User:Aaron.Bedford

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	CHIKS:POLN	2014-02-28 14:33:23 CST	GO:0044188 host cell lysosomal membrane (C)	PMID:19180189	ECO:0000315 mutant phenotype evidence used in manual assertion	Non structural protein (NSP) 1 as a IFN antagonist. See figure 1	challenge
unacceptable	HPV16:VE2	2014-02-28 14:43:20 CST	GO:0075512 clathrin-mediated endocytosis of virus by host cell (P)	PMID:1370493	ECO:0000315 mutant phenotype evidence used in manual assertion	"E1 fusion protein uses first heterodimerization with p62 as a means to become incorporated into the viral envelope and then dissociation from the cleaved p62 (e2), and reorganization, possibly within itself as a way to become activated (Membrane Fusion Process, pg.9)." See Table 1 of Papaer	challenge
acceptable	SINDV:POLS	2014-03-20 16:07:39 CDT	GO:0019062 virion attachment to host cell (P)	PMID:7684466	ECO:0000315 mutant phenotype evidence used in manual assertion	Mutant strains of sindbis virus with insertion sequences in the PE2 glycoprotein gene have significantly reduced binding capabilities. PE2 cleavage is necessary for E2/E3 specific spike protein with E2 specific for receptor binding. See Fig. 3; Fig. 6; Fig. 7; Fig. 8	challenge
updatedbyinstructor	SINDV:POLN	2014-03-22 19:15:01 CDT	GO:0008174 mRNA methyltransferase activity (F)	PMID:8610444	ECO:0000315 mutant phenotype evidence used in manual assertion	Table 1 represents the results of the mutations on various clones to express MTase activity. Changes and/or deletions to conserved amino acid sequences in nsP1 resulted in lower Km for S-adenosyl methionine. Reduced methyl donor substrate concentration significantly reduced MTase activity and viral infectivity.	challenge

acceptable:1
unacceptable:2
requires_changes:0
flagged:0

Annotations challenged by Aaron.Bedford

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Aaron.Bedford, Team Just Name It Something	SINDV:POLN	GO:0008174 - mRNA methyltransferase activity (F)	PMID:8610444	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 2 fixed by Aaron.Bedford

1 annotations fixed by Aaron.Bedford

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