RAT:GLRA1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Glra1 (synonyms: Glyr)
Protein Name(s)	Glycine receptor subunit alpha-1 Glycine receptor 48 kDa subunit Glycine receptor strychnine-binding subunit
External Links
UniProt	P07727
EMBL	D00833 X55246 M63915 AJ310835 Y00276
PIR	JN0014 S20662
RefSeq	NP_037265.1 XP_006246440.1
UniGene	Rn.10109
ProteinModelPortal	P07727
SMR	P07727
DIP	DIP-48879N
BindingDB	P07727
ChEMBL	CHEMBL3246
iPTMnet	P07727
Ensembl	ENSRNOT00000063889
GeneID	25674
KEGG	rno:25674
UCSC	RGD:2704
CTD	2741
RGD	2704
HOGENOM	HOG000231336
HOVERGEN	HBG051707
InParanoid	P07727
KO	K05193
PhylomeDB	P07727
NextBio	607619
PRO	PR:P07727
Proteomes	UP000002494
ExpressionAtlas	P07727
GO	GO:0030054 GO:0034707 GO:0005783 GO:0009897 GO:0060077 GO:0005887 GO:0043231 GO:0016020 GO:0043005 GO:0043025 GO:0045211 GO:0045202 GO:0016934 GO:0016933 GO:0016594 GO:0030977 GO:0022824 GO:0008270 GO:0007340 GO:0001508 GO:0007628 GO:0006820 GO:0071230 GO:0071361 GO:0071294 GO:1902476 GO:0006821 GO:0060080 GO:0034220 GO:0006811 GO:0006936 GO:0051970 GO:0050884 GO:0007218 GO:2000344 GO:0051291 GO:0051260 GO:0002087 GO:0097305 GO:0043200 GO:0060013 GO:0001964 GO:0060012 GO:0007601
Gene3D	2.70.170.10
InterPro	IPR006028 IPR008127 IPR008128 IPR006202 IPR006201 IPR006029 IPR018000
PANTHER	PTHR18945
Pfam	PF02931 PF02932
PRINTS	PR00253 PR01673 PR01674 PR00252
SUPFAM	SSF63712 SSF90112
TIGRFAMs	TIGR00860
PROSITE	PS00236

