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Category:GO:0017128 ! phospholipid scramblase activity
name: phospholipid scramblase activity
namespace: molecular_function
def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]
comment: Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases).
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0140303 ! intramembrane lipid transporter activity
relationship: part_of: GO:0017121 ! plasma membrane phospholipid scrambling
AmiGO
<GOterm>GO:0017128</GOterm>
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