User:SMass

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	MOUSE:MUTYH	2017-04-06 14:24:00 CDT	GO:0060546 negative regulation of necroptotic process (P)	PMID:28059467	ECO:0000315 mutant phenotype evidence used in manual assertion	In figure 2A, loss of MYH results in more TNF-alpha combined with zVAD-fmk induced cell death in primary mouse embryonic fibroblasts (MEFs).	challenge
unacceptable	HUMAN:APEX1	2017-04-23 12:29:28 CDT	GO:0003697 single-stranded DNA binding (F)	PMID:26773055	ECO:0000314 direct assay evidence used in manual assertion	in Figure 3A, histogram displaying a ChIP analysis assessing Sp1 binding to APEX1 proximal promoter. The assay was carried out using TIG-1 cells transfected with either a control siRNA, a XRCC1 siRNA or a Sp1-targeting siRNA (as positive control for signal reduction). Results are expressed as mean fold enrichment over unspecific IgG relative to control siRNA ± SD of three independent experiments.	challenge
unacceptable	MOUSE:NEO1	2017-04-23 13:38:04 CDT	GO:0006779 porphyrin-containing compound biosynthetic process (P)	PMID:28431013	ECO:0000315 mutant phenotype evidence used in manual assertion	figure 7B, Table showing in vitro recombination catalysed by hepatopancreas extract and its heat inactivated form. Mouse testicular extracts acted as a positive control.	challenge
unacceptable	MOUSE:STIL	2017-04-23 15:20:17 CDT	GO:0072718 response to cisplatin (P)	PMID:28423708	ECO:0000315 mutant phenotype evidence used in manual assertion	in figure 2(D-F), knockdown of STIL gene significantly enhanced the sensitivity to cisplatin cure	challenge

acceptable:0
unacceptable:3
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Annotations challenged by SMass

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

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