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PMID:8221926
| Citation |
Löhning, C, Rosenbaum, C and Ciriacy, M (1993) Isolation of the TYE2 gene reveals its identity to SWI3 encoding a general transcription factor in Saccharomyces cerevisiae. Curr. Genet. 24:193-9 |
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| Abstract |
The TYE2 gene was identified by recessive mutations which result in a significant reduction of Ty-mediated ADH2 expression. We cloned the TYE2 gene and analyzed its sequence. A large open reading frame of 825 codons was found encoding a rather hydrophilic, 93-kilodalton protein which contains a highly acidic region at its N-terminus. By sequence comparison we found that TYE2 is identical to gene SWI3 which has recently been shown to encode a nuclear protein which may function as a global transcription activation factor. The TYE2/SWI3 protein is necessary for the initiation of Ty1 transcription at its major initiation site in the delta element. Furthermore TYE2 function seems to be important for the expression of a variety of Ty-unrelated functions such as ADH1 expression, sporulation, growth on maltose, galactose, raffinose, and on non-fermentable carbon sources. |
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| Keywords |
Blotting, Northern; Cloning, Molecular; Fungal Proteins/genetics; Genes, Fungal; Molecular Sequence Data; Mutation; Nuclear Proteins/genetics; Open Reading Frames; Phenotype; Restriction Mapping; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins; Sequence Homology; Trans-Activators/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0000436: carbon catabolite activation of transcription from RNA polymerase II promoter |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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