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PMID:8878477

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Citation

Chen, X, Rubock, MJ and Whitman, M (1996) A transcriptional partner for MAD proteins in TGF-beta signalling. Nature 383:691-6

Abstract

The transforming-growth-factor-beta (TGF-beta) superfamily is critical for establishing mesoderm during early embryogenesis in Xenopus. The transcriptional activation of Mix.2, an immediate-early response gene specific to activin-like members of the TGF-beta superfamily, is associated with the rapid appearance of a site-specific DNA-binding activity that recognizes a fifty-base-pair regulatory element known as ARE in the Mix.2 promoter. Cloning of the site-specific DNA-binding component of this activity revealed it to be a new winged-helix transcription factor and a direct target for signalling by the TGF-beta superfamily. XMAD2, a recently identified TGF-beta signal transducer, forms a complex with the transcription factor in an activin-dependent fashion to generate an activated ARE-binding complex. A model is proposed to explain how TGF-beta superfamily signals might regulate the expression of specific genes in the early embryo.

Links

PubMed Online version:10.1038/383691a0

Keywords

Activins; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins/metabolism; Cloning, Molecular; DNA/metabolism; DNA-Binding Proteins/metabolism; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Inhibins/metabolism; Molecular Sequence Data; Signal Transduction; Transcription Factors/metabolism; Transcription, Genetic; Transforming Growth Factor beta/metabolism; Turner Syndrome; Xenopus; Xenopus Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

XENLA:FOXH1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

XENLA:Q91912

part_of

GO:0005667: transcription regulator complex

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P70056

C

Seeded From UniProt

complete

XENLA:FOXH1

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

XENLA:FOXH1

part_of

GO:0032444: activin responsive factor complex

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q91912

C

Seeded From UniProt

complete

XENLA:FOXH1

enables

GO:0043565: sequence-specific DNA binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

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