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SCHPO:MSH3

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Species (Taxon ID) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). (284812)
Gene Name(s) msh3 (synonyms: swi4)
Protein Name(s) DNA mismatch repair protein msh3

Mating-type switching protein swi4 MutS protein homolog 3

External Links
UniProt P26359
EMBL X61306
CU329670
PIR S22569
RefSeq NP_593952.1
ProteinModelPortal P26359
SMR P26359
STRING 4896.SPAC8F11.03.1
iPTMnet P26359
PaxDb P26359
PRIDE P26359
GeneID 2543392
KEGG spo:SPAC8F11.03
PomBase SPAC8F11.03
InParanoid P26359
KO K08736
PhylomeDB P26359
Reactome R-SPO-5358606
PRO PR:P26359
Proteomes UP000002485
GO GO:0032300
GO:0032302
GO:0000228
GO:0005634
GO:0035861
GO:0005524
GO:0003684
GO:0008094
GO:0000406
GO:0030983
GO:0032357
GO:0006281
GO:0007534
GO:0061500
GO:0043570
GO:0000710
GO:0006298
GO:0006312
GO:0051096
GO:0007131
GO:0000735
GO:0043111
Gene3D 3.30.420.110
3.40.1170.10
InterPro IPR007695
IPR017261
IPR000432
IPR007861
IPR007696
IPR016151
IPR036187
IPR007860
IPR036678
IPR027417
Pfam PF01624
PF05188
PF05192
PF05190
PF00488
PIRSF PIRSF037677
SMART SM00534
SM00533
SUPFAM SSF48334
SSF52540
SSF55271
PROSITE PS00486

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0061500

gene conversion at mating-type locus, termination of copy-synthesis

PMID:1317550[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043570

maintenance of DNA repeat elements

PMID:11333219[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035861

site of double-strand break

PMID:23628481[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007534

gene conversion at mating-type locus

PMID:6587363[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007131

reciprocal meiotic recombination

PMID:11333218[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000051

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16823372[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000050

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR000432

F

Seeded From UniProt

complete

enables

GO:0000406

double-strand/single-strand DNA junction binding

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000000688

F

Seeded From UniProt

complete

contributes_to

GO:0000404

heteroduplex DNA loop binding

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000000688

F

Seeded From UniProt

complete

contributes_to

GO:0000403

Y-form DNA binding

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000000688

F

Seeded From UniProt

complete

part_of

GO:0000228

nuclear chromosome

GO_REF:0000024

ECO:0000266

sequence orthology evidence used in manual assertion

SGD:S000000688

C

Seeded From UniProt

complete

involved_in

GO:0051096

positive regulation of helicase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145759
UniProtKB:P20585

P

Seeded From UniProt

complete

involved_in

GO:0043570

maintenance of DNA repeat elements

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145759
PomBase:SPAC8F11.03
UniProtKB:P20585

P

Seeded From UniProt

complete

involved_in

GO:0043111

replication fork arrest

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145759
SGD:S000000688

P

Seeded From UniProt

complete

part_of

GO:0032302

MutSbeta complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145759
SGD:S000000688
UniProtKB:P20585

C

Seeded From UniProt

complete

part_of

GO:0032300

mismatch repair complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779

C

Seeded From UniProt

complete

enables

GO:0032135

DNA insertion or deletion binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145759
SGD:S000000688

F

Seeded From UniProt

complete

contributes_to

GO:0030983

mismatched DNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
MGI:MGI:1343961
PANTHER:PTN002260779
SGD:S000000688
SGD:S000001162
SGD:S000002504
SGD:S000005450
UniProtKB:P20585
UniProtKB:P43246
UniProtKB:P52701
ZFIN:ZDB-GENE-020905-3
ZFIN:ZDB-GENE-040426-2932

F

Seeded From UniProt

complete

enables

GO:0008094

DNA-dependent ATPase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260779
SGD:S000001162

F

Seeded From UniProt

complete

involved_in

GO:0007131

reciprocal meiotic recombination

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145759
PomBase:SPAC8F11.03

P

Seeded From UniProt

complete

involved_in

GO:0006312

mitotic recombination

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145759
SGD:S000000688

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
FB:FBgn0015546
MGI:MGI:101816
MGI:MGI:109519
MGI:MGI:1343961
PANTHER:PTN000145505
PomBase:SPBC19G7.01c
PomBase:SPCC285.16c
SGD:S000000688
SGD:S000001162
SGD:S000002504
SGD:S000005450
TAIR:locus:2095097
UniProtKB:P20585
UniProtKB:P43246
UniProtKB:P52701
WB:WBGene00003418
WB:WBGene00003422

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450

F

Seeded From UniProt

complete

involved_in

GO:0000735

removal of nonhomologous ends

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145759
SGD:S000000688

P

Seeded From UniProt

complete

involved_in

GO:0000710

meiotic mismatch repair

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145759
SGD:S000000688

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR016151
InterPro:IPR036678

F

Seeded From UniProt

complete

enables

GO:0030983

mismatched DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR016151
InterPro:IPR017261
InterPro:IPR036678

F

Seeded From UniProt

complete

NOT|involved_in

GO:0006298

mismatch repair

PMID:11333218[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Fleck, O et al. (1992) The swi4+ gene of Schizosaccharomyces pombe encodes a homologue of mismatch repair enzymes. Nucleic Acids Res. 20 2271-8 PubMed GONUTS page
  2. ↑ Mansour, AA et al. (2001) Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors. Genetics 158 77-85 PubMed GONUTS page
  3. ↑ Yu, Y et al. (2013) A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks. DNA Repair (Amst.) 12 433-43 PubMed GONUTS page
  4. ↑ Egel, R et al. (1984) Genes required for initiation and resolution steps of mating-type switching in fission yeast. Proc. Natl. Acad. Sci. U.S.A. 81 3481-5 PubMed GONUTS page
  5. ↑ 5.0 5.1 Tornier, C et al. (2001) Requirement for Msh6, but not for Swi4 (Msh3), in Msh2-dependent repair of base-base mismatches and mononucleotide loops in Schizosaccharomyces pombe. Genetics 158 65-75 PubMed GONUTS page
  6. ↑ Matsuyama, A et al. (2006) ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nat. Biotechnol. 24 841-7 PubMed GONUTS page
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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