MOUSE:MUTYH

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mutyh (synonyms: Myh)
Protein Name(s)	Adenine DNA glycosylase MutY homolog mMYH
External Links
UniProt	Q99P21
EMBL	AY007717 AB117938 AL683847 BC057942
CCDS	CCDS18518.1
RefSeq	NP_001153053.1 NP_573513.2
UniGene	Mm.180333
ProteinModelPortal	Q99P21
SMR	Q99P21
BioGrid	214159
STRING	10090.ENSMUSP00000099760
PhosphoSitePlus	Q99P21
EPD	Q99P21
PaxDb	Q99P21
PRIDE	Q99P21
Ensembl	ENSMUST00000102699
GeneID	70603
KEGG	mmu:70603
UCSC	uc008uhm.2
CTD	4595
MGI	MGI:1917853
eggNOG	KOG2457 COG1194
GeneTree	ENSGT00510000047220
HOGENOM	HOG000028743
HOVERGEN	HBG052540
InParanoid	Q99P21
KO	K03575
OMA	LCRARQR
OrthoDB	EOG091G04AB
TreeFam	TF328549
Reactome	[www.reactome.org/content/detail/R-MMU-110331 R-MMU-110331] [www.reactome.org/content/detail/R-MMU-110357 R-MMU-110357]
PRO	PR:Q99P21
Proteomes	UP000000589
Bgee	ENSMUSG00000028687
CleanEx	MM_MUTYH
ExpressionAtlas	Q99P21
Genevisible	Q99P21
GO	GO:0005739 GO:0005634 GO:0051539 GO:0003677 GO:0019104 GO:0046872 GO:0032407 GO:0006284 GO:0006281
CDD	cd03431 cd00056
Gene3D	1.10.1670.10 1.10.340.30 3.90.79.10
InterPro	IPR011257 IPR004036 IPR004035 IPR003651 IPR003265 IPR000445 IPR023170 IPR029119 IPR000086 IPR015797
Pfam	PF10576 PF00633 PF00730 PF14815
SMART	SM00478 SM00525
SUPFAM	SSF48150 SSF55811
PROSITE	PS00764 PS01155 PS51462

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0060546	negative regulation of necroptotic process	PMID:28059467^[1]	ECO:0000315			P	In figure 2A, loss of MYH results in more TNF-alpha combined with zVAD-fmk induced cell death in primary mouse embryonic fibroblasts (MEFs).	complete CACAO 12471
enables	GO:0000701	purine-specific mismatch base pair DNA N-glycosylase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UIF7	F	Seeded From UniProt	complete
enables	GO:0035485	adenine/guanine mispair binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000040628 PomBase:SPAC26A3.02	F	Seeded From UniProt	complete
enables	GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000040628 PomBase:SPAC26A3.02	F	Seeded From UniProt	complete
enables	GO:0032357	oxidized purine DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000040628 PomBase:SPAC26A3.02	F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000040628 PomBase:SPAC26A3.02	P	Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10627 PANTHER:PTN000040628	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000040628 UniProtKB:Q9HU37	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000040629 PomBase:SPAC26A3.02 RGD:620045 UniProtKB:Q9UIF7	C	Seeded From UniProt	complete
enables	GO:0000701	purine-specific mismatch base pair DNA N-glycosylase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000040628 PomBase:SPAC26A3.02 UniProtKB:Q9UIF7	F	Seeded From UniProt	complete
enables	GO:0032407	MutSalpha complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UIF7	F	Seeded From UniProt	complete
enables	GO:0019104	DNA N-glycosylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620045	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620045	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620045	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UIF7	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620045	C	Seeded From UniProt	complete
enables	GO:0000701	purine-specific mismatch base pair DNA N-glycosylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UIF7	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E5KP26 ensembl:ENSP00000361170	C	Seeded From UniProt	complete
enables	GO:0032407	MutSalpha complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UIF7 ensembl:ENSP00000361170	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UIF7 ensembl:ENSP00000361170	C	Seeded From UniProt	complete
enables	GO:0000701	purine-specific mismatch base pair DNA N-glycosylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UIF7 ensembl:ENSP00000361170	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000445	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011257	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011257	P	Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003265	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000086 InterPro:IPR015797	F	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003651	F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9606338	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019104	DNA N-glycosylase activity	PMID:12200441^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	PMID:12200441^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0051536	iron-sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0411	F	Seeded From UniProt	complete
enables	GO:0051539	4 iron, 4 sulfur cluster binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0004	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tran, AH et al. (2017) MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis. J. Cell. Biochem. PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ ^4.0 ^4.1 Takao, M et al. (2002) A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. J. Biol. Chem. 277 42205-13 PubMed GONUTS page

[PMID:28059467-1] Tran, AH et al. (2017) MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis. J. Cell. Biochem. PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18614015-3] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:12200441-4] 4.0 ^4.1 Takao, M et al. (2002) A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. J. Biol. Chem. 277 42205-13 PubMed GONUTS page

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MOUSE:MUTYH

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