SCHPO:TAZ1

Species (Taxon ID)	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s)	taz1 (synonyms: myb, myb1)
Protein Name(s)	Telomere length regulator taz1
External Links
UniProt	P79005
EMBL	Y09406 CU329670
PIR	T37772
RefSeq	NP_594047.1
PDB	2L3N 4ZMI 4ZMK
PDBsum	2L3N 4ZMI 4ZMK
ProteinModelPortal	P79005
SMR	P79005
BioGrid	278779
DIP	DIP-59072N
IntAct	P79005
STRING	4896.SPAC16A10.07c.1
iPTMnet	P79005
MaxQB	P79005
PaxDb	P79005
PRIDE	P79005
EnsemblFungi	SPAC16A10.07c.1
GeneID	2542313
KEGG	spo:SPAC16A10.07c
EuPathDB	FungiDB:SPAC16A10.07c
PomBase	SPAC16A10.07c
OMA	PAYCEIH
EvolutionaryTrace	P79005
PRO	PR:P79005
Proteomes	UP000002485
GO	GO:0005737 GO:0035974 GO:0000790 GO:0000784 GO:0005724 GO:0005634 GO:0110092 GO:0070187 GO:0042803 GO:0042162 GO:0034613 GO:0030466 GO:0006348 GO:0006302 GO:0070197 GO:0032121 GO:1902990 GO:0044820 GO:0000122 GO:0031848 GO:0101017 GO:0000723 GO:0031860 GO:0031627
CDD	cd11654
InterPro	IPR009057 IPR001005 IPR013867 IPR031902
Pfam	PF08558
SMART	SM00717
SUPFAM	SSF46689

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1902990	mitotic telomere maintenance via semi-conservative replication	PMID:26063574^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC1778.02	P		Seeded From UniProt	complete
involved_in	GO:1902990	mitotic telomere maintenance via semi-conservative replication	PMID:26063574^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPAC19G12.13c	P		Seeded From UniProt	complete
involved_in	GO:1902990	mitotic telomere maintenance via semi-conservative replication	PMID:16598261^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0110092	nucleus leading edge	PMID:11676924^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0007128)	Seeded From UniProt	complete
involved_in	GO:0101017	regulation of mitotic DNA replication initiation from late origin	PMID:22987637^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070197	meiotic attachment of telomere to nuclear envelope	PMID:17632059^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070187	shelterin complex	PMID:24244195^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044820	mitotic telomere tethering at nuclear periphery	PMID:22959349^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:9034194^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:27101289^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001496)	Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:15383525^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:10606652^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0035974	meiotic spindle pole body	PMID:11676924^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0007128)	Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	PMID:17289569^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPCC188.07	P		Seeded From UniProt	complete
part_of	GO:0034399	nuclear periphery	PMID:26744419^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032121	meiotic attachment of telomeric heterochromatin to spindle pole body	PMID:9572143^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032121	meiotic attachment of telomeric heterochromatin to spindle pole body	PMID:17632059^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031860	telomeric 3' overhang formation	PMID:16096639^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC1778.02	P		Seeded From UniProt	complete
involved_in	GO:0031848	protection from non-homologous end joining at telomere	PMID:16096639^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC1778.02	P		Seeded From UniProt	complete
involved_in	GO:0031848	protection from non-homologous end joining at telomere	PMID:23133674^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0000080)	Seeded From UniProt	complete
involved_in	GO:0031627	telomeric loop formation	PMID:15383525^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006348	chromatin silencing at telomere	PMID:9572142^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:12620220^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005724	nuclear telomeric heterochromatin	PMID:11676925^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16823372^[20]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22987637^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0002141)	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:20661445^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0001496)	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19214192^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:15383525^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:11676924^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:11676924^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	PomBase:SPBC1778.02	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16407326^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPBCPT2R1.08c)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16407326^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(PomBase:SPAC212.11)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009057	F		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013867	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013867	F		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:12018857^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Pan, L et al. (2015) Minishelterins separate telomere length regulation and end protection in fission yeast. Genes Dev. 29 1164-74 PubMed GONUTS page
↑ Miller, KM et al. (2006) Semi-conservative DNA replication through telomeres requires Taz1. Nature 440 824-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Chikashige, Y & Hiraoka, Y (2001) Telomere binding of the Rap1 protein is required for meiosis in fission yeast. Curr. Biol. 11 1618-23 PubMed GONUTS page
↑ ^4.0 ^4.1 Tazumi, A et al. (2012) Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast. Genes Dev. 26 2050-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Tomita, K & Cooper, JP (2007) The telomere bouquet controls the meiotic spindle. Cell 130 113-26 PubMed GONUTS page
↑ Chang, YT et al. (2013) Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension. PLoS Genet. 9 e1003936 PubMed GONUTS page
↑ Fujita, I et al. (2012) Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation. Curr. Biol. 22 1932-7 PubMed GONUTS page
↑ Cooper, JP et al. (1997) Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385 744-7 PubMed GONUTS page
↑ Sepsiova, R et al. (2016) Evolution of Telomeres in Schizosaccharomyces pombe and Its Possible Relationship to the Diversification of Telomere Binding Proteins. PLoS ONE 11 e0154225 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Tomaska, L et al. (2004) Taz1 binding to a fission yeast model telomere: formation of telomeric loops and higher order structures. J. Biol. Chem. 279 50764-72 PubMed GONUTS page
↑ Spink, KG et al. (2000) Sequence-specific binding of Taz1p dimers to fission yeast telomeric DNA. Nucleic Acids Res. 28 527-33 PubMed GONUTS page
↑ Sugiyama, T et al. (2007) SHREC, an effector complex for heterochromatic transcriptional silencing. Cell 128 491-504 PubMed GONUTS page
↑ Barrales, RR et al. (2016) Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2. Genes Dev. 30 133-48 PubMed GONUTS page
↑ Cooper, JP et al. (1998) Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination. Nature 392 828-31 PubMed GONUTS page
↑ ^15.0 ^15.1 Miller, KM et al. (2005) Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres. EMBO J. 24 3128-35 PubMed GONUTS page
↑ Fujita, I et al. (2012) Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe. PLoS ONE 7 e49151 PubMed GONUTS page
↑ Nimmo, ER et al. (1998) Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe. Nature 392 825-8 PubMed GONUTS page
↑ Miller, KM & Cooper, JP (2003) The telomere protein Taz1 is required to prevent and repair genomic DNA breaks. Mol. Cell 11 303-13 PubMed GONUTS page
↑ Kanoh, J & Ishikawa, F (2001) spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr. Biol. 11 1624-30 PubMed GONUTS page
↑ Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
↑ Rozenzhak, S et al. (2010) Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast. PLoS Genet. 6 e1001032 PubMed GONUTS page
↑ Moser, BA et al. (2009) Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres. EMBO J. 28 810-20 PubMed GONUTS page
↑ ^23.0 ^23.1 Hansen, KR et al. (2006) Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. Nucleic Acids Res. 34 78-88 PubMed GONUTS page
↑ Park, MJ et al. (2002) Fission yeast Rap1 homolog is a telomere-specific silencing factor and interacts with Taz1p. Mol. Cells 13 327-33 PubMed GONUTS page

