GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| GO:0045870 | positive regulation of retroviral genome replication | PMID:22593154 | IDA: Inferred from Direct Assay | P | ||||
| This annotation made on page: HV1BR:TAT By: Jbeasley (group Team Everything Burrito) on 2013-02-10 13:06:18 CST. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Deradeza, Team Team TATAboxxx | 2013-04-17 20:59:13 CDT | The Go term talks about positive regulation of retroviral genome replication, but the argument is that this protein increases gene expression or transcription of a specific sequence/virus. So the GO term should not include replication. Instead, the GO term should be GO:0045815 "Positive Regulation of Gene Expression, Epigenetics". Since the tat protein is a viral protein, it seemed more correct to select this one instead of just "Positive regulation of gene expression" | 0 |
| Challenge | Fisch183, Team The Knockouts | 2013-04-07 17:36:24 CDT | I believe that the GO term is incorrect. This paper is showing the activation of HIV-1 by the Tat protein found in HML-2. Figure 4 shows how HIV-1 Tat activates HML-2 promoter by a different mechanism than used to activate HIV-1. So they are looking at how the Tat protein is binding through a viral transactivating regulatory protein. The correct GO term should be GO:0030957 | 0 |
| Challenge | Kpatel, Team Llamarmy | 2013-02-17 13:42:57 CST | I believe the Go Term used is too specific as from figure A we can also see a decrease starting at the 12 hour mark and continuing with time. The Go term should be replaced with GO:0045090. | 0 |
| Private Assessment | Bmcintosh | 2013-06-21 21:56:21 CDT | You need to be an instructor to view these notes. | Updated by Instructor ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Private Assessment | JimHu | 2013-04-26 12:17:37 CDT | You need to be an instructor to view these notes. | Requires Changes ✔ Go term |
| Public Assessment | DanielRenfro | 2013-04-17 20:59:14 CDT | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | Suzialeksander | 2013-04-09 13:32:26 CDT | You need to be an instructor to view these notes. | Requires Changes ✗ Go term |
| Public Assessment | DanielRenfro | 2013-04-07 17:36:24 CDT | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | Suzialeksander | 2013-02-20 12:58:06 CST | You need to be an instructor to view these notes. | Requires Changes ✗ Go term |
| Public Assessment | DanielRenfro | 2013-02-17 13:42:57 CST | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | Bmcintosh | 2013-02-15 12:46:06 CST | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
