It is now the 3rd CHALLENGE Period for CACAO Fall 2017! It will end on Sunday October 22, 2017 at 11:59 pm CDT
This is your chance to challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

SCHPO:TSA1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) tpx1 (synonyms: tsa1)
Protein Name(s) Peroxiredoxin tpx1

Peroxiredoxin tsa1 Thioredoxin peroxidase

External Links
UniProt O74887
EMBL AF083335
CU329672
PIR T41413
RefSeq NP_588430.1
HSSP P32119
ProteinModelPortal O74887
SMR O74887
MINT MINT-4681567
STRING O74887
PeroxiBase 4483
PRIDE O74887
EnsemblFungi SPCC576.03c.1
GeneID 2539572
GenomeReviews CU329672_GR
KEGG spo:SPCC576.03c
PomBase SPCC576.03c
eggNOG COG0450
HOGENOM HOG000022343
OMA EFQDINA
OrthoDB EOG4SN4Z0
NextBio 20800731
GO GO:0005829
GO:0005634
GO:0008379
GO:0045454
GO:0042744
GO:0043433
GO:0006457
GO:0019430
Gene3D 3.40.30.10
InterPro IPR000866
IPR024706
IPR019479
IPR012336
Pfam PF10417
PF00578
PIRSF PIRSF000239
SUPFAM SSF52833
PROSITE PS51352

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004601

peroxidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0575

F

Seeded From UniProt

GO:0004601

peroxidase activity

PMID:17409354[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15824112[2]

IPI: Inferred from Physical Interaction

PomBase:SPAC24B11.06c

F

Seeded From UniProt

GO:0005515

protein binding

PMID:17409354[1]

IPI: Inferred from Physical Interaction

PomBase:SPAC7D4.07c

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16823372[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000004490

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:22245228[4]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005829

cytosol

PMID:16823372[3]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0006457

protein folding

GO_REF:0000024

ISO: Inferred from Sequence Orthology

SGD:S000004490

P

Seeded From UniProt

GO:0008379

thioredoxin peroxidase activity

PMID:15225554[5]

TAS: Traceable Author Statement

-

F

Seeded From UniProt

GO:0016209

antioxidant activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000866

F

Seeded From UniProt

GO:0016209

antioxidant activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0049

F

Seeded From UniProt

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000866

F

Seeded From UniProt

GO:0016491

oxidoreductase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

Seeded From UniProt

GO:0019430

removal of superoxide radicals

GO_REF:0000001

IC: Inferred by Curator

GO:0004602

P

Seeded From UniProt

GO:0034599

cellular response to oxidative stress

PMID:15225554[5]

IGI: Inferred from Genetic Interaction

PomBase:SPAC24B11.06c

P

Seeded From UniProt

GO:0042744

hydrogen peroxide catabolic process

GO_REF:0000001

IC: Inferred by Curator

GO:0008379

P

Seeded From UniProt

GO:0042744

hydrogen peroxide catabolic process

PMID:22245228[4]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0043433

negative regulation of sequence-specific DNA binding transcription factor activity

PMID:22245228[4]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0045454

cell redox homeostasis

PMID:17409354[1]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0051920

peroxiredoxin activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR019479

F

Seeded From UniProt

GO:0051920

peroxiredoxin activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.11.1.15

F

Seeded From UniProt

GO:0051920

peroxiredoxin activity

PMID:17409354[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000866
InterPro:IPR019479

P

Seeded From UniProt

GO:0055114

oxidation-reduction process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Jara, M et al. (2007) The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast. Mol. Biol. Cell 18 2288-95 PubMed GONUTS page
  2. Bozonet, SM et al. (2005) Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide. J. Biol. Chem. 280 23319-27 PubMed GONUTS page
  3. 3.0 3.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 Day, AM et al. (2012) Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival. Mol. Cell 45 398-408 PubMed GONUTS page
  5. 5.0 5.1 Veal, EA et al. (2004) A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase. Mol. Cell 15 129-39 PubMed GONUTS page