User:ORichter

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	LAMBD:SPAN2	2018-03-04 19:10:43 CST	GO:0019076 cytolysis (P)	PMID:28040784	ECO:0000314 direct assay evidence used in manual assertion	Only the C-terminal R153 residue is dispensable; there are lysis-defective nonsense mutations at positions 151 and 152 shown (Table 3) in the CTD region. A nonsense mutation (Rz C152X) shows the same effect as lysogen carrying an empty pRE plasmid vector (Vector), inhibiting cytolysis (Figure 3). The wild type pRz (WT), pRz with an artificial transmembrane domain (ART-TMD), and pRz 100–115 (Ser-Gly) show effective cytolysis in Figure 3.	challenge
acceptable	STRCL:BLIP	2018-04-15 20:27:30 CDT	GO:0033252 regulation of beta-lactamase activity (P)	PMID:21238457	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3 shows the interaction between K74G BLIP (a beta-lactamase inhibitory protein mutant) with S. aureus PC1 wild-type β-lactamase and its A104E (beta-lactamase) mutant. K74G BLIP has greater inhibitory effect on the wild type beta-lactamase than the mutant beta-lactamase. Table 2 includes the inhibition constant of the purified K74G BLIP variant for PC1 β-lactamase, which shows about a 10-fold increase in comparison to that of wild type BLIP.	challenge

acceptable:2
unacceptable:0
requires_changes:0
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Annotations challenged by ORichter

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
acceptable	HPaudel, Team Green B 2018	BPT5:TMP	GO:0061783 - peptidoglycan muralytic activity (F)	PMID:18348984	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3

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