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060080	response to alcohol	PMID:27058626^[1]	ECO:0000250		PMID:27058626^[1] UniProtKB:P07727	P		The graphical display figure in the paper describes and explains the effect of glycine in rat's brains. The figure is also indirectly an info-graphic that helps in understanding the protein's function. Glycine receptors are ligand gated chloride channels that are found in a rat's brain. In this investigation, the researchers investigated the inhibitory potential of glycine against alcohol-induced oxidative stress, neuroinflammation and neurodegeneration in the rat brain. The researchers performed Gly co-treatment on the rat pups to investigate it's effects by injecting ethanol into the rat brains. They found that glycine reduced the alcohol induced stress and neuronal loss in the rat brain. Therefore with this finding, they concluded that glycine could be a potential treatment against alcohol-intoxication for newborns and infants.	complete CACAO 11575
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64018	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64018	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64018	C		Seeded From UniProt	complete
involved_in	GO:0097305	response to alcohol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64018	P		Seeded From UniProt	complete
involved_in	GO:0060080	inhibitory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64018	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	F		Seeded From UniProt	complete
involved_in	GO:0071361	cellular response to ethanol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	P		Seeded From UniProt	complete
involved_in	GO:0071294	cellular response to zinc ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	P		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	P		Seeded From UniProt	complete
involved_in	GO:0051970	negative regulation of transmission of nerve impulse	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	C		Seeded From UniProt	complete
enables	GO:0030977	taurine binding	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	F		Seeded From UniProt	complete
enables	GO:0016934	extracellularly glycine-gated chloride channel activity	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	F		Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	P		Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	P		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	P		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	C		Seeded From UniProt	complete
involved_in	GO:0001964	startle response	PMID:2155780^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23415	P		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	PMID:25339867^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098690) part_of:(UBERON:0000988)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:23175852^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0044305)	Seeded From UniProt	complete
part_of	GO:0098690	glycinergic synapse	PMID:25339867^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000988)	Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:23175852^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060012	synaptic transmission, glycinergic	PMID:15574743^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	PMID:15574743^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:14749434^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016934	extracellularly glycine-gated chloride channel activity	PMID:12223345^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016933	extracellularly glycine-gated ion channel activity	PMID:15574743^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	PMID:15574743^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	PMID:1703526^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006820	anion transport	PMID:12223345^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039840 MGI:MGI:95750 PANTHER:PTN001055382 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P48167 WB:WBGene00001591 WB:WBGene00001592	P		Seeded From UniProt	complete
involved_in	GO:0060012	synaptic transmission, glycinergic	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 MGI:MGI:95751 PANTHER:PTN001055303 RGD:2704 RGD:2706	P		Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87888 PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P43681	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000435685	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 UniProtKB:G5EDF1 UniProtKB:P11230 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95750 PANTHER:PTN001055303 ZFIN:ZDB-GENE-010410-3 ZFIN:ZDB-GENE-991117-1	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 PANTHER:PTN000434994 RGD:2351 RGD:621544 WB:WBGene00000042 WB:WBGene00002974 WB:WBGene00006765 WB:WBGene00006774	C		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87885 MGI:MGI:87887 MGI:MGI:87888 MGI:MGI:87890 MGI:MGI:87891 MGI:MGI:87892 MGI:MGI:87893 MGI:MGI:87894 MGI:MGI:87895 MGI:MGI:95747 MGI:MGI:95751 MGI:MGI:99779 PANTHER:PTN000434994 RGD:2348 UniProtKB:P02708 UniProtKB:P23415	P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95613 PANTHER:PTN000434994 UniProtKB:P23416 UniProtKB:P36544 UniProtKB:Q401N2 WB:WBGene00000055 WB:WBGene00002974 WB:WBGene00006797	P		Seeded From UniProt	complete
contributes_to	GO:0016934	extracellularly glycine-gated chloride channel activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 MGI:MGI:95750 MGI:MGI:95751 PANTHER:PTN001055303 RGD:2704 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P48167 ZFIN:ZDB-GENE-040801-106	F		Seeded From UniProt	complete
contributes_to	GO:0016594	glycine binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95747 MGI:MGI:95751 PANTHER:PTN001055303 RGD:2704 RGD:2706 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P48167	F		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003011 FB:FBgn0086778 MGI:MGI:103156 MGI:MGI:95613 MGI:MGI:95623 MGI:MGI:95747 PANTHER:PTN000434994 RGD:2648 RGD:61859 RGD:61901 UniProtKB:P48167 WB:WBGene00000050 WB:WBGene00000054	P		Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001055303 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P48167	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 UniProtKB:P11230 UniProtKB:P17787 UniProtKB:P30926 UniProtKB:P32297 UniProtKB:P36544 UniProtKB:P43681 UniProtKB:Q15822	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1861899 MGI:MGI:95623 MGI:MGI:95750 PANTHER:PTN000434994 RGD:2649 RGD:2650 RGD:61855 RGD:61861 RGD:621229 UniProtKB:O75311 UniProtKB:P23415 UniProtKB:P23416 UniProtKB:P28472 UniProtKB:P48167 UniProtKB:Q9UGM1 WB:WBGene00000955 WB:WBGene00001133 WB:WBGene00001591 WB:WBGene00001592	C		Seeded From UniProt	complete
contributes_to	GO:0005254	chloride channel activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001055382 WB:WBGene00003386 WB:WBGene00013746	F		Seeded From UniProt	complete
contributes_to	GO:0005230	extracellular ligand-gated ion channel activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000434994 WB:WBGene00000043 WB:WBGene00001512 WB:WBGene00003386 WB:WBGene00006774 WB:WBGene00012857 WB:WBGene00017375	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:17145751^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17145751^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17145751^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016934	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016934	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016934	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016934	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016934	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016933	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016934	P		Seeded From UniProt	complete
involved_in	GO:2000344	positive regulation of acrosome reaction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
involved_in	GO:0071361	cellular response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
involved_in	GO:0071294	cellular response to zinc ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
involved_in	GO:0051970	negative regulation of transmission of nerve impulse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	C		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
enables	GO:0030977	taurine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	F		Seeded From UniProt	complete
enables	GO:0016934	extracellularly glycine-gated chloride channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	F		Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	C		Seeded From UniProt	complete
involved_in	GO:0001964	startle response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23415 ensembl:ENSP00000411593	P		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	F		Seeded From UniProt	complete
part_of	GO:0098690	glycinergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	C		Seeded From UniProt	complete
involved_in	GO:0097305	response to alcohol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0060080	inhibitory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
part_of	GO:0060077	inhibitory synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	C		Seeded From UniProt	complete
involved_in	GO:0060013	righting reflex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0060012	synaptic transmission, glycinergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0050905	neuromuscular process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0050884	neuromuscular process controlling posture	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	C		Seeded From UniProt	complete
involved_in	GO:0043576	regulation of respiratory gaseous exchange	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	C		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
enables	GO:0016934	extracellularly glycine-gated chloride channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	C		Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0007340	acrosome reaction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0002087	regulation of respiratory gaseous exchange by neurological system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0001964	startle response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
involved_in	GO:0001508	action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64018 ensembl:ENSMUSP00000075032	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006028 InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006028 InterPro:IPR006201	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006202 InterPro:IPR036734	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008127	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006029 InterPro:IPR006202 InterPro:IPR036719 InterPro:IPR036734	P		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008128	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006028 InterPro:IPR006029 InterPro:IPR006201 InterPro:IPR006202 InterPro:IPR008128 InterPro:IPR036719 InterPro:IPR036734	C		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008127	F		Seeded From UniProt	complete
enables	GO:0016934	extracellularly glycine-gated chloride channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008128	F		Seeded From UniProt	complete
enables	GO:0022824	transmitter-gated ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008127	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006028 InterPro:IPR006201	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008128	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0034707	chloride channel complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Amin, FU et al. (2016) Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. Neurochem. Int. PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Grenningloh, G et al. (1990) Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 9 771-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Trojanova, J et al. (2014) Distribution of glycine receptors on the surface of the mature calyx of Held nerve terminal. Front Neural Circuits 8 120 PubMed GONUTS page
↑ ^4.0 ^4.1 Hruskova, B et al. (2012) Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse. J. Neurosci. 32 17012-24 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Burzomato, V et al. (2004) Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens. J. Neurosci. 24 10924-40 PubMed GONUTS page
↑ Beato, M et al. (2004) The activation mechanism of alpha1 homomeric glycine receptors. J. Neurosci. 24 895-906 PubMed GONUTS page
↑ ^7.0 ^7.1 Froh, M et al. (2002) Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 283 G856-63 PubMed GONUTS page
↑ Malosio, ML et al. (1991) Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor. J. Biol. Chem. 266 2048-53 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 ^9.14 ^9.15 ^9.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Oertel, J et al. (2007) A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes. J. Biol. Chem. 282 2798-807 PubMed GONUTS page

