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GO:0052657guanine phosphoribosyltransferase activityother:http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2007.05970.x/fullIDA: Inferred from Direct Assay F
This annotation made on page: HUMAN:HPRT
By: Barlowrm (group Team TRUMP2016) on 2016-04-11 11:22:55 CDT.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeDelgalej,
Team Smudgehunters
2016-04-13 14:53:09 CDT

The paper referenced isn't about Hakuna at all. Also you should use a PMID instead of just a link.

1
ChallengeKaycee.Bartels,
Team Tiger1
2016-04-12 13:54:44 CDT

For your reference you need to have a PMID as opposed to a link. The correct PMID is 17662107.

2
Private
Assessment
Suzialeksander2016-06-27 16:06:44 CDTYou need to be an instructor to view these notes.Unacceptable
Public
Assessment
AAJohnson2016-05-16 07:35:13 CDT

This is an annotation of Human HPRT1. The paper describes HPRT1 from Thermoanaerobacter tengcongensis, a different organism. If you want to use this paper, you need to create a gene page for the correct protein from the correct organism. You need a GO term reflecting the activity of that protein, not the SEA PHAGES GO_REF. You'll probably use IMP, as this paper describes the activity and structure of HPRT1 with several different point mutations.

Requires Changes
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original
Public
Assessment
DanielRenfro2016-05-04 16:06:39 CDT

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000100 S-methylmethionine transmembrane transporter activity PMID:17662107 ISS: Inferred from Sequence Similarity UniProtKB:Q8R7L0 F The main protein ribose-phosphate pyrophosphokinase from the Hakuna Genome, shares a homology with guanine phosphoribosyltransferase with an e score of 4e-10 according to HHPRED. The function and structure of this protein is to design compounds that would be effective inhibitors. "Almost all of the inhibitors available are analogues of the substrate or transition-state. The main drawback of these compounds is that there is poor differential inhibition among various HGPRTs. The reason maybe due to high structure similarity of HGPRTs from different species (especially the active site) even though there is only moderate sequence homology. The key residues in the active site are highly similar among HGPRTs (TableĀ 1)." complete
CACAO 11622
on HUMAN:HPRT
Flagged