RAT:GRID2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Grid2
Protein Name(s)	Glutamate receptor ionotropic, delta-2 GluD2 GluR delta-2 subunit
External Links
UniProt	Q63226
EMBL	Z17239 U08256
PIR	S28858
RefSeq	NP_077355.1
UniGene	Rn.10046
PDB	2V3T 2V3U
PDBsum	2V3T 2V3U
ProteinModelPortal	Q63226
SMR	Q63226
DIP	DIP-40709N
IntAct	Q63226
MINT	MINT-350054
GuidetoPHARMACOLOGY	449
PhosphoSite	Q63226
PaxDb	Q63226
GeneID	79220
KEGG	rno:79220
UCSC	RGD:68368
CTD	2895
RGD	68368
eggNOG	NOG276334
HOGENOM	HOG000264260
HOVERGEN	HBG051840
InParanoid	Q63226
KO	K05207
PhylomeDB	Q63226
TreeFam	TF352434
EvolutionaryTrace	Q63226
NextBio	614640
PRO	PR:Q63226
Proteomes	UP000002494
Genevestigator	Q63226
GO	GO:0030054 GO:0030425 GO:0008328 GO:0014069 GO:0045211 GO:0005234 GO:0004970 GO:0030165 GO:0034613 GO:0021707 GO:0007157 GO:0034220 GO:0035235 GO:0035249
InterPro	IPR001828 IPR019594 IPR001508 IPR001320 IPR028082
Pfam	PF01094 PF00060
PRINTS	PR00177
SMART	SM00918 SM00079
SUPFAM	SSF53822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0034613	cellular protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61625	P		Seeded From UniProt	complete
involved_in	GO:0021707	cerebellar granule cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61625	P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61625	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:12589829^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88382	F		Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:21410790^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:20395510^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:20395510^[3]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:20395510^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:21410790^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:20395510^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:20395510^[3]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:8987804^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:8987804^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098688)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21410790^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20395510^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20395510^[3]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:8987804^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20395510^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21410790^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20395510^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:20395510^[3]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098688	parallel fiber to Purkinje cell synapse	PMID:8987804^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:8987804^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:16198122^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008150	biological_process	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95815 PANTHER:PTN001826301	F		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001826301 UniProtKB:Q13002	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0020429 MGI:MGI:95813 MGI:MGI:95815 MGI:MGI:95817 MGI:MGI:95818 PANTHER:PTN001826301 RGD:68366 RGD:68368	C		Seeded From UniProt	complete
involved_in	GO:0035249	synaptic transmission, glutamatergic	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0020429 FB:FBgn0039916 MGI:MGI:95813 MGI:MGI:95814 MGI:MGI:95815 MGI:MGI:95818 PANTHER:PTN001826301	P		Seeded From UniProt	complete
enables	GO:0008066	glutamate receptor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 PANTHER:PTN001826301 RGD:2733 RGD:2735 RGD:71027	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0052704 MGI:MGI:95808 MGI:MGI:95813 MGI:MGI:95816 PANTHER:PTN000437926 RGD:621531 TAIR:locus:2207165 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q16478 WB:WBGene00001612	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19617541^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q63226	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17715062^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q63226	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005216	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004970	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1904315	P		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR019594	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR001508 InterPro:IPR019594	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yap, CC et al. (2003) PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. Biochem. Biophys. Res. Commun. 301 1122-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Matsuda, K & Yuzaki, M (2011) Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur. J. Neurosci. 33 1447-61 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Matsuda, K et al. (2010) Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. Science 328 363-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Landsend, AS et al. (1997) Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses. J. Neurosci. 17 834-42 PubMed GONUTS page
↑ Gounko, NV et al. (2005) CRF and urocortin differentially modulate GluRdelta2 expression and distribution in parallel fiber-Purkinje cell synapses. Mol. Cell. Neurosci. 30 513-22 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Chaudhry, C et al. (2009) Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions. Proc. Natl. Acad. Sci. U.S.A. 106 12329-34 PubMed GONUTS page
↑ Naur, P et al. (2007) Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proc. Natl. Acad. Sci. U.S.A. 104 14116-21 PubMed GONUTS page

[PMID:12589829-1] Yap, CC et al. (2003) PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. Biochem. Biophys. Res. Commun. 301 1122-8 PubMed GONUTS page

[PMID:21410790-2] 2.0 ^2.1 ^2.2 ^2.3 Matsuda, K & Yuzaki, M (2011) Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur. J. Neurosci. 33 1447-61 PubMed GONUTS page

[PMID:20395510-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Matsuda, K et al. (2010) Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. Science 328 363-8 PubMed GONUTS page

[PMID:8987804-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Landsend, AS et al. (1997) Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses. J. Neurosci. 17 834-42 PubMed GONUTS page

[PMID:16198122-5] Gounko, NV et al. (2005) CRF and urocortin differentially modulate GluRdelta2 expression and distribution in parallel fiber-Purkinje cell synapses. Mol. Cell. Neurosci. 30 513-22 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19617541-7] Chaudhry, C et al. (2009) Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions. Proc. Natl. Acad. Sci. U.S.A. 106 12329-34 PubMed GONUTS page

[PMID:17715062-8] Naur, P et al. (2007) Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proc. Natl. Acad. Sci. U.S.A. 104 14116-21 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

RAT:GRID2

Contents

Annotations

Notes

References

b

c

e

g

h

i

m

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools