YEAST:HMO1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	HMO1 (synonyms: HSM2)
Protein Name(s)	High mobility group protein 1 High spontaneous mutagenesis protein 2
External Links
UniProt	Q03973
EMBL	Z46727 AY557680 BK006938
PIR	S49770
RefSeq	NP_010459.1
ProteinModelPortal	Q03973
SMR	Q03973
BioGrid	32227
DIP	DIP-1687N
IntAct	Q03973
MINT	Q03973
STRING	4932.YDR174W
iPTMnet	Q03973
MaxQB	Q03973
PaxDb	Q03973
PRIDE	Q03973
EnsemblFungi	YDR174W
GeneID	851754
KEGG	sce:YDR174W
EuPathDB	FungiDB:YDR174W
SGD	S000002581
HOGENOM	HOG000001040
InParanoid	Q03973
OMA	YILFQNE
OrthoDB	EOG092C5ER2
BioCyc	YEAST:G3O-29763-MONOMER
PRO	PR:Q03973
Proteomes	UP000002311
GO	GO:0005737 GO:0005829 GO:0005730 GO:0005634 GO:0033553 GO:0032040 GO:0008301 GO:0003690 GO:0000400 GO:0030261 GO:0006323 GO:0090579 GO:0060962 GO:0006356 GO:0001174
Gene3D	1.10.30.10
InterPro	IPR009071 IPR036910
Pfam	PF00505
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	PMID:28336179^[1]	ECO:0000315			P		Figure 1B-I, absolute repair efficiency in wild-type DDY3.	complete CACAO 13211
involved_in	GO:0030261	chromosome condensation	PMID:27030801^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0033553	rDNA heterochromatin	PMID:18451108^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001174	transcriptional start site selection at RNA polymerase II promoter	PMID:18187511^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006323	DNA packaging	PMID:25063301^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:25063301^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090579	dsDNA loop formation	PMID:25063301^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060962	regulation of ribosomal protein gene transcription by RNA polymerase II	PMID:18187511^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003506 SGD:S000006290	P		Seeded From UniProt	complete
involved_in	GO:0060962	regulation of ribosomal protein gene transcription by RNA polymerase II	PMID:18187511^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060962	regulation of ribosomal protein gene transcription by RNA polymerase II	PMID:17875934^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032040	small-subunit processome	PMID:22553361^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:15507436^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:16533046^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006356	regulation of transcription by RNA polymerase I	PMID:12374750^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000005192	P		Seeded From UniProt	complete
involved_in	GO:0006356	regulation of transcription by RNA polymerase I	PMID:16612005^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22932476^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071456)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:8969238^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:12374750^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22932476^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:15507436^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:16533046^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0000790	nuclear chromatin	PMID:16612005^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0000790	nuclear chromatin	PMID:17646381^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	PMID:16533046^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	PMID:15507436^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Panday, A et al. (2017) Control of DNA end resection by yeast Hmo1p affects efficiency of DNA end-joining. DNA Repair (Amst.) 53 15-23 PubMed GONUTS page
↑ Panday, A & Grove, A (2016) The high mobility group protein HMO1 functions as a linker histone in yeast. Epigenetics Chromatin 9 13 PubMed GONUTS page
↑ Merz, K et al. (2008) Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules. Genes Dev. 22 1190-204 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Kasahara, K et al. (2008) Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase II. Nucleic Acids Res. 36 1343-57 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Murugesapillai, D et al. (2014) DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin. Nucleic Acids Res. 42 8996-9004 PubMed GONUTS page
↑ Berger, AB et al. (2007) Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription. Mol. Cell. Biol. 27 8015-26 PubMed GONUTS page
↑ Chen, H et al. (2012) The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis. Nucleic Acids Res. 40 6534-46 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Kamau, E et al. (2004) The Saccharomyces cerevisiae high mobility group box protein HMO1 contains two functional DNA binding domains. J. Biol. Chem. 279 55234-40 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Bauerle, KT et al. (2006) Interactions between N- and C-terminal domains of the Saccharomyces cerevisiae high-mobility group protein HMO1 are required for DNA bending. Biochemistry 45 3635-45 PubMed GONUTS page
↑ ^10.0 ^10.1 Gadal, O et al. (2002) Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system. EMBO J. 21 5498-507 PubMed GONUTS page
↑ ^11.0 ^11.1 Hall, DB et al. (2006) An HMG protein, Hmo1, associates with promoters of many ribosomal protein genes and throughout the rRNA gene locus in Saccharomyces cerevisiae. Mol. Cell. Biol. 26 3672-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page
↑ Lu, J et al. (1996) Characterization of a high mobility group 1/2 homolog in yeast. J. Biol. Chem. 271 33678-85 PubMed GONUTS page
↑ Kasahara, K et al. (2007) Assembly of regulatory factors on rRNA and ribosomal protein genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 27 6686-705 PubMed GONUTS page

[PMID:28336179-1] Panday, A et al. (2017) Control of DNA end resection by yeast Hmo1p affects efficiency of DNA end-joining. DNA Repair (Amst.) 53 15-23 PubMed GONUTS page

[PMID:27030801-2] Panday, A & Grove, A (2016) The high mobility group protein HMO1 functions as a linker histone in yeast. Epigenetics Chromatin 9 13 PubMed GONUTS page

[PMID:18451108-3] Merz, K et al. (2008) Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules. Genes Dev. 22 1190-204 PubMed GONUTS page

[PMID:18187511-4] 4.0 ^4.1 ^4.2 Kasahara, K et al. (2008) Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase II. Nucleic Acids Res. 36 1343-57 PubMed GONUTS page

[PMID:25063301-5] 5.0 ^5.1 ^5.2 Murugesapillai, D et al. (2014) DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin. Nucleic Acids Res. 42 8996-9004 PubMed GONUTS page

[PMID:17875934-6] Berger, AB et al. (2007) Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription. Mol. Cell. Biol. 27 8015-26 PubMed GONUTS page

[PMID:22553361-7] Chen, H et al. (2012) The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis. Nucleic Acids Res. 40 6534-46 PubMed GONUTS page

[PMID:15507436-8] 8.0 ^8.1 ^8.2 Kamau, E et al. (2004) The Saccharomyces cerevisiae high mobility group box protein HMO1 contains two functional DNA binding domains. J. Biol. Chem. 279 55234-40 PubMed GONUTS page

[PMID:16533046-9] 9.0 ^9.1 ^9.2 Bauerle, KT et al. (2006) Interactions between N- and C-terminal domains of the Saccharomyces cerevisiae high-mobility group protein HMO1 are required for DNA bending. Biochemistry 45 3635-45 PubMed GONUTS page

[PMID:12374750-10] 10.0 ^10.1 Gadal, O et al. (2002) Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system. EMBO J. 21 5498-507 PubMed GONUTS page

[PMID:16612005-11] 11.0 ^11.1 Hall, DB et al. (2006) An HMG protein, Hmo1, associates with promoters of many ribosomal protein genes and throughout the rRNA gene locus in Saccharomyces cerevisiae. Mol. Cell. Biol. 26 3672-9 PubMed GONUTS page

[PMID:22932476-12] 12.0 ^12.1 Dastidar, RG et al. (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2 30 PubMed GONUTS page

[PMID:8969238-13] Lu, J et al. (1996) Characterization of a high mobility group 1/2 homolog in yeast. J. Biol. Chem. 271 33678-85 PubMed GONUTS page

[PMID:17646381-14] Kasahara, K et al. (2007) Assembly of regulatory factors on rRNA and ribosomal protein genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 27 6686-705 PubMed GONUTS page

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YEAST:HMO1

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