RAT:KCC2D

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Camk2d
Protein Name(s)	Calcium/calmodulin-dependent protein kinase type II subunit delta CaM kinase II subunit delta CaMK-II subunit delta
External Links
UniProt	P15791
EMBL	J05072 BC107562 L13406 L13407 L13408 X77192 X77193 X77194 X77195 X75774
PIR	A34366
RefSeq	NP_036651.1
UniGene	Rn.87208
ProteinModelPortal	P15791
SMR	P15791
BioGrid	246431
IntAct	P15791
MINT	MINT-1892750
STRING	10116.ENSRNOP00000062118
ChEMBL	CHEMBL2111382
PhosphoSite	P15791
PaxDb	P15791
PRIDE	P15791
Ensembl	ENSRNOT00000015564 ENSRNOT00000016026 ENSRNOT00000068198
GeneID	24246
KEGG	rno:24246
CTD	817
RGD	2263
eggNOG	COG0515
GeneTree	ENSGT00760000118944
HOVERGEN	HBG108055
InParanoid	P15791
KO	K04515
OMA	GYTKICD
OrthoDB	EOG7ZD1VM
PhylomeDB	P15791
BRENDA	2.7.11.17
Reactome	REACT_196389 REACT_196391 REACT_196392 REACT_196446 REACT_216105 REACT_258022 REACT_258198
NextBio	602745
Proteomes	UP000002494
ExpressionAtlas	P15791
Genevestigator	P15791
GO	GO:0005737 GO:0005829 GO:0005634 GO:0048471 GO:0043234 GO:0042383 GO:0033017 GO:0005524 GO:0004683 GO:0044325 GO:0050998 GO:0017080 GO:0086003 GO:0061049 GO:0030007 GO:0032469 GO:0018105 GO:0018107 GO:0010613 GO:0070374 GO:0035022 GO:0014911 GO:0048661 GO:0046777 GO:0006468 GO:0098901 GO:0098909 GO:0010881 GO:0010649 GO:1901844 GO:0060341 GO:0010389 GO:1902514 GO:1901897 GO:0010880 GO:2000649 GO:0055119 GO:0001666
InterPro	IPR020636 IPR013543 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24347
Pfam	PF08332 PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004683	calmodulin-dependent protein kinase activity	PMID:22514276^[1]	ECO:0000314			F		Figure 1B. Immunoblot of HEK293 cells expressing Nav1.5 were exposed to rat CAMKIIdC showing phosphorylation of site on loop 1 of sodium channel.	complete CACAO 8126
	GO:0004672	protein kinase activity	PMID:22514276^[1]	ECO:0000315			F		Figure 5: Electrophysiology of channel with mutant phenotype T594A and S516A and also in comparison to drug AIP and WT phenotypes	complete CACAO 8153
	GO:0005954	calcium- and calmodulin-dependent protein kinase complex	PMID:21677263^[2]	ECO:0000314			C		Figure 3: Immunoblot shows CaMKIId forms complex and increases activity of sodium channel	complete CACAO 8167
involved_in	GO:1903076	regulation of protein localization to plasma membrane	PMID:19188609^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P08413,UniProtKB:P11275,UniProtKB:P11730	P	occurs_in:(CL:0002608) has_target_start_location:(GO:0032590) transports_or_maintains_localization_of:(UniProtKB:P06213) has_target_end_location:(GO:0032809)\|occurs_in(CL:0002608) has_target_start_location:(GO:0032590) transports_or_maintains_localization_of:(GO:0017146) has_target_end_location:(GO:0032809)	Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	PMID:23702479^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071277)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:22514276^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:22514276^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010649	regulation of cell communication by electrical coupling	PMID:12676813^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	PMID:12676813^[5]	ECO:0000305	curator inference used in manual assertion	GO:0010649	P		Seeded From UniProt	complete
involved_in	GO:0098909	regulation of cardiac muscle cell action potential involved in regulation of contraction	PMID:12676813^[5]	ECO:0000305	curator inference used in manual assertion	GO:0098901	P		Seeded From UniProt	complete
involved_in	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	PMID:12676813^[5]	ECO:0000305	curator inference used in manual assertion	GO:0010880	P		Seeded From UniProt	complete
involved_in	GO:0098901	regulation of cardiac muscle cell action potential	PMID:12676813^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:12676813^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	PMID:12676813^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:12676813^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002131)\|occurs_in:(GO:0016529)	Seeded From UniProt	complete
involved_in	GO:1901897	regulation of relaxation of cardiac muscle	PMID:23283722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086003	cardiac muscle cell contraction	PMID:12676814^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002082)	Seeded From UniProt	complete
involved_in	GO:0055119	relaxation of cardiac muscle	PMID:12676814^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002082)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:12676814^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E9Q401	F	occurs_in:(UBERON:0002082)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:12676814^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002082) has_direct_input:(UniProtKB:P61014)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:12676814^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002082) has_direct_input:(UniProtKB:E9Q401)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:23283722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:A2ASS6) occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12676814^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12676814^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:12676814^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0002082) has_direct_input:(UniProtKB:P61014)\|occurs_in(UBERON:0002082) has_direct_input:(UniProtKB:E9Q401)	Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:23283722^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:A2ASS6) occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0060341	regulation of cellular localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13557	P		Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13557	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13557	P		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	PMID:17267544^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	PMID:17267544^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:18385282^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061049	cell growth involved in cardiac muscle cell development	PMID:21554860^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050998	nitric-oxide synthase binding	PMID:17293490^[11]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3185	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:18385282^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:17293490^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:11925434^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:18205403^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035022	positive regulation of Rac protein signal transduction	PMID:18385282^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:22360269^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030007	cellular potassium ion homeostasis	PMID:11925434^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014911	positive regulation of smooth muscle cell migration	PMID:18385282^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	PMID:17267544^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:8390994^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9930758^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:11925434^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:11925434^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002389359 WB:WBGene00006779	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341265 PANTHER:PTN002389359 RGD:2263	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88256 PANTHER:PTN002389359 UniProtKB:Q13557 UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264607 MGI:MGI:88256 MGI:MGI:88257 PANTHER:PTN002389359 RGD:2261 RGD:2262 RGD:2263 RGD:621802 UniProtKB:Q13557 UniProtKB:Q9UQM7 WB:WBGene00006779	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039071	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543 InterPro:IPR039071	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR013543	P		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.17	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Ashpole, NM et al. (2012) Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J. Biol. Chem. 287 19856-69 PubMed GONUTS page
↑ Yao, L et al. (2011) Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice. Am. J. Physiol., Cell Physiol. 301 C577-86 PubMed GONUTS page
↑ De Felice, FG et al. (2009) Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc. Natl. Acad. Sci. U.S.A. 106 1971-6 PubMed GONUTS page
↑ Cha, MJ et al. (2013) MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ. Biochem. Biophys. Res. Commun. 435 720-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Maier, LS et al. (2003) Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ. Res. 92 904-11 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Hamdani, N et al. (2013) Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circ. Res. 112 664-74 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Zhang, T et al. (2003) The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ. Res. 92 912-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 House, SJ et al. (2007) Calcium/calmodulin-dependent protein kinase II-delta isoform regulation of vascular smooth muscle cell proliferation. Am. J. Physiol., Cell Physiol. 292 C2276-87 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Mercure, MZ et al. (2008) CaM kinase II delta2-dependent regulation of vascular smooth muscle cell polarization and migration. Am. J. Physiol., Cell Physiol. 294 C1465-75 PubMed GONUTS page
↑ Li, C et al. (2011) The δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway. Biochem. Biophys. Res. Commun. 409 125-30 PubMed GONUTS page
↑ ^11.0 ^11.1 Jones, RJ et al. (2007) iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle. Am. J. Physiol. Heart Circ. Physiol. 292 H2634-42 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Balla, Z et al. (2002) Calcium/calmodulin-dependent protein kinase IIdelta 2 and gamma isoforms regulate potassium currents of rat brain capillary endothelial cells under hypoxic conditions. J. Biol. Chem. 277 21306-14 PubMed GONUTS page
↑ Grueter, CE et al. (2008) Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. Biochemistry 47 1760-7 PubMed GONUTS page
↑ Ginnan, R et al. (2012) MEF2 is regulated by CaMKIIδ2 and a HDAC4-HDAC5 heterodimer in vascular smooth muscle cells. Biochem. J. 444 105-14 PubMed GONUTS page
↑ Schworer, CM et al. (1993) Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta. J. Biol. Chem. 268 14443-9 PubMed GONUTS page
↑ Takeuchi, Y et al. (1999) Nuclear localization of the delta subunit of Ca2+/calmodulin-dependent protein kinase II in rat cerebellar granule cells. J. Neurochem. 72 815-25 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22514276-1] 1.0 ^1.1 ^1.2 ^1.3 Ashpole, NM et al. (2012) Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J. Biol. Chem. 287 19856-69 PubMed GONUTS page

