RAT:PLS1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Plscr1
Protein Name(s)	Phospholipid scramblase 1 PL scramblase 1 Ca(2+)-dependent phospholipid scramblase 1
External Links
UniProt	P58195
EMBL	AY024347
RefSeq	NP_476542.1 XP_006243600.1
UniGene	Rn.96807
STRING	10116.ENSRNOP00000053569
PaxDb	P58195
PRIDE	P58195
Ensembl	ENSRNOT00000010689
GeneID	117540
KEGG	rno:117540
UCSC	RGD:620521
CTD	5359
RGD	620521
eggNOG	NOG119855
GeneTree	ENSGT00390000002884
HOGENOM	HOG000237356
HOVERGEN	HBG019157
InParanoid	P58195
OrthoDB	EOG77T14X
NextBio	620353
PRO	PR:P58195
Proteomes	UP000002494
ExpressionAtlas	P58195
Genevestigator	P58195
GO	GO:0005829 GO:0031012 GO:0005794 GO:0005887 GO:0045121 GO:0005730 GO:0005886 GO:0005509 GO:0042609 GO:0003677 GO:0019899 GO:0005154 GO:0017128 GO:0001077 GO:0017124 GO:0006915 GO:0051607 GO:0006955 GO:0045071 GO:0017121 GO:0015914 GO:2000373 GO:0045089 GO:0045944 GO:0060368 GO:0033003
InterPro	IPR005552
PANTHER	PTHR23248
Pfam	PF03803

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005515	protein binding	PMID:23621864^[1]	ECO:0000315			F		Figures 1-4 provide the necessary results	complete CACAO 10600
involved_in	GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	P		Seeded From UniProt	complete
involved_in	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	PMID:18579528^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:18579528^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045089	positive regulation of innate immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	P		Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	P		Seeded From UniProt	complete
enables	GO:0042609	CD4 receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	F		Seeded From UniProt	complete
involved_in	GO:0033003	regulation of mast cell activation	PMID:18579528^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:18579528^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q64725	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:18579528^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07014	F		Seeded From UniProt	complete
enables	GO:0017128	phospholipid scramblase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	F		Seeded From UniProt	complete
involved_in	GO:0017121	plasma membrane phospholipid scrambling	PMID:17712045^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17712045^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18579528^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	F		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15162	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:11259432^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070782	phosphatidylserine exposure on apoptotic cell surface	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:893575 PANTHER:PTN000583059	P		Seeded From UniProt	complete
enables	GO:0017128	phospholipid scramblase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000582979 UniProtKB:O15162 WB:WBGene00011935	F		Seeded From UniProt	complete
involved_in	GO:0017121	plasma membrane phospholipid scrambling	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:893575 PANTHER:PTN000582979 RGD:620521 UniProtKB:O15162 WB:WBGene00011935	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:893575 PANTHER:PTN000583005 RGD:620521 UniProtKB:O15162 UniProtKB:Q9NRQ2	C		Seeded From UniProt	complete
involved_in	GO:0015914	phospholipid transport	PMID:11259432^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0729	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kodigepalli, KM et al. (2013) Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells. Mol. Cancer 12 32 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Amir-Moazami, O et al. (2008) Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway. J. Biol. Chem. 283 25514-23 PubMed GONUTS page
↑ ^3.0 ^3.1 Kantari, C et al. (2007) Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis. Blood 110 4086-95 PubMed GONUTS page
↑ ^4.0 ^4.1 Pastorelli, C et al. (2001) IgE receptor type I-dependent tyrosine phosphorylation of phospholipid scramblase. J. Biol. Chem. 276 20407-12 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23621864-1] Kodigepalli, KM et al. (2013) Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells. Mol. Cancer 12 32 PubMed GONUTS page

[PMID:18579528-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Amir-Moazami, O et al. (2008) Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway. J. Biol. Chem. 283 25514-23 PubMed GONUTS page

[PMID:17712045-3] 3.0 ^3.1 Kantari, C et al. (2007) Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis. Blood 110 4086-95 PubMed GONUTS page

[PMID:11259432-4] 4.0 ^4.1 Pastorelli, C et al. (2001) IgE receptor type I-dependent tyrosine phosphorylation of phospholipid scramblase. J. Biol. Chem. 276 20407-12 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:PLS1

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