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SCHPO:TSA1

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) tpx1 (synonyms: tsa1)
Protein Name(s) Peroxiredoxin tpx1 (ECO:0000303 with PMID:20356456[1])

Thioredoxin peroxidase (ECO:0000303 with PMID:20356456[1]) TPx (ECO:0000303 with PMID:20356456[1])

External Links
UniProt O74887
EMBL AF083335
CU329672
PIR T41413
RefSeq NP_588430.1
ProteinModelPortal O74887
SMR O74887
BioGrid 276132
IntAct O74887
MINT O74887
STRING 4896.SPCC576.03c.1
PeroxiBase 4483
iPTMnet O74887
MaxQB O74887
PaxDb O74887
PRIDE O74887
EnsemblFungi SPCC576.03c.1
GeneID 2539572
KEGG spo:SPCC576.03c
EuPathDB FungiDB:SPCC576.03c
PomBase SPCC576.03c
HOGENOM HOG000022343
InParanoid O74887
KO K03386
OMA WYPKDFT
PhylomeDB O74887
Reactome R-SPO-5628897
R-SPO-6798695
PRO PR:O74887
Proteomes UP000002485
GO GO:0005737
GO:0005829
GO:0005634
GO:0004601
GO:0051920
GO:0008379
GO:0051082
GO:0045454
GO:0061692
GO:0042744
GO:0043433
GO:0036091
GO:0006979
InterPro IPR000866
IPR024706
IPR019479
IPR036249
IPR013766
Pfam PF10417
PF00578
PIRSF PIRSF000239
SUPFAM SSF52833
PROSITE PS51352

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0061692

cellular detoxification of hydrogen peroxide

PMID:24521463[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051920

peroxiredoxin activity

PMID:17409354[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

PMID:20356456[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

PMID:24521463[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

PMID:17409354[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

PMID:22245228[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • has_regulation_target:(PomBase:SPAC1783.07c)
  • part_of:(GO:0034599)

Seeded From UniProt

complete

involved_in

GO:0042744

hydrogen peroxide catabolic process

PMID:24521463[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042744

hydrogen peroxide catabolic process

PMID:22245228[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036091

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

PMID:24268782[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008379

thioredoxin peroxidase activity

PMID:20356456[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16823372[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22344694[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22245228[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16823372[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

PMID:17409354[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040309
MGI:MGI:1859815
PANTHER:PTN000073874
PomBase:SPCC576.03c
SGD:S000002861
SGD:S000004490
UniProtKB:P9WQB7

P

Seeded From UniProt

complete

involved_in

GO:0042744

hydrogen peroxide catabolic process

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189947
FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:109486
PANTHER:PTN000073874
PomBase:SPCC576.03c
UniProtKB:Q06830

P

Seeded From UniProt

complete

enables

GO:0008379

thioredoxin peroxidase activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189947
FB:FBgn0040308
FB:FBgn0040309
PANTHER:PTN000073874
PomBase:SPCC576.03c
SGD:S000002861
SGD:S000004490
UniProtKB:P32119
UniProtKB:Q06830
UniProtKB:Q8I5Q6
UniProtKB:Q8IL80

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:99523
PANTHER:PTN000073874
RGD:3838
RGD:620039
UniProtKB:P32119
UniProtKB:Q8I5Q6
UniProtKB:Q8IL80

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11384
FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:1859815
PANTHER:PTN000073874
RGD:3838
RGD:620039
SGD:S000004490
UniProtKB:Q8IL80

C

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013766

P

Seeded From UniProt

complete

enables

GO:0051920

peroxiredoxin activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019479

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866
InterPro:IPR019479

P

Seeded From UniProt

complete

enables

GO:0051920

peroxiredoxin activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.11.1.15

F

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0575

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0049

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Kim, JS et al. (2010) Distinct functional roles of peroxiredoxin isozymes and glutathione peroxidase from fission yeast, Schizosaccharomyces pombe. BMB Rep 43 170-5 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Paulo, E et al. (2014) A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase. Mol. Microbiol. 92 246-57 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Jara, M et al. (2007) The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast. Mol. Biol. Cell 18 2288-95 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Day, AM et al. (2012) Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival. Mol. Cell 45 398-408 PubMed GONUTS page
  5. ↑ Brown, JD et al. (2013) A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein. Cell Rep 5 1425-35 PubMed GONUTS page
  6. ↑ 6.0 6.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  7. ↑ Calvo, IA et al. (2012) The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2. Nucleic Acids Res. 40 4816-24 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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