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YEAST:HST2

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) HST2
Protein Name(s) NAD-dependent protein deacetylase HST2

Homologous to SIR2 protein 2 Regulatory protein SIR2 homolog 2

External Links
UniProt P53686
EMBL U39063
U33335
AY693204
BK006949
PIR S59678
RefSeq NP_015310.1
PDB 1Q14
1Q17
1Q1A
1SZC
1SZD
2OD2
2OD7
2OD9
2QQF
2QQG
PDBsum 1Q14
1Q17
1Q1A
1SZC
1SZD
2OD2
2OD7
2OD9
2QQF
2QQG
ProteinModelPortal P53686
SMR P53686
BioGrid 36162
IntAct P53686
MINT P53686
STRING 4932.YPL015C
BindingDB P53686
ChEMBL CHEMBL5933
iPTMnet P53686
MaxQB P53686
PaxDb P53686
PRIDE P53686
EnsemblFungi YPL015C_mRNA
GeneID 856092
KEGG sce:YPL015C
EuPathDB FungiDB:YPL015C
SGD S000005936
GeneTree ENSGT00940000157514
HOGENOM HOG000085952
InParanoid P53686
KO K11121
OMA PAHYFVR
BioCyc YEAST:G3O-33934-MONOMER
Reactome R-SCE-2151201
R-SCE-9617629
SABIO-RK P53686
EvolutionaryTrace P53686
PRO PR:P53686
Proteomes UP000002311
GO GO:0005737
GO:0005634
GO:0070403
GO:0017136
GO:0046970
GO:0008270
GO:0000183
GO:0001300
GO:0070933
GO:0031939
GO:0045950
Gene3D 3.30.1600.10
InterPro IPR029035
IPR003000
IPR026591
IPR017328
IPR026590
Pfam PF02146
PIRSF PIRSF037938
SUPFAM SSF52467
PROSITE PS50305

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045950

negative regulation of mitotic recombination

PMID:16051752[1]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000002200
SGD:S000002517

P

Seeded From UniProt

involved_in

GO:0045950

negative regulation of mitotic recombination

PMID:16051752[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0031939

negative regulation of chromatin silencing at telomere

PMID:11226170[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:10841563[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:10811920[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:11226170[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005634

nucleus

PMID:17110954[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0001300

chronological cell aging

PMID:16051752[1]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000002200
SGD:S000002517

P

Seeded From UniProt

involved_in

GO:0001300

chronological cell aging

PMID:16051752[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0000183

chromatin silencing at rDNA

PMID:11226170[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0000183

chromatin silencing at rDNA

PMID:16051752[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0070933

histone H4 deacetylation

PMID:16648462[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0046970

NAD-dependent histone deacetylase activity (H4-K16 specific)

PMID:16648462[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

enables

GO:0070403

NAD+ binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000119154
PomBase:SPBC16D10.07c
UniProtKB:Q8IXJ6

F

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0024291
FB:FBgn0038788
MGI:MGI:2135607
PANTHER:PTN000119154
SGD:S000002200
SGD:S000005429
SGD:S000005551
SGD:S000005936
UniProtKB:Q96EB6

F

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0024291
FB:FBgn0038788
MGI:MGI:2135607
PANTHER:PTN000119154
SGD:S000002200
SGD:S000005429
SGD:S000005551
SGD:S000005936
UniProtKB:Q8IXJ6
UniProtKB:Q96EB6

F

Seeded From UniProt

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017328

F

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017328

F

Seeded From UniProt

enables

GO:0070403

NAD+ binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003000

F

Seeded From UniProt

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

involved_in

GO:0045950

negative regulation of mitotic recombination

PMID:16051752[1]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000002200
SGD:S000002517

P

Seeded From UniProt

involved_in

GO:0045950

negative regulation of mitotic recombination

PMID:16051752[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0031939

negative regulation of chromatin silencing at telomere

PMID:11226170[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:10841563[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:10811920[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

part_of

GO:0005737

cytoplasm

PMID:11226170[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005634

nucleus

PMID:17110954[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

involved_in

GO:0001300

chronological cell aging

PMID:16051752[1]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000002200
SGD:S000002517

P

Seeded From UniProt

involved_in

GO:0001300

chronological cell aging

PMID:16051752[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0000183

chromatin silencing at rDNA

PMID:11226170[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0000183

chromatin silencing at rDNA

PMID:16051752[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0070933

histone H4 deacetylation

PMID:16648462[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

enables

GO:0046970

NAD-dependent histone deacetylase activity (H4-K16 specific)

PMID:16648462[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

enables

GO:0070403

NAD+ binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000119154
PomBase:SPBC16D10.07c
UniProtKB:Q8IXJ6

F

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0024291
FB:FBgn0038788
MGI:MGI:2135607
PANTHER:PTN000119154
SGD:S000002200
SGD:S000005429
SGD:S000005551
SGD:S000005936
UniProtKB:Q96EB6

F

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0024291
FB:FBgn0038788
MGI:MGI:2135607
PANTHER:PTN000119154
SGD:S000002200
SGD:S000005429
SGD:S000005551
SGD:S000005936
UniProtKB:Q8IXJ6
UniProtKB:Q96EB6

F

Seeded From UniProt

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017328

F

Seeded From UniProt

enables

GO:0017136

NAD-dependent histone deacetylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017328

F

Seeded From UniProt

enables

GO:0070403

NAD+ binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003000

F

Seeded From UniProt

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

part_of

GO:0005634

nucleus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

part_of

GO:0005737

cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Lamming, DW et al. (2005) HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309 1861-4 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Perrod, S et al. (2001) A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast. EMBO J. 20 197-209 PubMed GONUTS page
  3. ↑ 3.0 3.1 Smith, JS et al. (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. U.S.A. 97 6658-63 PubMed GONUTS page
  4. ↑ 4.0 4.1 Landry, J et al. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. U.S.A. 97 5807-11 PubMed GONUTS page
  5. ↑ 5.0 5.1 Wilson, JM et al. (2006) Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep. 7 1247-51 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Vaquero, A et al. (2006) SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev. 20 1256-61 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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