PubMed GONUTS page
↑ Löhning, C et al. (1993) Isolation of the TYE2 gene reveals its identity to SWI3 encoding a general transcription factor in Saccharomyces cerevisiae. Curr. Genet. 24 193-9 PubMed GONUTS page

[PMID:20967229-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Rapp, JB et al. (2010) Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast. PLoS ONE 5 e13379 PubMed GONUTS page

[PMID:3542227-2] Breeden, L & Nasmyth, K (1987) Cell cycle control of the yeast HO gene: cis- and trans-acting regulators. Cell 48 389-97 PubMed GONUTS page

[PMID:1339306-3] 3.0 ^3.1 ^3.2 ^3.3 Peterson, CL & Herskowitz, I (1992) Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription. Cell 68 573-83 PubMed GONUTS page

[PMID:8016655-4] 4.0 ^4.1 Côté, J et al. (1994) Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Science 265 53-60 PubMed GONUTS page

[PMID:17496903-5] Yang, X et al. (2007) Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement. Nat. Struct. Mol. Biol. 14 540-7 PubMed GONUTS page

[PMID:6436497-6] Stern, M et al. (1984) Five SWI genes are required for expression of the HO gene in yeast. J. Mol. Biol. 178 853-68 PubMed GONUTS page

[PMID:8159677-7] 7.0 ^7.1 Peterson, CL et al. (1994) Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement. Proc. Natl. Acad. Sci. U.S.A. 91 2905-8 PubMed GONUTS page

[PMID:8127913-8] Cairns, BR et al. (1994) A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast. Proc. Natl. Acad. Sci. U.S.A. 91 1950-4 PubMed GONUTS page

[PMID:18644858-9] Dechassa, ML et al. (2008) Architecture of the SWI/SNF-nucleosome complex. Mol. Cell. Biol. 28 6010-21 PubMed GONUTS page

[PMID:17188033-10] Zhang, Y et al. (2006) DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Mol. Cell 24 559-68 PubMed GONUTS page

[PMID:22932476-11] 11.0 ^11.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page

[PMID:16461455-12] 12.0 ^12.1 Da, G et al. (2006) Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Proc. Natl. Acad. Sci. U.S.A. 103 2057-62 PubMed GONUTS page

[PMID:8221926-13] Löhning, C et al. (1993) Isolation of the TYE2 gene reveals its identity to SWI3 encoding a general transcription factor in Saccharomyces cerevisiae. Curr. Genet. 24 193-9 PubMed GONUTS page

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YEAST:SWI3

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