[PMID:26063574-1] 1.0 ^1.1 Pan, L et al. (2015) Minishelterins separate telomere length regulation and end protection in fission yeast. Genes Dev. 29 1164-74 PubMed GONUTS page

[PMID:16598261-2] Miller, KM et al. (2006) Semi-conservative DNA replication through telomeres requires Taz1. Nature 440 824-8 PubMed GONUTS page

[PMID:11676924-3] 3.0 ^3.1 ^3.2 ^3.3 Chikashige, Y & Hiraoka, Y (2001) Telomere binding of the Rap1 protein is required for meiosis in fission yeast. Curr. Biol. 11 1618-23 PubMed GONUTS page

[PMID:22987637-4] 4.0 ^4.1 Tazumi, A et al. (2012) Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast. Genes Dev. 26 2050-62 PubMed GONUTS page

[PMID:17632059-5] 5.0 ^5.1 Tomita, K & Cooper, JP (2007) The telomere bouquet controls the meiotic spindle. Cell 130 113-26 PubMed GONUTS page

[PMID:24244195-6] Chang, YT et al. (2013) Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension. PLoS Genet. 9 e1003936 PubMed GONUTS page

[PMID:22959349-7] Fujita, I et al. (2012) Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation. Curr. Biol. 22 1932-7 PubMed GONUTS page

[PMID:9034194-8] Cooper, JP et al. (1997) Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385 744-7 PubMed GONUTS page

[PMID:27101289-9] Sepsiova, R et al. (2016) Evolution of Telomeres in Schizosaccharomyces pombe and Its Possible Relationship to the Diversification of Telomere Binding Proteins. PLoS ONE 11 e0154225 PubMed GONUTS page

[PMID:15383525-10] 10.0 ^10.1 ^10.2 Tomaska, L et al. (2004) Taz1 binding to a fission yeast model telomere: formation of telomeric loops and higher order structures. J. Biol. Chem. 279 50764-72 PubMed GONUTS page

[PMID:10606652-11] Spink, KG et al. (2000) Sequence-specific binding of Taz1p dimers to fission yeast telomeric DNA. Nucleic Acids Res. 28 527-33 PubMed GONUTS page

[PMID:17289569-12] Sugiyama, T et al. (2007) SHREC, an effector complex for heterochromatic transcriptional silencing. Cell 128 491-504 PubMed GONUTS page

[PMID:26744419-13] Barrales, RR et al. (2016) Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2. Genes Dev. 30 133-48 PubMed GONUTS page

[PMID:9572143-14] Cooper, JP et al. (1998) Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination. Nature 392 828-31 PubMed GONUTS page

[PMID:16096639-15] 15.0 ^15.1 Miller, KM et al. (2005) Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres. EMBO J. 24 3128-35 PubMed GONUTS page

[PMID:23133674-16] Fujita, I et al. (2012) Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe. PLoS ONE 7 e49151 PubMed GONUTS page

[PMID:9572142-17] Nimmo, ER et al. (1998) Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe. Nature 392 825-8 PubMed GONUTS page

[PMID:12620220-18] Miller, KM & Cooper, JP (2003) The telomere protein Taz1 is required to prevent and repair genomic DNA breaks. Mol. Cell 11 303-13 PubMed GONUTS page

[PMID:11676925-19] Kanoh, J & Ishikawa, F (2001) spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr. Biol. 11 1624-30 PubMed GONUTS page

[PMID:16823372-20] Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page

[PMID:20661445-21] Rozenzhak, S et al. (2010) Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast. PLoS Genet. 6 e1001032 PubMed GONUTS page

[PMID:19214192-22] Moser, BA et al. (2009) Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres. EMBO J. 28 810-20 PubMed GONUTS page

[PMID:16407326-23] 23.0 ^23.1 Hansen, KR et al. (2006) Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. Nucleic Acids Res. 34 78-88 PubMed GONUTS page

[PMID:12018857-24] Park, MJ et al. (2002) Fission yeast Rap1 homolog is a telomere-specific silencing factor and interacts with Taz1p. Mol. Cells 13 327-33 PubMed GONUTS page

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SCHPO:TAZ1

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