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RAT:KAPCA
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Prkaca | |
| Protein Name(s) | cAMP-dependent protein kinase catalytic subunit alpha
PKA C-alpha | |
| External Links | ||
| UniProt | P27791 | |
| EMBL | X57986 AY375243 | |
| PIR | S16240 | |
| UniGene | Rn.20 | |
| ProteinModelPortal | P27791 | |
| SMR | P27791 | |
| IntAct | P27791 | |
| MINT | MINT-4564372 | |
| BindingDB | P27791 | |
| ChEMBL | CHEMBL3390 | |
| PhosphoSite | P27791 | |
| PaxDb | P27791 | |
| PRIDE | P27791 | |
| RGD | 3389 | |
| eggNOG | COG0515 | |
| HOGENOM | HOG000233033 | |
| HOVERGEN | HBG108317 | |
| InParanoid | P27791 | |
| PhylomeDB | P27791 | |
| BRENDA | 2.7.11.11 | |
| Reactome | REACT_217998 REACT_231505 REACT_236244 REACT_236319 REACT_257138 | |
| Proteomes | UP000002494 | |
| Genevestigator | P27791 | |
| GO | GO:0005952 GO:0005737 GO:0005829 GO:0005794 GO:0016020 GO:0005739 GO:0031514 GO:0043005 GO:0005654 GO:0005634 GO:0048471 GO:0005886 GO:0043234 GO:0097225 GO:0005524 GO:0004691 GO:0032403 GO:0034237 GO:0019901 GO:0017137 GO:0051447 GO:0018105 GO:0006468 GO:0043457 GO:0051966 | |
| InterPro | IPR000961 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 | |
| Pfam | PF00069 | |
| SMART | SM00133 SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS51285 PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004691 |
cAMP-dependent protein kinase activity |
ECO:0000314 |
F |
Figure 3 clearly shows that the addition of the direct cAMP activator increases the effects on the protein kinase A as compared to the control. |
complete | |||||
|
part_of |
GO:0036126 |
sperm flagellum |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001669 |
acrosomal vesicle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034605 |
cellular response to heat |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017137 |
Rab GTPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051966 |
regulation of synaptic transmission, glutamatergic |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051447 |
negative regulation of meiotic cell cycle |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:2741 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043457 |
regulation of cellular respiration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043005 |
neuron projection |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042747 |
circadian sleep/wake cycle, REM sleep |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034237 |
protein kinase A regulatory subunit binding |
ECO:0000305 |
curator inference used in manual assertion |
GO:0004691 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005952 |
cAMP-dependent protein kinase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005952 |
cAMP-dependent protein kinase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004691 |
cAMP-dependent protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004691 |
cAMP-dependent protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004691 |
cAMP-dependent protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004691 |
cAMP-dependent protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010737 |
protein kinase A signaling |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034237 |
protein kinase A regulatory subunit binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071333 |
cellular response to glucose stimulus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004691 |
cAMP-dependent protein kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097225 |
sperm midpiece |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-RNO-379836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-RNO-379836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004691 |
cAMP-dependent protein kinase activity |
Reactome:R-RNO-164341 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031514 |
motile cilium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005929 |
cilium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001669 |
acrosomal vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Adams, AC & Keefe, KA (2001) Examination of the involvement of protein kinase A in D2 dopamine receptor antagonist-induced immediate early gene expression. J. Neurochem. 77 326-35 PubMed GONUTS page
- ↑ Fang, X et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. U.S.A. 97 11960-5 PubMed GONUTS page
- ↑ Su, W & Liu, X (2013) RAB13 regulates Sertoli cell permeability barrier dynamics through protein kinase A. J. Mol. Endocrinol. 50 305-18 PubMed GONUTS page
- ↑ 4.0 4.1 Shao, XM et al. (2003) Modulation of AMPA receptors by cAMP-dependent protein kinase in preBötzinger complex inspiratory neurons regulates respiratory rhythm in the rat. J. Physiol. (Lond.) 547 543-53 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Kovo, M et al. (2006) An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes. Reproduction 132 33-43 PubMed GONUTS page
- ↑ 6.0 6.1 Manni, S et al. (2008) Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells. J. Biol. Chem. 283 24145-54 PubMed GONUTS page
- ↑ 7.0 7.1 Widén, C et al. (2003) Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells. Biochem. J. 373 211-20 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Yao, L et al. (2003) Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-beta gamma dimers. Proc. Natl. Acad. Sci. U.S.A. 100 14379-84 PubMed GONUTS page
- ↑ Datta, S & Desarnaud, F (2010) Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep. J. Neurosci. 30 12263-73 PubMed GONUTS page
- ↑ 10.0 10.1 Obara, Y et al. (2004) PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. J. Cell. Sci. 117 6085-94 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Yao, L et al. (2002) betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell 109 733-43 PubMed GONUTS page
- ↑ Han, Y et al. (2013) Regulation of cyclin D2 expression and degradation by follicle-stimulating hormone during rat granulosa cell proliferation in vitro. Biol. Reprod. 88 57 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Dwivedi, Y et al. (2002) Differential effects of haloperidol and clozapine on [(3)H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. J. Pharmacol. Exp. Ther. 301 197-209 PubMed GONUTS page
c
- GO:0004691 ! cAMP-dependent protein kinase activity
- GO:0005952 ! cAMP-dependent protein kinase complex
- GO:0034605 ! cellular response to heat
- GO:0071333 ! cellular response to glucose stimulus
- GO:0042995 ! cell projection
- Chordata
- GO:0005929 ! cilium
- GO:0042747 ! circadian sleep/wake cycle, REM sleep
- Craniata
- GO:0005737 ! cytoplasm
- GO:0031410 ! cytoplasmic vesicle
- GO:0005829 ! cytosol
m
n
p
- GO:0018105 ! peptidyl-serine phosphorylation
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0032991 ! protein-containing complex
- GO:0044877 ! protein-containing complex binding
- GO:0034237 ! protein kinase A regulatory subunit binding
- GO:0019901 ! protein kinase binding
- GO:0010737 ! protein kinase A signaling
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
r
