RAT:FGF2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Fgf2 (synonyms: Fgf-2)
Protein Name(s)	Fibroblast growth factor 2 FGF-2 Basic fibroblast growth factor bFGF Heparin-binding growth factor 2 HBGF-2
External Links
UniProt	P13109
EMBL	M22427 X07285 U78079 X61697
PIR	A31674
RefSeq	NP_062178.1
UniGene	Rn.31808
ProteinModelPortal	P13109
SMR	P13109
BioGrid	248473
PhosphoSite	P13109
PaxDb	P13109
Ensembl	ENSRNOT00000023388
GeneID	54250
KEGG	rno:54250
UCSC	RGD:2609
CTD	2247
RGD	2609
eggNOG	NOG325757
GeneTree	ENSGT00730000110923
HOGENOM	HOG000236341
HOVERGEN	HBG007580
InParanoid	P13109
KO	K18497
OMA	LPMSAKC
OrthoDB	EOG7992S1
PhylomeDB	P13109
TreeFam	TF317805
Reactome	REACT_198300 REACT_198665 REACT_198729 REACT_198756 REACT_198798 REACT_198804 REACT_198810 REACT_198813 REACT_198995 REACT_202034 REACT_212185 REACT_235451 REACT_240421 REACT_244272 REACT_252685 REACT_255209 REACT_256279 REACT_256376 REACT_257653 REACT_262505 REACT_79133
NextBio	610748
PRO	PR:P13109
Proteomes	UP000002494
ExpressionAtlas	P13109
Genevestigator	P13109
GO	GO:0005737 GO:0005829 GO:0005615 GO:0005634 GO:0005104 GO:0008201 GO:0000186 GO:0007568 GO:0060978 GO:0001658 GO:0060128 GO:0009792 GO:0008543 GO:0010001 GO:0030324 GO:0060644 GO:0060548 GO:0008285 GO:0001759 GO:0045766 GO:0090263 GO:0060045 GO:0051781 GO:0008284 GO:0021940 GO:0010595 GO:0001938 GO:0070374 GO:0045669 GO:0051897 GO:0048661 GO:0045944 GO:0051726 GO:0046668 GO:0048678 GO:0048864 GO:0021762 GO:0060129 GO:0042060
InterPro	IPR008996 IPR028223 IPR002209 IPR028142
PANTHER	PTHR11486 PTHR11486:SF68
PRINTS	PR00263 PR00262
SMART	SM00442
SUPFAM	SSF50353
PROSITE	PS00247

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0038001	paracrine signaling	PMID:28679962^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_start_location:(CL:0002548) has_end_location:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09038	F		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:19952283^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	PMID:11397779^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:8603495^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:9854551^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:12533868^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:19476451^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:12000311^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:9356923^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7508717^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7508717^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:10766846^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q498D6	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:10766846^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:10766846^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35758	P		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	PMID:10766846^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q498D6	F		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	PMID:10766846^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21803	F		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	PMID:10766846^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35758	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0048864	stem cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0046668	regulation of retinal cell programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0021762	substantia nigra development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0010001	glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	C		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0060644	mammary gland epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0060128	corticotropin hormone secreting cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15655 ensembl:ENSMUSP00000143094	P		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028223	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028223	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002209	F		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028223	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Shimizu, T et al. (2017) Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. JCI Insight 2 PubMed GONUTS page
↑ Owczarek, S et al. (2010) Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor. FASEB J. 24 1139-50 PubMed GONUTS page
↑ Tomanek, RJ et al. (2001) Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis. Circ. Res. 88 1135-41 PubMed GONUTS page
↑ Pasumarthi, KB et al. (1996) High and low molecular weight fibroblast growth factor-2 increase proliferation of neonatal rat cardiac myocytes but have differential effects on binucleation and nuclear morphology. Evidence for both paracrine and intracrine actions of fibroblast growth factor-2. Circ. Res. 78 126-36 PubMed GONUTS page
↑ Randone, B et al. (1998) Suppression of smooth muscle cell proliferation after experimental PTFE arterial grafting: a role for polyclonal anti-basic fibroblast growth factor (bFGF) antibody. Eur J Vasc Endovasc Surg 16 401-7 PubMed GONUTS page
↑ Wang, HJ et al. (2001) [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]. Fa Yi Xue Za Zhi 17 198-201, 204 PubMed GONUTS page
↑ Unur, E et al. (2009) Effect of anti-basic fibroblast growth factor (anti-bFGF) on in vitro embryonic development in rat. Anat Histol Embryol 38 241-5 PubMed GONUTS page
↑ Delehedde, M et al. (2002) Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts. Biochem. J. 366 235-44 PubMed GONUTS page
↑ Bugra, K & Hicks, D (1997) Acidic and basic fibroblast growth factor messenger RNA and protein show increased expression in adult compared to developing normal and dystrophic rat retina. J. Mol. Neurosci. 9 13-25 PubMed GONUTS page
↑ ^10.0 ^10.1 Eckenstein, FP et al. (1994) Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors. Biochem. Pharmacol. 47 103-10 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Konishi, M et al. (2000) Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. J. Biol. Chem. 275 12119-22 PubMed GONUTS page

[PMID:28679962-1] Shimizu, T et al. (2017) Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. JCI Insight 2 PubMed GONUTS page

[PMID:19952283-2] Owczarek, S et al. (2010) Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor. FASEB J. 24 1139-50 PubMed GONUTS page

[PMID:11397779-3] Tomanek, RJ et al. (2001) Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis. Circ. Res. 88 1135-41 PubMed GONUTS page

[PMID:8603495-4] Pasumarthi, KB et al. (1996) High and low molecular weight fibroblast growth factor-2 increase proliferation of neonatal rat cardiac myocytes but have differential effects on binucleation and nuclear morphology. Evidence for both paracrine and intracrine actions of fibroblast growth factor-2. Circ. Res. 78 126-36 PubMed GONUTS page

[PMID:9854551-5] Randone, B et al. (1998) Suppression of smooth muscle cell proliferation after experimental PTFE arterial grafting: a role for polyclonal anti-basic fibroblast growth factor (bFGF) antibody. Eur J Vasc Endovasc Surg 16 401-7 PubMed GONUTS page

[PMID:12533868-6] Wang, HJ et al. (2001) [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]. Fa Yi Xue Za Zhi 17 198-201, 204 PubMed GONUTS page

[PMID:19476451-7] Unur, E et al. (2009) Effect of anti-basic fibroblast growth factor (anti-bFGF) on in vitro embryonic development in rat. Anat Histol Embryol 38 241-5 PubMed GONUTS page

[PMID:12000311-8] Delehedde, M et al. (2002) Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts. Biochem. J. 366 235-44 PubMed GONUTS page

[PMID:9356923-9] Bugra, K & Hicks, D (1997) Acidic and basic fibroblast growth factor messenger RNA and protein show increased expression in adult compared to developing normal and dystrophic rat retina. J. Mol. Neurosci. 9 13-25 PubMed GONUTS page

[PMID:7508717-10] 10.0 ^10.1 Eckenstein, FP et al. (1994) Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors. Biochem. Pharmacol. 47 103-10 PubMed GONUTS page

[PMID:10766846-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Konishi, M et al. (2000) Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. J. Biol. Chem. 275 12119-22 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

RAT:FGF2

Contents

Annotations

Notes

References

a

b

c

e

f

g

h

i

l

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools