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MOUSE:STIL

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Stil (synonyms: Sil)
Protein Name(s) SCL-interrupting locus protein homolog
External Links
UniProt Q60988
EMBL U36778
AJ297131
AK019471
AK049223
BC004585
BC049865
CCDS CCDS18485.1
RefSeq NP_033211.2
UniGene Mm.3988
ProteinModelPortal Q60988
SMR Q60988
STRING 10090.ENSMUSP00000030490
iPTMnet Q60988
PhosphoSitePlus Q60988
EPD Q60988
PaxDb Q60988
PRIDE Q60988
GeneID 20460
KEGG mmu:20460
CTD 6491
MGI MGI:107477
eggNOG ENOG410IF1P
ENOG4111HAF
HOGENOM HOG000231284
HOVERGEN HBG079548
InParanoid Q60988
KO K16724
PhylomeDB Q60988
PRO PR:Q60988
Proteomes UP000000589
CleanEx MM_STIL
GO GO:0005814
GO:0005813
GO:0005737
GO:0005829
GO:0051298
GO:0007368
GO:0000578
GO:0033504
GO:0030900
GO:0001947
GO:0001701
GO:0007052
GO:0035264
GO:0043066
GO:0001843
GO:0021915
GO:1905515
GO:0030903
GO:0045737
GO:0071539
GO:0046599
GO:0007224
InterPro IPR026123
PANTHER PTHR15128:SF1
Pfam PF15253

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006303

double-strand break repair via nonhomologous end joining

28423708:28423708

ECO:0000314

P

Description: Figure 6A and B. AD51-dependent HRR had changed much in the presence of STIL (by increasing). NHEJ hadn’t changed much in the presence of STIL.

complete
CACAO 12778

GO:0072718

response to cisplatin

PMID:28423708[1]

ECO:0000315

P

in figure 2(D-F), knockdown of STIL gene significantly enhanced the sensitivity to cisplatin cure

complete
CACAO 12830

part_of

GO:0005814

centriole

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15468

C

Seeded From UniProt

complete

involved_in

GO:0046599

regulation of centriole replication

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15468

P

Seeded From UniProt

complete

involved_in

GO:0071539

protein localization to centrosome

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001031679
UniProtKB:Q15468

P

Seeded From UniProt

complete

involved_in

GO:0051298

centrosome duplication

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107477
PANTHER:PTN001031679
UniProtKB:Q15468

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107477
PANTHER:PTN001031679
ZFIN:ZDB-GENE-020419-39

P

Seeded From UniProt

complete

involved_in

GO:0007052

mitotic spindle organization

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001031679
UniProtKB:Q15468

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001031679
UniProtKB:Q15468

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001031679
UniProtKB:Q15468

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905515

non-motile cilium assembly

PMID:22349705[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071539

protein localization to centrosome

PMID:22349705[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051298

centrosome duplication

PMID:22349705[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051298

centrosome duplication

PMID:22349705[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046599

regulation of centriole replication

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:16024801[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

regulates_o_occurs_in:(EMAPA:16039)

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035264

multicellular organism growth

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033504

floor plate development

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030903

notochord development

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

results_in_development_of:(EMAPA:16191)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030900

forebrain development

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

results_in_development_of:(EMAPA:16144)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021915

neural tube development

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

results_in_development_of:(EMAPA:16164)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007368

determination of left/right symmetry

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007224

smoothened signaling pathway

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

occurs_in:(EMAPA:16039)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007052

mitotic spindle organization

PMID:22349705[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:22349705[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:22349705[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22349705[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15468

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001947

heart looping

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001843

neural tube closure

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

has_participant:(EMAPA:16164)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001701

in utero embryonic development

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000578

embryonic axis specification

PMID:10385121[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2152962

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Rabinowicz, N et al. (2017) Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer. Oncotarget 27380-27392 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Vulprecht, J et al. (2012) STIL is required for centriole duplication in human cells. J. Cell. Sci. 125 1353-62 PubMed GONUTS page
  4. ↑ Campaner, S et al. (2005) Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint. Mol. Cell. Biol. 25 6660-72 PubMed GONUTS page
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 Izraeli, S et al. (1999) The SIL gene is required for mouse embryonic axial development and left-right specification. Nature 399 691-4 PubMed GONUTS page
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