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WNV:POLG
Contents
| Species (Taxon ID) | West Nile virus (WNV). (11082) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Genome polyprotein
Peptide 2k Capsid protein C Core protein prM Peptide pr Small envelope protein M Matrix protein Envelope protein E Non-structural protein 1 NS1 Non-structural protein 2A NS2A Serine protease subunit NS2B Flavivirin protease NS2B regulatory subunit Non-structural protein 2B Serine protease NS3 Flavivirin protease NS3 catalytic subunit Non-structural protein 3 Non-structural protein 4A NS4A Non-structural protein 4B NS4B RNA-directed RNA polymerase NS5 NS5 | |
| External Links | ||
| UniProt | P06935 | |
| EMBL | M12294 | |
| PIR | A25256 | |
| RefSeq | NP_041724.2 | |
| PDB | 2FP7 2G05 2G2G 2GGV 2IJO 2P5P 2YOL 3E90 3I50 | |
| PDBsum | 2FP7 2G05 2G2G 2GGV 2IJO 2P5P 2YOL 3E90 3I50 | |
| DisProt | DP00673 | |
| ProteinModelPortal | P06935 | |
| SMR | P06935 | |
| IntAct | P06935 | |
| BindingDB | P06935 | |
| ChEMBL | CHEMBL5419 | |
| GeneID | 912267 | |
| EvolutionaryTrace | P06935 | |
| PRO | PR:P06935 | |
| Proteomes | UP000008600 | |
| GO | GO:0044167 GO:0042025 GO:0016021 GO:0019028 GO:0019031 GO:0055036 GO:0005524 GO:0008026 GO:0003725 GO:0046872 GO:0004482 GO:0004483 GO:0008233 GO:0003724 GO:0003968 GO:0004252 GO:0070008 GO:0005198 GO:0075512 GO:0039654 GO:0039520 GO:0045070 GO:0006355 GO:0019050 GO:0039576 GO:0039574 GO:0039502 GO:0006351 GO:0039694 GO:0019062 | |
| Gene3D | 2.60.40.350 2.60.98.10 3.30.387.10 3.40.50.150 3.40.50.300 | |
| InterPro | IPR011492 IPR000069 IPR013755 IPR001122 IPR026470 IPR001157 IPR000752 IPR000487 IPR000404 IPR001528 IPR002535 IPR000336 IPR001850 IPR027287 IPR014412 IPR011998 IPR013754 IPR014001 IPR001650 IPR014756 IPR026490 IPR027417 IPR000208 IPR007094 IPR002877 IPR029063 IPR009003 | |
| Pfam | PF01003 PF07652 PF02832 PF00869 PF01004 PF00948 PF01005 PF01002 PF01350 PF01349 PF00972 PF01570 PF01728 PF00271 PF00949 | |
| PIRSF | PIRSF003817 | |
| SMART | SM00487 SM00490 | |
| SUPFAM | SSF50494 SSF52540 SSF53335 SSF56983 SSF81296 | |
| TIGRFAMs | TIGR04240 | |
| PROSITE | PS51527 PS51528 PS51192 PS51194 PS50507 PS51591 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0019050 |
suppression by virus of host apoptotic process |
ECO:0000314 |
P |
As is the case with many RNA viruses, infection of mammalian cells with West Nile Virus has been reported to cause apoptosis. Replication of WNV and other flaviviruses is relatively slow, and therefore, it is not seemingly beneficial to the virus if the first viral protein produced in an infected cell induces programmed cell death. In contrast, during the early stages of flavivirus infection, apoptosis appears to be inhibited by a process that involves activation of the prosurvival kinase Akt. Recent studies revealed that antiapoptotic/survival signaling is activated shortly after flavivirus infection. This signaling process involves the kinase Akt, which is activated by PI3K-dependent phosphorylation on serine 473. As seen in figure 7, inhibition of PI3 kinase abrogates protection by WNV capsid protein. This was done when A549 cells were transduced with lentiviruses encoding WNV capsid protein or AcGFP alone, before challenge with anti-Fas with or without addition of LY294002. |
complete | |||||
| GO:0045070 |
positive regulation of viral genome replication |
ECO:0000315 |
P |
Figure 3 and figure 4 for NS4B, but the expt was done in the presence of NS4 F86C mutation, but UniProt doesn't offer separate mature protein record for each component of the polyprotein from WNV. |
complete | |||||
| GO:0008233 |
peptidase activity |
ECO:0000314 |
F |
As seen in Figure 1, WNV protease retained activity in most of the detergents tested in this study. WNV protease possesses catalytic activity in the presence of some detergents, making it useful for the removal of an affinity tag in a membrane protein preparation. It is suggested that WNV protease can be used for the preparation of a membrane protein or a transmembrane domain segment from a multi-span transmembrane protein. |
complete | |||||
|
enables |
GO:0033592 |
RNA strand annealing activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043489 |
RNA stabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0106005 |
RNA 5'-cap (guanine-N7)-methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004483 |
mRNA (nucleoside-2'-O-)-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045070 |
positive regulation of viral genome replication |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019050 |
suppression by virus of host apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:1990814 |
DNA/DNA annealing activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1990904 |
ribonucleoprotein complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080009 |
mRNA methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080009 |
mRNA methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080009 |
mRNA methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004483 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003724 |
RNA helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003725 |
double-stranded RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004482 |
mRNA (guanine-N7-)-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004483 |
mRNA (nucleoside-2'-O-)-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008026 |
