XENLA:FOXH1

Species (Taxon ID)	Xenopus laevis (African clawed frog). (8355)
Gene Name(s)	foxh1 (synonyms: fast-1, fast1, foxh1a)
Protein Name(s)	Forkhead box protein H1 Forkhead activin signal transducer 1 Fast-1 xFAST-1 XFoxH1a
External Links
UniProt	P70056
EMBL	U70980 BC160705
RefSeq	NP_001081820.1
UniGene	Xl.381
ProteinModelPortal	P70056
GeneID	398070
KEGG	xla:398070
CTD	8928
Xenbase	XB-GENE-1194377
HOVERGEN	HBG051646
KO	K09400
GO	GO:0032444 GO:0005634 GO:0043565 GO:0003700 GO:0046332 GO:0008134 GO:0044212 GO:0032924 GO:0001702 GO:0007501 GO:0045944 GO:0045893 GO:0006351 GO:0007179
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0046332	SMAD binding	PMID:14729957^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q91912	F	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:10691736^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q91912	F	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:12050132^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q91912	F	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:9288972^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q91912	F	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:10349617^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11937490^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14729957^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10473623^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10349617^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14729957^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10473623^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10349617^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:11937490^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:10473623^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8878477^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	PMID:11937490^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:12374795^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13485	C	Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:12374795^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q91912	C	Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:9288972^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97471	C	Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:9288972^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q91912	C	Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:8878477^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q91912	C	Seeded From UniProt	complete
part_of	GO:0032444	activin responsive factor complex	PMID:12050132^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:11937490^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B7ZQJ9	F	Seeded From UniProt	complete
involved_in	GO:0007501	mesodermal cell fate specification	PMID:10572039^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:14729957^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:10349617^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8878477^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	PMID:12050132^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75593	P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0306	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Randall, RA et al. (2004) Recognition of phosphorylated-Smad2-containing complexes by a novel Smad interaction motif. Mol. Cell. Biol. 24 1106-21 PubMed GONUTS page
↑ Germain, S et al. (2000) Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev. 14 435-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Howell, M et al. (2002) A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements. Development 129 2823-34 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Chen, X et al. (1997) Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389 85-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Weisberg, E et al. (1998) A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Mech. Dev. 79 17-27 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Ring, C et al. (2002) The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev. 16 820-35 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Yeo, CY et al. (1999) The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis. J. Biol. Chem. 274 26584-90 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Chen, X et al. (1996) A transcriptional partner for MAD proteins in TGF-beta signalling. Nature 383 691-6 PubMed GONUTS page
↑ ^9.0 ^9.1 Inman, GJ & Hill, CS (2002) Stoichiometry of active smad-transcription factor complexes on DNA. J. Biol. Chem. 277 51008-16 PubMed GONUTS page
↑ Watanabe, M & Whitman, M (1999) FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo. Development 126 5621-34 PubMed GONUTS page

[PMID:14729957-1] 1.0 ^1.1 ^1.2 ^1.3 Randall, RA et al. (2004) Recognition of phosphorylated-Smad2-containing complexes by a novel Smad interaction motif. Mol. Cell. Biol. 24 1106-21 PubMed GONUTS page

[PMID:10691736-2] Germain, S et al. (2000) Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev. 14 435-51 PubMed GONUTS page

[PMID:12050132-3] 3.0 ^3.1 ^3.2 Howell, M et al. (2002) A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements. Development 129 2823-34 PubMed GONUTS page

[PMID:9288972-4] 4.0 ^4.1 ^4.2 Chen, X et al. (1997) Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389 85-9 PubMed GONUTS page

[PMID:10349617-5] 5.0 ^5.1 ^5.2 ^5.3 Weisberg, E et al. (1998) A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Mech. Dev. 79 17-27 PubMed GONUTS page

[PMID:11937490-6] 6.0 ^6.1 ^6.2 ^6.3 Ring, C et al. (2002) The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling. Genes Dev. 16 820-35 PubMed GONUTS page

[PMID:10473623-7] 7.0 ^7.1 ^7.2 Yeo, CY et al. (1999) The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis. J. Biol. Chem. 274 26584-90 PubMed GONUTS page

[PMID:8878477-8] 8.0 ^8.1 ^8.2 Chen, X et al. (1996) A transcriptional partner for MAD proteins in TGF-beta signalling. Nature 383 691-6 PubMed GONUTS page

[PMID:12374795-9] 9.0 ^9.1 Inman, GJ & Hill, CS (2002) Stoichiometry of active smad-transcription factor complexes on DNA. J. Biol. Chem. 277 51008-16 PubMed GONUTS page

[PMID:10572039-10] Watanabe, M & Whitman, M (1999) FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo. Development 126 5621-34 PubMed GONUTS page

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XENLA:FOXH1

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