RAT:SODC

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Sod1
Protein Name(s)	Superoxide dismutase [Cu-Zn]
External Links
UniProt	P07632
EMBL	Y00404 M25157 X05634 Z21917 Z21918 Z21919 Z21920 BC082800
PIR	JC1192
RefSeq	NP_058746.1
UniGene	Rn.6059
ProteinModelPortal	P07632
SMR	P07632
BioGrid	246910
IntAct	P07632
MINT	MINT-6612994
STRING	10116.ENSRNOP00000002885
PhosphoSite	P07632
PaxDb	P07632
PRIDE	P07632
Ensembl	ENSRNOT00000002885
GeneID	24786
KEGG	rno:24786
UCSC	RGD:3731
CTD	6647
RGD	3731
eggNOG	COG2032
GeneTree	ENSGT00530000063226
HOGENOM	HOG000263447
HOVERGEN	HBG000062
InParanoid	P07632
KO	K04565
OMA	NDPNAKR
OrthoDB	EOG776SR4
PhylomeDB	P07632
TreeFam	TF105131
Reactome	REACT_213899
NextBio	604408
PRO	PR:P07632
Proteomes	UP000002494
ExpressionAtlas	P07632
Genevestigator	P07632
GO	GO:0005737 GO:0031410 GO:0005829 GO:0032839 GO:0031045 GO:0031012 GO:0005576 GO:0005615 GO:0070062 GO:0005758 GO:0005739 GO:0043005 GO:0043025 GO:0005634 GO:0005777 GO:0005886 GO:0043234 GO:0030141 GO:0051087 GO:0005507 GO:0019899 GO:0030346 GO:0004784 GO:0008270 GO:0000187 GO:0008089 GO:0006309 GO:0060088 GO:0007569 GO:0006879 GO:0071318 GO:0071276 GO:0034599 GO:0035865 GO:0006302 GO:0007566 GO:0006749 GO:0060047 GO:0050665 GO:0007626 GO:0046716 GO:0002262 GO:0043066 GO:0045541 GO:0043524 GO:0060052 GO:0001541 GO:0032287 GO:0043085 GO:0001819 GO:1902177 GO:0032930 GO:0072593 GO:0008217 GO:0051881 GO:0040014 GO:0045859 GO:0032314 GO:0060087 GO:0019430 GO:0001975 GO:0046677 GO:0097332 GO:0048678 GO:0034465 GO:0046688 GO:0042493 GO:0045471 GO:0009408 GO:0042542 GO:0031667 GO:0010033 GO:0006979 GO:0000303 GO:0001895 GO:0008090 GO:0007605 GO:0007283 GO:0042554 GO:0006801 GO:0019226
Gene3D	2.60.40.200
InterPro	IPR018152 IPR001424
Pfam	PF00080
PRINTS	PR00068
SUPFAM	SSF49329
PROSITE	PS00087 PS00332