ATP-dependent helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016070 |
RNA metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016817 |
hydrolase activity, acting on acid anhydrides |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019031 |
viral envelope |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019058 |
viral life cycle |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039694 |
viral RNA genome replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004483 |
mRNA (nucleoside-2'-O-)-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004482 |
mRNA (guanine-N7-)-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075512 |
clathrin-dependent endocytosis of virus by host cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0039714 |
cytoplasmic viral factory |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019031 |
viral envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044165 |
host cell endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039576 |
suppression by virus of host JAK1 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039663 |
membrane fusion involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039564 |
suppression by virus of host STAT2 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006370 |
7-methylguanosine mRNA capping |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039654 |
fusion of virus membrane with host endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039563 |
suppression by virus of host STAT1 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075509 |
endocytosis involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075512 |
clathrin-dependent endocytosis of virus by host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019062 |
virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039520 |
induction by virus of host autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039574 |
suppression by virus of host TYK2 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044220 |
host cell perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044167 |
host cell endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055036 |
virion membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Urbanowski, MD & Hobman, TC (2013) The West Nile virus capsid protein blocks apoptosis through a phosphatidylinositol 3-kinase-dependent mechanism. J. Virol. 87 872-81 PubMed GONUTS page
- ↑ 2.0 2.1 Youn, S et al. (2012) Evidence for a genetic and physical interaction between nonstructural proteins NS1 and NS4B that modulates replication of West Nile virus. J. Virol. 86 7360-71 PubMed GONUTS page
- ↑ 3.0 3.1 Huang, Q et al. (2013) West Nile virus protease activity in detergent solutions and application for affinity tag removal. Anal. Biochem. 435 44-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Ivanyi-Nagy, R et al. (2008) RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae. Nucleic Acids Res. 36 712-25 PubMed GONUTS page
- ↑ 5.0 5.1 Zhou, Y et al. (2007) Structure and function of flavivirus NS5 methyltransferase. J. Virol. 81 3891-903 PubMed GONUTS page
- ↑ Chu, JJ & Ng, ML (2004) Infectious entry of West Nile virus occurs through a clathrin-mediated endocytic pathway. J. Virol. 78 10543-55 PubMed GONUTS page
- ↑ Kaufusi, PH et al. (2014) Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B. PLoS ONE 9 e84040 PubMed GONUTS page
c
d
h
- GO:0004386 ! helicase activity
- GO:0030430 ! host cell cytoplasm
- GO:0044167 ! host cell endoplasmic reticulum membrane
- GO:0044165 ! host cell endoplasmic reticulum
- GO:0033644 ! host cell membrane
- GO:0042025 ! host cell nucleus
- GO:0044220 ! host cell perinuclear region of cytoplasm
- GO:0016817 ! hydrolase activity, acting on acid anhydrides
- GO:0016787 ! hydrolase activity
m
- GO:0016020 ! membrane
- GO:0039663 ! membrane fusion involved in viral entry into host cell
- GO:0008152 ! metabolic process
- GO:0046872 ! metal ion binding
- GO:0032259 ! methylation
- GO:0008168 ! methyltransferase activity
- GO:0030683 ! mitigation of host immune response by virus
- GO:0004483 ! mRNA (nucleoside-2'-O-)-methyltransferase activity
- GO:0004482 ! mRNA 5'-cap (guanine-N7-)-methyltransferase activity
- GO:0006397 ! mRNA processing
o
p
r
- GO:1990904 ! ribonucleoprotein complex
- GO:0017111 ! ribonucleoside triphosphate phosphatase activity
- GO:0003968 ! RNA-dependent RNA polymerase activity
- GO:0001172 ! RNA-templated transcription
- GO:0106005 ! RNA 5'-cap (guanine-N7)-methylation
- GO:0003723 ! RNA binding
- GO:0003724 ! RNA helicase activity
- GO:0016070 ! RNA metabolic process
- GO:0043489 ! RNA stabilization
- GO:0033592 ! RNA strand annealing activity
s
- GO:0004252 ! serine-type endopeptidase activity
- GO:0008236 ! serine-type peptidase activity
- ssRNA positive-strand viruses, no DNA stage
- GO:0005198 ! structural molecule activity
- GO:0039564 ! symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
- GO:0039576 ! symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity
- GO:0039563 ! symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
- GO:0039502 ! symbiont-mediated suppression of host type I interferon-mediated signaling pathway
- GO:0039520 ! symbiont-mediated activation of host autophagy
- GO:0039574 ! symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity
- GO:0046718 ! symbiont entry into host cell
v
