GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:3036373
| Citation |
Toda, T, Cameron, S, Sass, P, Zoller, M and Wigler, M (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50:277-87 |
|---|---|
| Abstract |
We have isolated three genes (TPK1, TPK2, and TPK3) from the yeast S. cerevisiae that encode the catalytic subunits of the cAMP-dependent protein kinase. Gene disruption experiments demonstrated that no two of the three genes are essential by themselves but at least one TPK gene is required for a cell to grow normally. Comparison of the predicted amino acid sequences of the TPK genes indicates conserved and variable domains. The carboxy-terminal 320 amino acid residues have more than 75% homology to each other and more than 50% homology to the bovine catalytic subunit. The amino-terminal regions show no homology to each other and are heterogeneous in length. The TPK1 gene carried on a multicopy plasmid can suppress both a temperature-sensitive ras2 gene and adenylate cyclase gene. |
| Links | |
| Keywords |
Amino Acid Sequence; Base Sequence; DNA Restriction Enzymes; Genes; Genes, Fungal; Genotype; Macromolecular Substances; Plasmids; Protein Kinases/genetics; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