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005764	lysosome	PMID:7096343^[1]	ECO:0000314			C	Fig 4	complete CACAO 6669
part_of	GO:0005764	lysosome	PMID:7096343^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
involved_in	GO:0060088	auditory receptor cell stereocilium organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0060087	relaxation of vascular smooth muscle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0060052	neurofilament cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	F	Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0045859	regulation of protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
involved_in	GO:0045541	negative regulation of cholesterol biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	PMID:17324120^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
involved_in	GO:0032287	peripheral nervous system myelin maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
enables	GO:0030346	protein phosphatase 2B binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	F	Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0019226	transmission of nerve impulse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	F	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:19686298^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	F	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	F	Seeded From UniProt	complete
involved_in	GO:0002262	myeloid cell homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0001895	retina homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0000303	response to superoxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00441	P	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08228	P	Seeded From UniProt	complete
involved_in	GO:0097332	response to antipsychotic drug	PMID:12111809^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071318	cellular response to ATP	PMID:22572742^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	PMID:17584760^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	PMID:15880490^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	PMID:12514262^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	PMID:10640619^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046688	response to copper ion	PMID:14747682^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046688	response to copper ion	PMID:12514262^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	PMID:21590694^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:11961082^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:10640619^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:17324120^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035865	cellular response to potassium ion	PMID:17403136^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:22758933^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034465	response to carbon monoxide	PMID:19580685^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19686298^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	PMID:12067840^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	PMID:21562236^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031045	dense core granule	PMID:17403136^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0030346	protein phosphatase 2B binding	PMID:17324120^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:22572742^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23061969^[18]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3244	F	Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	PMID:21757500^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	PMID:12514262^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	PMID:10640619^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:17663478^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	PMID:12514262^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	PMID:10640619^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:17394422^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:16337891^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16372329^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16372329^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:22572742^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:12514262^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	PMID:17324120^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	PMID:2703531^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	PMID:12514262^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	PMID:10640619^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	PMID:18452277^[25]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033631 MGI:MGI:98351 PANTHER:PTN000000113 PomBase:SPAC22E12.04 RGD:3731 UniProtKB:P00442 WB:WBGene00004930	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002467128 UniProtKB:P00441 WB:WBGene00004930	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002558032 RGD:3731 UniProtKB:P00441	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002467128 RGD:3731 UniProtKB:P00441	C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13419 PANTHER:PTN000000113 RGD:3731 UniProtKB:O14618 UniProtKB:P00441 UniProtKB:P00442 WB:WBGene00004930	F	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13419 FB:FBgn0003462 FB:FBgn0033631 MGI:MGI:103181 MGI:MGI:98351 PANTHER:PTN000000113 PomBase:SPAC821.10c RGD:3731 RGD:3733 SGD:S000003865 TAIR:locus:2025595 TAIR:locus:2046168 UniProtKB:P00441 UniProtKB:P00442 UniProtKB:P9WGE9 WB:WBGene00004930 WB:WBGene00004933 dictyBase:DDB_G0267420 dictyBase:DDB_G0282993	F	Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008090	C	Seeded From UniProt	complete
involved_in	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	F	Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	F	Seeded From UniProt	complete
involved_in	GO:0045859	regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
involved_in	GO:0045541	negative regulation of cholesterol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	F	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
involved_in	GO:0032930	positive regulation of superoxide anion generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
enables	GO:0030346	protein phosphatase 2B binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	F	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	F	Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	F	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	F	Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
