PMID:7508717

Citation	Eckenstein, FP, Kuzis, K, Nishi, R, Woodward, WR, Meshul, C, Sherman, L and Ciment, G (1994) Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors. Biochem. Pharmacol. 47:103-10
Abstract	The distribution in the rat nervous system of acidic and basic fibroblast growth factors (FGFs) was analysed by a combination of biochemical and anatomical methods. Acidic FGF (aFGF) was found to be present exclusively in specific neuronal populations, such as motor neurons and basal forebrain cholinergic neurons. Basic FGF (bFGF) was found in astrocytes and in neurons in hippocampal area CA2. Within labelled astrocytes and CA2-neurons, bFGF was detected in both the cytoplasm and the nucleus. The levels of intracellular bFGF were manipulated by antisense oligonucleotide treatment of cultures of developing neural crest cells. Results indicated that the amount of melanogenesis in the cultures is likely to be regulated by intracellular, possibly nuclear bFGF.
Links	PubMed
Keywords	Animals; Cell Nucleus/metabolism; Cerebral Cortex/metabolism; Cerebral Cortex/ultrastructure; Cytoplasm/metabolism; Fibroblast Growth Factor 1/metabolism; Fibroblast Growth Factor 1/physiology; Fibroblast Growth Factor 2/metabolism; Fibroblast Growth Factor 2/physiology; Hippocampus/metabolism; Hippocampus/ultrastructure; Immunoenzyme Techniques; Melanocytes/metabolism; Neurons/metabolism; Neurons/ultrastructure; Oligonucleotides, Antisense; Peripheral Nerves/metabolism; Peripheral Nerves/ultrastructure; Rats
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:FGF2	part_of	GO:0005737: cytoplasm	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
RAT:FGF2	part_of	GO:0005634: nucleus	ECO:0000314: direct assay evidence used in manual assertion		C		Seeded From UniProt	complete

References

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