[PMID:27058626-1] 1.0 ^1.1 Amin, FU et al. (2016) Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. Neurochem. Int. PubMed GONUTS page

[PMID:2155780-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Grenningloh, G et al. (1990) Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 9 771-6 PubMed GONUTS page

[PMID:25339867-3] 3.0 ^3.1 Trojanova, J et al. (2014) Distribution of glycine receptors on the surface of the mature calyx of Held nerve terminal. Front Neural Circuits 8 120 PubMed GONUTS page

[PMID:23175852-4] 4.0 ^4.1 Hruskova, B et al. (2012) Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse. J. Neurosci. 32 17012-24 PubMed GONUTS page

[PMID:15574743-5] 5.0 ^5.1 ^5.2 ^5.3 Burzomato, V et al. (2004) Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens. J. Neurosci. 24 10924-40 PubMed GONUTS page

[PMID:14749434-6] Beato, M et al. (2004) The activation mechanism of alpha1 homomeric glycine receptors. J. Neurosci. 24 895-906 PubMed GONUTS page

[PMID:12223345-7] 7.0 ^7.1 Froh, M et al. (2002) Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 283 G856-63 PubMed GONUTS page

[PMID:1703526-8] Malosio, ML et al. (1991) Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor. J. Biol. Chem. 266 2048-53 PubMed GONUTS page

[PMID:21873635-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 ^9.14 ^9.15 ^9.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17145751-10] 10.0 ^10.1 ^10.2 Oertel, J et al. (2007) A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes. J. Biol. Chem. 282 2798-807 PubMed GONUTS page

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