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RAT:PRS8
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Psmc5 (synonyms: Sug1) | |
| Protein Name(s) | 26S protease regulatory subunit 8
26S proteasome AAA-ATPase subunit RPT6 Proteasome 26S subunit ATPase 5 Proteasome subunit p45 Thyroid hormone receptor-interacting protein 1 TRIP1 p45/SUG | |
| External Links | ||
| UniProt | P62198 | |
| EMBL | D83521 AB000491 AB000493 BC058462 | |
| PIR | T43799 | |
| RefSeq | NP_112411.1 | |
| UniGene | Rn.10972 | |
| ProteinModelPortal | P62198 | |
| SMR | P62198 | |
| BioGrid | 249685 | |
| IntAct | P62198 | |
| MINT | MINT-4108806 | |
| PhosphoSite | P62198 | |
| World-2DPAGE | 0004:P62198 | |
| PaxDb | P62198 | |
| PRIDE | P62198 | |
| Ensembl | ENSRNOT00000013997 | |
| GeneID | 81827 | |
| KEGG | rno:81827 | |
| UCSC | RGD:708376 | |
| CTD | 5705 | |
| RGD | 708376 | |
| eggNOG | COG1222 | |
| GeneTree | ENSGT00550000074947 | |
| HOGENOM | HOG000225143 | |
| HOVERGEN | HBG000109 | |
| InParanoid | P62198 | |
| KO | K03066 | |
| OMA | VMGTKKV | |
| OrthoDB | EOG7TF78Z | |
| PhylomeDB | P62198 | |
| Reactome | REACT_194781 REACT_196424 REACT_198391 REACT_199194 REACT_199197 REACT_199247 REACT_199254 REACT_204983 REACT_206488 REACT_206997 REACT_211117 REACT_212486 REACT_220232 REACT_227706 REACT_235738 REACT_236654 REACT_240793 REACT_244609 REACT_245329 REACT_246662 REACT_247625 REACT_252335 REACT_255131 REACT_257365 REACT_259430 REACT_269272 REACT_269753 REACT_270919 | |
| NextBio | 615767 | |
| PRO | PR:P62198 | |
| Proteomes | UP000002494 | |
| ExpressionAtlas | P62198 | |
| Genevestigator | P62198 | |
| GO | GO:0072562 GO:0005737 GO:0031410 GO:0031597 GO:0070062 GO:0016234 GO:0016020 GO:0031595 GO:0005634 GO:0022624 GO:0000502 GO:0005838 GO:0005524 GO:0016887 GO:0017025 GO:0031531 GO:0008134 GO:0006200 GO:0045892 GO:0090261 GO:0043161 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR005937 IPR003593 IPR003959 IPR003960 IPR027417 | |
| Pfam | PF00004 | |
| SMART | SM00382 | |
| SUPFAM | SSF52540 | |
| TIGRFAMs | TIGR01242 | |
| PROSITE | PS00674 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0050804 |
modulation of chemical synaptic transmission |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002608) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000502 |
proteasome complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0099576 |
regulation of protein catabolic process at postsynapse, modulating synaptic transmission |
ECO:0000305 |
curator inference used in manual assertion |
GO:0000502,GO:0050804,GO:0098794 |
P |
|
Seeded From UniProt |
complete | |
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031531 |
thyrotropin-releasing hormone receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0022624 |
proteasome accessory complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000502 |
proteasome complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090261 |
positive regulation of inclusion body assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031597 |
cytosolic proteasome complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031595 |
nuclear proteasome complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017025 |
TBP-class protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:68981 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016887 |
ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016234 |
inclusion body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098794 |
postsynapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000553337 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050804 |
modulation of chemical synaptic transmission |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000553337 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045899 |
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000553334 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031597 |
cytosolic proteasome complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000553334 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031595 |
nuclear proteasome complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000553334 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017025 |
TBP-class protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000553334 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008540 |
proteasome regulatory particle, base subcomplex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0020369 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901800 |
positive regulation of proteasomal protein catabolic process |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0036402 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62195 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031531 |
thyrotropin-releasing hormone receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62195 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62195 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62195 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62195 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62195 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62195 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000502 |
proteasome complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62195 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62196 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0022624 |
proteasome accessory complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62196 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005838 |
proteasome regulatory particle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62196 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P62196 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030163 |
protein catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036402 |
proteasome-activating ATPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000502 |
proteasome complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Djakovic, SN et al. (2012) Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neurons. J. Neurosci. 32 5126-31 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Rousseau, E et al. (2009) Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones. J. Biol. Chem. 284 1917-29 PubMed GONUTS page
- ↑ Wang, W et al. (1996) Mammalian Sug1 and c-Fos in the nuclear 26S proteasome. Proc. Natl. Acad. Sci. U.S.A. 93 8236-40 PubMed GONUTS page
- ↑ 4.0 4.1 Makino, Y et al. (1999) Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120. Genes Cells 4 529-39 PubMed GONUTS page
- ↑ Makino, Y et al. (1997) SUG1, a component of the 26 S proteasome, is an ATPase stimulated by specific RNAs. J. Biol. Chem. 272 23201-5 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0090261 ! positive regulation of inclusion body assembly
- GO:1901800 ! positive regulation of proteasomal protein catabolic process
- GO:0045899 ! positive regulation of RNA polymerase II transcription preinitiation complex assembly
- GO:0098794 ! postsynapse
- GO:0036402 ! proteasome-activating activity
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0022624 ! proteasome accessory complex
- GO:0000502 ! proteasome complex
- GO:0008540 ! proteasome regulatory particle, base subcomplex
- GO:0005838 ! proteasome regulatory particle
- GO:0030163 ! protein catabolic process
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