involved_in	GO:0000303	response to superoxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P00441 ensembl:ENSP00000270142	P	Seeded From UniProt	complete
involved_in	GO:0060088	auditory receptor cell stereocilium organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0060087	relaxation of vascular smooth muscle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0060052	neurofilament cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0050665	hydrogen peroxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0032287	peripheral nervous system myelin maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0019226	transmission of nerve impulse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0008090	retrograde axonal transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	C	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	F	Seeded From UniProt	complete
involved_in	GO:0002262	myeloid cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0001895	retina homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0000303	response to superoxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0000302	response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08228 ensembl:ENSMUSP00000023707	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HWC9 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HWC9 ensembl:ENSP00000270142	C	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018152	F	Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001424 InterPro:IPR036423	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001424 InterPro:IPR036423	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018152	P	Seeded From UniProt	complete
enables	GO:0004784	superoxide dismutase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.15.1.1	F	Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	PMID:2703531^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:2703531^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	PMID:2703531^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:15337829^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0049	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Geller, BL & Winge, DR (1982) Rat liver Cu,Zn-superoxide dismutase. Subcellular location in lysosomes. J. Biol. Chem. 257 8945-52 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Agbas, A et al. (2007) Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. Biochem. J. 405 51-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Islinger, M et al. (2009) Hitchhiking of Cu/Zn superoxide dismutase to peroxisomes--evidence for a natural piggyback import mechanism in mammals. Traffic 10 1711-21 PubMed GONUTS page
↑ Bai, O et al. (2002) Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal. J. Neurosci. Res. 69 278-83 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Polazzi, E et al. (2013) Copper-zinc superoxide dismutase (SOD1) is released by microglial cells and confers neuroprotection against 6-OHDA neurotoxicity. Neurosignals 21 112-28 PubMed GONUTS page
↑ Chou, DK et al. (2007) Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts. Toxicol. Sci. 99 267-76 PubMed GONUTS page
↑ Webber, DS et al. (2005) Limiting iron availability confers neuroprotection from chronic mild carbon monoxide exposure in the developing auditory system of the rat. J. Neurosci. Res. 80 620-33 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Bertinato, J et al. (2003) Copper deficiency induces the upregulation of the copper chaperone for Cu/Zn superoxide dismutase in weanling male rats. J. Nutr. 133 28-31 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Kim, H et al. (2000) Changes of hippocampal Cu/Zn-superoxide dismutase after kainate treatment in the rat. Brain Res. 853 215-26 PubMed GONUTS page
↑ Reeves, PG et al. (2004) Contrasting and cooperative effects of copper and iron deficiencies in male rats fed different concentrations of manganese and different sources of sulfur amino acids in an AIN-93G-based diet. J. Nutr. 134 416-25 PubMed GONUTS page
↑ Wergeland, A et al. (2011) Dietary red palm oil protects the heart against the cytotoxic effects of anthracycline. Cell Biochem. Funct. 29 356-64 PubMed GONUTS page
↑ Tatton, WG et al. (2002) Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells. J. Pharmacol. Exp. Ther. 301 753-64 PubMed GONUTS page
↑ ^13.0 ^13.1 Santillo, M et al. (2007) Evidence of calcium- and SNARE-dependent release of CuZn superoxide dismutase from rat pituitary GH3 cells and synaptosomes in response to depolarization. J. Neurochem. 102 679-85 PubMed GONUTS page
↑ Seshadri, G et al. (2012) Characterization of superoxide dismutases in cardiac progenitor cells demonstrates a critical role for manganese superoxide dismutase. Stem Cells Dev. 21 3136-46 PubMed GONUTS page
↑ Lopez, IA et al. (2009) Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air). BMC Neurosci 10 53 PubMed GONUTS page
↑ Sreekumar, R et al. (2002) Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Am. J. Physiol. Endocrinol. Metab. 283 E38-43 PubMed GONUTS page
↑ Zhang, X et al. (2011) A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats. J. Nutr. 141 1254-9 PubMed GONUTS page
↑ Chen, X et al. (2012) SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI). J Neuroinflammation 9 237 PubMed GONUTS page
↑ Andreo, U et al. (2011) Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. FASEB J. 25 3554-60 PubMed GONUTS page
↑ Boulos, S et al. (2007) Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury. J. Neurosci. Res. 85 3089-97 PubMed GONUTS page
↑ Iñarrea, P et al. (2007) Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis. Biochem. J. 405 173-9 PubMed GONUTS page
↑ Li, Q et al. (2006) A possible cooperation of SOD1 and cytochrome c in mitochondria-dependent apoptosis. Free Radic. Biol. Med. 40 173-81 PubMed GONUTS page
↑ ^23.0 ^23.1 Pechenino, AS & Brown, TR (2006) Superoxide dismutase in the prostate lobes of aging Brown Norway rats. Prostate 66 522-35 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Hass, MA et al. (1989) Rat lung Cu,Zn superoxide dismutase. Isolation and sequence of a full-length cDNA and studies of enzyme induction. J. Clin. Invest. 83 1241-6 PubMed GONUTS page
↑ Kobeissy, FH et al. (2008) Psychoproteomic analysis of rat cortex following acute methamphetamine exposure. J. Proteome Res. 7 1971-83 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ West, EC & Prohaska, JR (2004) Cu,Zn-superoxide dismutase is lower and copper chaperone CCS is higher in erythrocytes of copper-deficient rats and mice. Exp. Biol. Med. (Maywood) 229 756-64 PubMed GONUTS page

