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YEAST:KAPA

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) TPK1 (synonyms: PKA1, SRA3)
Protein Name(s) cAMP-dependent protein kinase type 1

PKA 1 CDC25-suppressing protein kinase PK-25

External Links
UniProt P06244
EMBL M17072
J02665
M17224
Z49439
AY899257
BK006943
PIR JC1034
RefSeq NP_012371.2
PDB 1FOT
PDBsum 1FOT
ProteinModelPortal P06244
SMR P06244
BioGrid 33595
DIP DIP-548N
IntAct P06244
MINT MINT-569684
MaxQB P06244
PaxDb P06244
PeptideAtlas P06244
EnsemblFungi [example_ID YJL164C]
GeneID 853275
KEGG sce:YJL164C
SGD S000003700
eggNOG COG0515
GeneTree ENSGT00770000120454
HOGENOM HOG000233033
InParanoid P06244
KO K04345
OMA KRYGNLH
OrthoDB EOG7R2BT5
BioCyc YEAST:G3O-31604-MONOMER
BRENDA 2.7.11.11
Reactome REACT_229657
REACT_235985
REACT_237720
REACT_237834
REACT_239269
REACT_243583
REACT_257022
REACT_270118
EvolutionaryTrace P06244
NextBio 973556
PRO PR:P06244
Proteomes UP000002311
Genevestigator P06244
GO GO:0005952
GO:0005737
GO:0005634
GO:0005524
GO:0004691
GO:0007049
GO:0051301
GO:0010737
GO:0006468
GO:0007265
InterPro IPR000961
IPR011009
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00133
SM00220
SUPFAM SSF56112
PROSITE PS51285
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0004672

protein kinase activity

PMID:16319894[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:16319894[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010607

negative regulation of cytoplasmic mRNA processing body assembly

PMID:21925385[2]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000001649,SGD:S000006124

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21925385[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_input:(UniProtKB:P25644)

Seeded From UniProt

complete

involved_in

GO:0016241

regulation of macroautophagy

PMID:15016820[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:26403272[4]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0071470)

Seeded From UniProt

complete

involved_in

GO:0010737

protein kinase A signaling

PMID:20133652[5]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000001649
SGD:S000006124

P

Seeded From UniProt

complete

involved_in

GO:0007265

Ras protein signal transduction

PMID:3036373[6]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003542
SGD:S000004301
SGD:S000005042
SGD:S000005627

P

Seeded From UniProt

complete

involved_in

GO:0007265

Ras protein signal transduction

PMID:2823100[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:3036373[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:3036373[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005952

cAMP-dependent protein kinase complex

PMID:12024012[8]

ECO:0000353

physical interaction evidence used in manual assertion

SGD:S000001295

C

Seeded From UniProt

complete

part_of

GO:0005952

cAMP-dependent protein kinase complex

PMID:3036373[6]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000001295

C

Seeded From UniProt

complete

part_of

GO:0005952

cAMP-dependent protein kinase complex

PMID:12024012[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10625697[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10625697[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004691

cAMP-dependent protein kinase activity

PMID:3036373[6]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003542
SGD:S000004301
SGD:S000005042
SGD:S000005627

F

Seeded From UniProt

complete

enables

GO:0004691

cAMP-dependent protein kinase activity

PMID:3036373[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004691

cAMP-dependent protein kinase activity

PMID:3036373[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000961

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0004691

cAMP-dependent protein kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.11

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page
  2. ↑ 2.0 2.1 Ramachandran, V et al. (2011) The cAMP-dependent protein kinase signaling pathway is a key regulator of P body foci formation. Mol. Cell 43 973-81 PubMed GONUTS page
  3. ↑ Budovskaya, YV et al. (2004) The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae. J. Biol. Chem. 279 20663-71 PubMed GONUTS page
  4. ↑ Baccarini, L et al. (2015) PKA-chromatin association at stress responsive target genes from Saccharomyces cerevisiae. Biochim. Biophys. Acta 1849 1329-39 PubMed GONUTS page
  5. ↑ Popova, Y et al. (2010) Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor. Proc. Natl. Acad. Sci. U.S.A. 107 2890-5 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Toda, T et al. (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50 277-87 PubMed GONUTS page
  7. ↑ Cannon, JF & Tatchell, K (1987) Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase. Mol. Cell. Biol. 7 2653-63 PubMed GONUTS page
  8. ↑ 8.0 8.1 Pan, X & Heitman, J (2002) Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. Mol. Cell. Biol. 22 3981-93 PubMed GONUTS page
  9. ↑ 9.0 9.1 Griffioen, G et al. (2000) Nutritional control of nucleocytoplasmic localization of cAMP-dependent protein kinase catalytic and regulatory subunits in Saccharomyces cerevisiae. J. Biol. Chem. 275 1449-56 PubMed GONUTS page
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