[PMID:21677263-2] Yao, L et al. (2011) Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice. Am. J. Physiol., Cell Physiol. 301 C577-86 PubMed GONUTS page

[PMID:19188609-3] De Felice, FG et al. (2009) Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc. Natl. Acad. Sci. U.S.A. 106 1971-6 PubMed GONUTS page

[PMID:23702479-4] Cha, MJ et al. (2013) MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIδ. Biochem. Biophys. Res. Commun. 435 720-6 PubMed GONUTS page

[PMID:12676813-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Maier, LS et al. (2003) Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ. Res. 92 904-11 PubMed GONUTS page

[PMID:23283722-6] 6.0 ^6.1 ^6.2 Hamdani, N et al. (2013) Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circ. Res. 112 664-74 PubMed GONUTS page

[PMID:12676814-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Zhang, T et al. (2003) The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ. Res. 92 912-9 PubMed GONUTS page

[PMID:17267544-8] 8.0 ^8.1 ^8.2 House, SJ et al. (2007) Calcium/calmodulin-dependent protein kinase II-delta isoform regulation of vascular smooth muscle cell proliferation. Am. J. Physiol., Cell Physiol. 292 C2276-87 PubMed GONUTS page

[PMID:18385282-9] 9.0 ^9.1 ^9.2 ^9.3 Mercure, MZ et al. (2008) CaM kinase II delta2-dependent regulation of vascular smooth muscle cell polarization and migration. Am. J. Physiol., Cell Physiol. 294 C1465-75 PubMed GONUTS page

[PMID:21554860-10] Li, C et al. (2011) The δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway. Biochem. Biophys. Res. Commun. 409 125-30 PubMed GONUTS page

[PMID:17293490-11] 11.0 ^11.1 Jones, RJ et al. (2007) iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle. Am. J. Physiol. Heart Circ. Physiol. 292 H2634-42 PubMed GONUTS page

[PMID:11925434-12] 12.0 ^12.1 ^12.2 ^12.3 Balla, Z et al. (2002) Calcium/calmodulin-dependent protein kinase IIdelta 2 and gamma isoforms regulate potassium currents of rat brain capillary endothelial cells under hypoxic conditions. J. Biol. Chem. 277 21306-14 PubMed GONUTS page

[PMID:18205403-13] Grueter, CE et al. (2008) Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. Biochemistry 47 1760-7 PubMed GONUTS page

[PMID:22360269-14] Ginnan, R et al. (2012) MEF2 is regulated by CaMKIIδ2 and a HDAC4-HDAC5 heterodimer in vascular smooth muscle cells. Biochem. J. 444 105-14 PubMed GONUTS page

[PMID:8390994-15] Schworer, CM et al. (1993) Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta. J. Biol. Chem. 268 14443-9 PubMed GONUTS page

[PMID:9930758-16] Takeuchi, Y et al. (1999) Nuclear localization of the delta subunit of Ca2+/calmodulin-dependent protein kinase II in rat cerebellar granule cells. J. Neurochem. 72 815-25 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:KCC2D

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