[PMID:7096343-1] 1.0 ^1.1 Geller, BL & Winge, DR (1982) Rat liver Cu,Zn-superoxide dismutase. Subcellular location in lysosomes. J. Biol. Chem. 257 8945-52 PubMed GONUTS page

[PMID:17324120-2] 2.0 ^2.1 ^2.2 ^2.3 Agbas, A et al. (2007) Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. Biochem. J. 405 51-9 PubMed GONUTS page

[PMID:19686298-3] 3.0 ^3.1 Islinger, M et al. (2009) Hitchhiking of Cu/Zn superoxide dismutase to peroxisomes--evidence for a natural piggyback import mechanism in mammals. Traffic 10 1711-21 PubMed GONUTS page

[PMID:12111809-4] Bai, O et al. (2002) Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal. J. Neurosci. Res. 69 278-83 PubMed GONUTS page

[PMID:22572742-5] 5.0 ^5.1 ^5.2 Polazzi, E et al. (2013) Copper-zinc superoxide dismutase (SOD1) is released by microglial cells and confers neuroprotection against 6-OHDA neurotoxicity. Neurosignals 21 112-28 PubMed GONUTS page

[PMID:17584760-6] Chou, DK et al. (2007) Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts. Toxicol. Sci. 99 267-76 PubMed GONUTS page

[PMID:15880490-7] Webber, DS et al. (2005) Limiting iron availability confers neuroprotection from chronic mild carbon monoxide exposure in the developing auditory system of the rat. J. Neurosci. Res. 80 620-33 PubMed GONUTS page

[PMID:12514262-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Bertinato, J et al. (2003) Copper deficiency induces the upregulation of the copper chaperone for Cu/Zn superoxide dismutase in weanling male rats. J. Nutr. 133 28-31 PubMed GONUTS page

[PMID:10640619-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Kim, H et al. (2000) Changes of hippocampal Cu/Zn-superoxide dismutase after kainate treatment in the rat. Brain Res. 853 215-26 PubMed GONUTS page

[PMID:14747682-10] Reeves, PG et al. (2004) Contrasting and cooperative effects of copper and iron deficiencies in male rats fed different concentrations of manganese and different sources of sulfur amino acids in an AIN-93G-based diet. J. Nutr. 134 416-25 PubMed GONUTS page

[PMID:21590694-11] Wergeland, A et al. (2011) Dietary red palm oil protects the heart against the cytotoxic effects of anthracycline. Cell Biochem. Funct. 29 356-64 PubMed GONUTS page

[PMID:11961082-12] Tatton, WG et al. (2002) Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells. J. Pharmacol. Exp. Ther. 301 753-64 PubMed GONUTS page

[PMID:17403136-13] 13.0 ^13.1 Santillo, M et al. (2007) Evidence of calcium- and SNARE-dependent release of CuZn superoxide dismutase from rat pituitary GH3 cells and synaptosomes in response to depolarization. J. Neurochem. 102 679-85 PubMed GONUTS page

[PMID:22758933-14] Seshadri, G et al. (2012) Characterization of superoxide dismutases in cardiac progenitor cells demonstrates a critical role for manganese superoxide dismutase. Stem Cells Dev. 21 3136-46 PubMed GONUTS page

[PMID:19580685-15] Lopez, IA et al. (2009) Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air). BMC Neurosci 10 53 PubMed GONUTS page

[PMID:12067840-16] Sreekumar, R et al. (2002) Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Am. J. Physiol. Endocrinol. Metab. 283 E38-43 PubMed GONUTS page

[PMID:21562236-17] Zhang, X et al. (2011) A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats. J. Nutr. 141 1254-9 PubMed GONUTS page

[PMID:23061969-18] Chen, X et al. (2012) SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI). J Neuroinflammation 9 237 PubMed GONUTS page

[PMID:21757500-19] Andreo, U et al. (2011) Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. FASEB J. 25 3554-60 PubMed GONUTS page

[PMID:17663478-20] Boulos, S et al. (2007) Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury. J. Neurosci. Res. 85 3089-97 PubMed GONUTS page

[PMID:17394422-21] Iñarrea, P et al. (2007) Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis. Biochem. J. 405 173-9 PubMed GONUTS page

[PMID:16337891-22] Li, Q et al. (2006) A possible cooperation of SOD1 and cytochrome c in mitochondria-dependent apoptosis. Free Radic. Biol. Med. 40 173-81 PubMed GONUTS page

[PMID:16372329-23] 23.0 ^23.1 Pechenino, AS & Brown, TR (2006) Superoxide dismutase in the prostate lobes of aging Brown Norway rats. Prostate 66 522-35 PubMed GONUTS page

[PMID:2703531-24] 24.0 ^24.1 ^24.2 ^24.3 Hass, MA et al. (1989) Rat lung Cu,Zn superoxide dismutase. Isolation and sequence of a full-length cDNA and studies of enzyme induction. J. Clin. Invest. 83 1241-6 PubMed GONUTS page

[PMID:18452277-25] Kobeissy, FH et al. (2008) Psychoproteomic analysis of rat cortex following acute methamphetamine exposure. J. Proteome Res. 7 1971-83 PubMed GONUTS page

[PMID:21873635-26] 26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15337829-27] West, EC & Prohaska, JR (2004) Cu,Zn-superoxide dismutase is lower and copper chaperone CCS is higher in erythrocytes of copper-deficient rats and mice. Exp. Biol. Med. (Maywood) 229 756-64 PubMed GONUTS page

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RAT:SODC

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