User:RPatel

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	ENTFA:Q837U3	2018-03-18 20:10:42 CDT	GO:0070051 fibrinogen binding (F)	PMID:29487730	ECO:0000021 physical interaction evidence	The paper focused on gene EF0737 from Enterococcus faecalis .The authors evaluated interaction of recombinant EF0737 protein with fibrinogen proteins using a western blot (Fig. 6).	challenge
acceptable	I34A1:PA	2018-04-22 08:28:29 CDT	GO:0004519 endonuclease activity (F)	PMID:16873236	ECO:0000315 mutant phenotype evidence used in manual assertion	The experiment focused on the precise role of PA subunit of RNA-dependent RNA Polymerase in transcription. Previous research has suggested that mutant H510A in PA subunit has impaired endonuclease activity and selective inhibited transcription. They used three mutant phenotypes of PA subunit: K102A, D108A, and K134A to determine the effect on polymerase activity. No significant endonuclease activity was determined for mutations which indicates that PA is involved in endonuclease activity (Fig. 5D and G).	challenge
acceptable	PBCV1:KCV	2018-04-22 16:35:53 CDT	GO:0006813 potassium ion transport (P)	PMID:18045641	ECO:0000314 direct assay evidence used in manual assertion	During early infection, Chorella evoke an increase in [K+]. The mechanism for this efflux was hypothesized to be Kcv proteins.As the author used a Kcv blockers like Ba2+ and Cs+ and the usage of them resulted in decrease in potassium efflux (Fig. 5). The Ba2+ inhibition of virus-triggered K+ efflux is also reflected in a reduced release of K+ from the cells (Fig. 5B). Thus Kcv is involved in the potassium ion transport.	challenge

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