I34A1:PA

Species (Taxon ID)	Influenza A virus (strain A/Puerto Rico/8/1934 H1N1). (211044)
Gene Name(s)	PA (ECO:0000255 with HAMAP-Rule:MF_04063)
Protein Name(s)	Polymerase acidic protein (ECO:0000255 with HAMAP-Rule:MF_04063) RNA-directed RNA polymerase subunit P2 (ECO:0000255 with HAMAP-Rule:MF_04063)
External Links
UniProt	P03433
EMBL	V01106 AF389117 EF467820 CY009449
RefSeq	NP_040986.1
PDB	2ZNL 4YYL 4ZHZ 4ZI0 4ZQQ 5FDD 5FDG 5I13 5JHT 5JHV
PDBsum	2ZNL 4YYL 4ZHZ 4ZI0 4ZQQ 5FDD 5FDG 5I13 5JHT 5JHV
ProteinModelPortal	P03433
SMR	P03433
DIP	DIP-43996N
IntAct	P03433
MINT	P03433
BindingDB	P03433
ChEMBL	CHEMBL1169598
GeneID	956535
KEGG	vg:956535
KO	K19390
OrthoDB	VOG0900002P
BRENDA	2.7.7.48
Reactome	R-HSA-168255 R-HSA-168271 R-HSA-168275 R-HSA-168288 R-HSA-168298 R-HSA-168302 R-HSA-168303 R-HSA-168325 R-HSA-168330 R-HSA-168333 R-HSA-168336 R-HSA-192814 R-HSA-192823 R-HSA-192869 R-HSA-192905
EvolutionaryTrace	P03433
Proteomes	UP000009255 UP000116373 UP000170967
GO	GO:0005829 GO:0031904 GO:0005576 GO:0030430 GO:0042025 GO:0005654 GO:0004519 GO:0046872 GO:0003723 GO:0075526 GO:0019064 GO:0075733 GO:0019065 GO:0039523 GO:0019061 GO:0046761 GO:0019070 GO:0019072 GO:0019076 GO:0039694 GO:0019083 GO:0019062
Gene3D	3.40.91.90
HAMAP	MF_04063
InterPro	IPR037534 IPR001009 IPR038372
Pfam	PF00603

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0004519	endonuclease activity	PMID:16873236	ECO:0000315			F		The experiment focused on the precise role of PA subunit of RNA-dependent RNA Polymerase in transcription. Previous research has suggested that mutant H510A in PA subunit has impaired endonuclease activity and selective inhibited transcription. They used three mutant phenotypes of PA subunit: K102A, D108A, and K134A to determine the effect on polymerase activity. No significant endonuclease activity was determined for mutations which indicates that PA is involved in endonuclease activity (Fig. 5D and G).	complete CACAO 13286
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001009 InterPro:IPR037534	F		Seeded From UniProt	complete
involved_in	GO:0039694	viral RNA genome replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001009 InterPro:IPR037534	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523862	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523862	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523862	C		Seeded From UniProt	complete
involved_in	GO:0039523	suppression by virus of host RNA polymerase II activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523862	P		Seeded From UniProt	complete
involved_in	GO:0075526	cap snatching	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523862	P		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000523862	C		Seeded From UniProt	complete
involved_in	GO:0075733	intracellular transport of virus	Reactome:R-HSA-168893 Reactome:R-HSA-168880 Reactome:R-HSA-168857 Reactome:R-HSA-168337 Reactome:R-HSA-168317 Reactome:R-HSA-168310 Reactome:R-HSA-168297	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046761	viral budding from plasma membrane	Reactome:R-HSA-168860	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031904	endosome lumen	Reactome:R-HSA-168324 Reactome:R-HSA-168313 Reactome:R-HSA-168312 Reactome:R-HSA-168306 Reactome:R-HSA-168299 Reactome:R-HSA-168285	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019083	viral transcription	Reactome:R-HSA-168334 Reactome:R-HSA-168326 Reactome:R-HSA-168301 Reactome:R-HSA-168280 Reactome:R-HSA-168273	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019072	viral genome packaging	Reactome:R-HSA-168895 Reactome:R-HSA-168303	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019070	viral genome maturation	Reactome:R-HSA-168330	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019065	receptor-mediated endocytosis of virus by host cell	Reactome:R-HSA-168285	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019064	fusion of virus membrane with host plasma membrane	Reactome:R-HSA-168312 Reactome:R-HSA-168306 Reactome:R-HSA-168288	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019062	virion attachment to host cell	Reactome:R-HSA-168272	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019061	uncoating of virus	Reactome:R-HSA-168313 Reactome:R-HSA-168299	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-195926 Reactome:R-HSA-192841 Reactome:R-HSA-168895 Reactome:R-HSA-168880 Reactome:R-HSA-168860 Reactome:R-HSA-168337 Reactome:R-HSA-168317 Reactome:R-HSA-168299 Reactome:R-HSA-168297	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-192916 Reactome:R-HSA-192851 Reactome:R-HSA-192832 Reactome:R-HSA-192830 Reactome:R-HSA-192746 Reactome:R-HSA-192677 Reactome:R-HSA-192624 Reactome:R-HSA-168893 Reactome:R-HSA-168880 Reactome:R-HSA-168857 Reactome:R-HSA-168337 Reactome:R-HSA-168334 Reactome:R-HSA-168326 Reactome:R-HSA-168310 Reactome:R-HSA-168301 Reactome:R-HSA-168280	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-168870 Reactome:R-HSA-168860 Reactome:R-HSA-168285 Reactome:R-HSA-168272	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C		Seeded From UniProt	complete
involved_in	GO:0039523	suppression by virus of host RNA polymerase II activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1104	P		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C		Seeded From UniProt	complete
involved_in	GO:0075526	cap snatching	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1157	P		Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1190	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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References

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