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YEAST:ACON

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) ACO1 (synonyms: GLU1)
Protein Name(s) Aconitate hydratase, mitochondrial

Aconitase Citrate hydro-lyase

External Links
UniProt P19414
EMBL M33131
U17243
BK006945
PIR S50387
RefSeq NP_013407.1
ProteinModelPortal P19414
SMR P19414
BioGrid 31569
DIP DIP-4679N
IntAct P19414
MINT MINT-557728
STRING 4932.YLR304C
MaxQB P19414
PaxDb P19414
PeptideAtlas P19414
PRIDE P19414
EnsemblFungi [example_ID YLR304C]
GeneID 851013
KEGG sce:YLR304C
CYGD YLR304c
SGD S000004295
eggNOG COG1048
GeneTree ENSGT00760000119830
HOGENOM HOG000224293
InParanoid P19414
KO K01681
OMA AVEANKW
OrthoDB EOG7X6M7Q
BioCyc MetaCyc:YLR304C-MONOMER
YEAST:YLR304C-MONOMER
Reactome REACT_189012
REACT_245486
UniPathway UPA00223
NextBio 967571
PRO PR:P19414
Proteomes UP000002311
Genevestigator P19414
GO GO:0005829
GO:0005758
GO:0005759
GO:0042645
GO:0051539
GO:0003994
GO:0003690
GO:0046872
GO:0003697
GO:0000002
GO:0006099
Gene3D 3.20.19.10
3.30.499.10
3.40.1060.10
InterPro IPR015931
IPR015937
IPR001030
IPR015928
IPR015932
IPR018136
IPR006248
IPR000573
PANTHER PTHR11670
Pfam PF00330
PF00694
PRINTS PR00415
SUPFAM SSF52016
SSF53732
TIGRFAMs TIGR01340
PROSITE PS00450
PS01244

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005739

mitochondrion

PMID:16823961[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:24769239[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0042645

mitochondrial nucleoid

PMID:10869431[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:1972545[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15975908[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:15692048[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

PMID:1972545[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

PMID:1972545[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:17698960[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

PMID:17698960[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000002

mitochondrial genome maintenance

PMID:15692048[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
PANTHER:PTN000186533
RGD:621360
UniProtKB:P20004

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010100
PANTHER:PTN000186533
RGD:621360
SGD:S000004295
UniProtKB:Q8ZRS8
UniProtKB:Q99798

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
PANTHER:PTN001705783
SGD:S000004295

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010100
MGI:MGI:87880
PANTHER:PTN000186534
PomBase:SPAC24C9.06c
PomBase:SPBP4H10.15
RGD:621360
UniProtKB:P20004

C

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG12316
MGI:MGI:87880
PANTHER:PTN000186533
RGD:621360
SGD:S000004295
UniProtKB:C8VG90
UniProtKB:P20004
UniProtKB:Q4WLN1
UniProtKB:Q8ZRS8
UniProtKB:Q99798

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006248

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006248

P

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006248

F

Seeded From UniProt

complete

enables

GO:0003994

aconitate hydratase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.1.3

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-SCE-1252255

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005758

mitochondrial intermembrane space

Reactome:R-SCE-1252255

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0816
UniPathway:UPA00223

P

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0004

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  2. ↑ Renvoisé, M et al. (2014) Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae. J Proteomics 106 140-50 PubMed GONUTS page
  3. ↑ Kaufman, BA et al. (2000) In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc. Natl. Acad. Sci. U.S.A. 97 7772-7 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gangloff, SP et al. (1990) Molecular cloning of the yeast mitochondrial aconitase gene (ACO1) and evidence of a synergistic regulation of expression by glucose plus glutamate. Mol. Cell. Biol. 10 3551-61 PubMed GONUTS page
  5. ↑ Regev-Rudzki, N et al. (2005) Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing. Mol. Biol. Cell 16 4163-71 PubMed GONUTS page
  6. ↑ 6.0 6.1 Chen, XJ et al. (2005) Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science 307 714-7 PubMed GONUTS page
  7. ↑ 7.0 7.1 Chen, XJ et al. (2007) Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA. Proc. Natl. Acad. Sci. U.S.A. 104 13738-43 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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