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SCHPO:MSH6

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) msh6
Protein Name(s) DNA mismatch repair protein msh6
External Links
UniProt O74502
EMBL AF207839
CU329672
PIR T41262
RefSeq NP_588344.1
ProteinModelPortal O74502
SMR O74502
BioGrid 275785
STRING 4896.SPCC285.16c.1
iPTMnet O74502
MaxQB O74502
PaxDb O74502
PRIDE O74502
EnsemblFungi SPCC285.16c.1
GeneID 2539215
KEGG spo:SPCC285.16c
EuPathDB FungiDB:SPCC285.16c
PomBase SPCC285.16c
HOGENOM HOG000189303
InParanoid O74502
KO K08737
OMA TPMMAQY
PhylomeDB O74502
Reactome R-SPO-5358565
PRO PR:O74502
Proteomes UP000002485
GO GO:0005829
GO:0032300
GO:0032301
GO:0005634
GO:0005524
GO:0003684
GO:0008094
GO:0000400
GO:0032137
GO:0035064
GO:0036297
GO:0043570
GO:0000710
GO:0006298
GO:0007095
GO:0032876
GO:0045910
GO:0051096
GO:0006290
GO:0043111
GO:0009411
Gene3D 3.30.420.110
3.40.1170.10
InterPro IPR015536
IPR007695
IPR017261
IPR000432
IPR007861
IPR007696
IPR016151
IPR036187
IPR007860
IPR036678
IPR027417
PANTHER PTHR11361:SF31
Pfam PF01624
PF05188
PF05192
PF05190
PF00488
PIRSF PIRSF037677
SMART SM00534
SM00533
SUPFAM SSF48334
SSF52540
SSF53150
SSF55271
PROSITE PS00486

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005829

cytosol

ECO:0000314

C

Source: GeneDB_SPombe

Missing: reference

GO:0005634

nucleus

ECO:0000314

C

Source: GeneDB_SPombe

Missing: reference

GO:0043570

maintenance of DNA repeat elements

ECO:0000315

P

Source: GeneDB_SPombe

Missing: reference

GO:0006298

mismatch repair

ECO:0000315

P

Source: GeneDB_SPombe

Missing: reference

GO:0000228

nuclear chromosome

GO_REF:0000033

ECO:0000250

PANTHER:PTHR11361_AN26

C

complete

GO:0000400

four-way junction DNA binding

GO_REF:0000033

ECO:0000250

PANTHER:PTHR11361_AN79

F

complete

GO:0000710

meiotic mismatch repair

GO_REF:0000033

ECO:0000250

PANTHER:PTHR11361_AN26

P

complete

GO:0003684

damaged DNA binding

GO_REF:0000033

ECO:0000250

PANTHER:PTHR11361_AN24

F

complete

GO:0005524

ATP binding

GO_REF:0000001

ECO:0000250

SGD:S000002504

F

complete

involved_in

GO:0043570

maintenance of DNA repeat elements

PMID:11333219[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0032137

guanine/thymine mispair binding

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000002504

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:11333218[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16823372[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16823372[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000002504

F

Seeded From UniProt

complete

involved_in

GO:0045910

negative regulation of DNA recombination

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1343961
PANTHER:PTN000145560
UniProtKB:P52701

P

Seeded From UniProt

complete

involved_in

GO:0043570

maintenance of DNA repeat elements

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145560
PomBase:SPCC285.16c
WB:WBGene00003422

P

Seeded From UniProt

complete

involved_in

GO:0036297

interstrand cross-link repair

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145560
SGD:S000002504

P

Seeded From UniProt

complete

involved_in

GO:0032876

negative regulation of DNA endoreduplication

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145560
UniProtKB:E1BYJ2

P

Seeded From UniProt

complete

contributes_to

GO:0032405

MutLalpha complex binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145560
UniProtKB:P52701

F

Seeded From UniProt

complete

contributes_to

GO:0032357

oxidized purine DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145560
UniProtKB:P52701

F

Seeded From UniProt

complete

part_of

GO:0032301

MutSalpha complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1343961
PANTHER:PTN000145560
SGD:S000002504
UniProtKB:P52701

C

Seeded From UniProt

complete

part_of

GO:0032300

mismatch repair complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779

C

Seeded From UniProt

complete

contributes_to

GO:0032143

single thymine insertion binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145560
UniProtKB:P52701

F

Seeded From UniProt

complete

contributes_to

GO:0030983

mismatched DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
MGI:MGI:1343961
PANTHER:PTN002260779
SGD:S000000688
SGD:S000001162
SGD:S000002504
SGD:S000005450
UniProtKB:P20585
UniProtKB:P43246
UniProtKB:P52701
ZFIN:ZDB-GENE-020905-3
ZFIN:ZDB-GENE-040426-2932

F

Seeded From UniProt

complete

enables

GO:0008094

DNA-dependent ATPase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260779
SGD:S000001162

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
FB:FBgn0015546
MGI:MGI:101816
MGI:MGI:109519
MGI:MGI:1343961
PANTHER:PTN000145505
PomBase:SPBC19G7.01c
PomBase:SPCC285.16c
SGD:S000000688
SGD:S000001162
SGD:S000002504
SGD:S000005450
TAIR:locus:2095097
UniProtKB:P20585
UniProtKB:P43246
UniProtKB:P52701
WB:WBGene00003418
WB:WBGene00003422

P

Seeded From UniProt

complete

involved_in

GO:0006290

pyrimidine dimer repair

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145560
UniProtKB:O04716

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450

F

Seeded From UniProt

complete

involved_in

GO:0000710

meiotic mismatch repair

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036486
PANTHER:PTN000145560
SGD:S000002504

P

Seeded From UniProt

complete

enables

GO:0000400

four-way junction DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145560
SGD:S000002504
UniProtKB:P52701

F

Seeded From UniProt

complete

enables

GO:0000400

four-way junction DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145560
SGD:S000002504

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR016151
InterPro:IPR036678

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR016151
InterPro:IPR017261
InterPro:IPR036678

P

Seeded From UniProt

complete

enables

GO:0030983

mismatched DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR016151
InterPro:IPR017261
InterPro:IPR036678

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Mansour, AA et al. (2001) Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Genetics 158 77-85 PubMed GONUTS page
  2. ↑ Tornier, C et al. (2001) Requirement for Msh6, but not for Swi4 (Msh3), in Msh2-dependent repair of base-base mismatches and mononucleotide loops in Schizosaccharomyces pombe. Genetics 158 65-75 PubMed GONUTS page
  3. ↑ 3.0 3.1 Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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