RAT:S10A9

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	S100a9 (synonyms: Mrp14)
Protein Name(s)	Protein S100-A9 Calgranulin-B Migration inhibitory factor-related protein 14 MRP-14 p14 Myeloid-related protein 14 S100 calcium-binding protein A9
External Links
UniProt	P50116
EMBL	L18948 AB118215
PIR	JN0686
RefSeq	NP_446039.1
UniGene	Rn.6703
ProteinModelPortal	P50116
SMR	P50116
STRING	10116.ENSRNOP00000015351
PRIDE	P50116
Ensembl	ENSRNOT00000015351
GeneID	94195
KEGG	rno:94195
UCSC	RGD:620267
CTD	6280
RGD	620267
eggNOG	NOG47012
GeneTree	ENSGT00760000119034
HOGENOM	HOG000246968
HOVERGEN	HBG001479
InParanoid	P50116
OMA	HEKMHEN
OrthoDB	EOG73807B
PhylomeDB	P50116
TreeFam	TF332727
NextBio	617850
PRO	PR:P50116
Proteomes	UP000002494
Genevestigator	P50116
GO	GO:0005737 GO:0005856 GO:0005615 GO:0070062 GO:0005634 GO:0005886 GO:0016209 GO:0050544 GO:0005509 GO:0008270 GO:0031532 GO:0006919 GO:0006914 GO:0002544 GO:0045087 GO:0002523 GO:0070488 GO:0030593 GO:0050729 GO:2001244 GO:0045113 GO:0045471 GO:0032496 GO:0010043
Gene3D	1.10.238.10
InterPro	IPR011992 IPR002048 IPR028475 IPR001751 IPR013787
PANTHER	PTHR11639:SF53
Pfam	PF01023
PROSITE	PS50222 PS00303

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0035425	autocrine signaling	PMID:27312849^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q4FZY1	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:23825416^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002611) regulates_o_occurs_in:(UBERON:0000044)	Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06702	P		Seeded From UniProt	complete
involved_in	GO:0070488	neutrophil aggregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06702	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06702	P		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06702	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06702	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06702	P		Seeded From UniProt	complete
involved_in	GO:0002523	leukocyte migration involved in inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06702	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:17207109^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:17207109^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010043	response to zinc ion	PMID:19111725^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15221771^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002544	chronic inflammatory response	PMID:8343166^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016209	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001751 InterPro:IPR002048 InterPro:IPR028475	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028475	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028475	F		Seeded From UniProt	complete
enables	GO:0035662	Toll-like receptor 4 binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028475	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028475	P		Seeded From UniProt	complete
enables	GO:0050544	arachidonic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028475	F		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028475	P		Seeded From UniProt	complete
enables	GO:0050786	RAGE receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028475	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0049	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Okada, K et al. (2016) CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions. J. Leukoc. Biol. 100 1093-1104 PubMed GONUTS page
↑ Roet, KC et al. (2013) A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. J. Neurosci. 33 11116-35 PubMed GONUTS page
↑ ^3.0 ^3.1 Zhang, P et al. (2007) Alcohol intoxication inhibits pulmonary S100A8 and S100A9 expression in rats challenged with intratracheal lipopolysaccharide. Alcohol. Clin. Exp. Res. 31 113-21 PubMed GONUTS page
↑ Taccioli, C et al. (2009) Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology 136 953-66 PubMed GONUTS page
↑ Signor, L et al. (2004) Two-dimensional electrophoresis protein profiling and identification in rat bronchoalveolar lavage fluid following allergen and endotoxin challenge. Proteomics 4 2101-10 PubMed GONUTS page
↑ Imamichi, T et al. (1993) Expression and cloning of migration inhibitory factor-related protein (MRP)8 and MRP14 in arthritis-susceptible rats. Biochem. Biophys. Res. Commun. 194 819-25 PubMed GONUTS page

[PMID:27312849-1] Okada, K et al. (2016) CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions. J. Leukoc. Biol. 100 1093-1104 PubMed GONUTS page

[PMID:23825416-2] Roet, KC et al. (2013) A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. J. Neurosci. 33 11116-35 PubMed GONUTS page

[PMID:17207109-3] 3.0 ^3.1 Zhang, P et al. (2007) Alcohol intoxication inhibits pulmonary S100A8 and S100A9 expression in rats challenged with intratracheal lipopolysaccharide. Alcohol. Clin. Exp. Res. 31 113-21 PubMed GONUTS page

[PMID:19111725-4] Taccioli, C et al. (2009) Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology 136 953-66 PubMed GONUTS page

[PMID:15221771-5] Signor, L et al. (2004) Two-dimensional electrophoresis protein profiling and identification in rat bronchoalveolar lavage fluid following allergen and endotoxin challenge. Proteomics 4 2101-10 PubMed GONUTS page

[PMID:8343166-6] Imamichi, T et al. (1993) Expression and cloning of migration inhibitory factor-related protein (MRP)8 and MRP14 in arthritis-susceptible rats. Biochem. Biophys. Res. Commun. 194 819-25 PubMed GONUTS page

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RAT:S10A9

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