PMID:15692048

Citation	Chen, XJ, Wang, X, Kaufman, BA and Butow, RA (2005) Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science 307:714-7
Abstract	Mitochondrial DNA (mtDNA) is essential for cells to maintain respiratory competency and is inherited as a protein-DNA complex called the nucleoid. We have identified 22 mtDNA-associated proteins in yeast, among which is mitochondrial aconitase (Aco1p). We show that this Krebs-cycle enzyme is essential for mtDNA maintenance independent of its catalytic activity. Regulation of ACO1 expression by the HAP and retrograde metabolic signaling pathways directly affects mtDNA maintenance. When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance.
Links	PubMed Online version:10.1126/science.1106391
Keywords	Alleles; Amino Acid Substitution; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; CCAAT-Binding Factor/genetics; CCAAT-Binding Factor/metabolism; DNA, Fungal/metabolism; DNA, Mitochondrial/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Gene Expression Regulation, Fungal; Genes, Fungal; Glucose/metabolism; Iron Regulatory Protein 1/genetics; Iron Regulatory Protein 1/metabolism; Mutation; Repressor Proteins/genetics; Repressor Proteins/metabolism; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Signal Transduction; Spores, Fungal/physiology; Transcription Factors/genetics; Transcription Factors/metabolism; Transformation, Genetic
edit table

Annotations

Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
edit table

References

See Help:References for how to manage references in GONUTS.