RAT:CXA1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Gja1 (synonyms: Cxn-43)
Protein Name(s)	Gap junction alpha-1 protein Connexin-43 Cx43 Gap junction 43 kDa heart protein
External Links
UniProt	P08050
EMBL	X06656 AY324140 BC081842
PIR	A24047 S00532
RefSeq	NP_036699.1 XP_006256565.1
UniGene	Rn.10346
PDB	1R5S 3CYY
PDBsum	1R5S 3CYY
DisProt	DP00278
ProteinModelPortal	P08050
SMR	P08050
BioGrid	246562
DIP	DIP-34793N
IntAct	P08050
MINT	MINT-1791096
TCDB	1.A.24.1.1
PhosphoSite	P08050
PaxDb	P08050
PRIDE	P08050
Ensembl	ENSRNOT00000001054
GeneID	24392
KEGG	rno:24392
UCSC	RGD:2690
CTD	2697
RGD	2690
eggNOG	NOG45368
GeneTree	ENSGT00760000118780
HOGENOM	HOG000231127
HOVERGEN	HBG009576
InParanoid	P08050
KO	K07372
OMA	GANVDMH
OrthoDB	EOG7P2XSS
PhylomeDB	P08050
TreeFam	TF329606
Reactome	REACT_238817 REACT_243437 REACT_243745 REACT_250352 REACT_250661 REACT_250855 REACT_250889
EvolutionaryTrace	P08050
NextBio	603181
PRO	PR:P08050
Proteomes	UP000002494
ExpressionAtlas	P08050
Genevestigator	P08050
GO	GO:0016324 GO:0005922 GO:0043292 GO:0005737 GO:0005829 GO:0005769 GO:0005789 GO:0005768 GO:0070062 GO:0005916 GO:0005921 GO:0005794 GO:0000139 GO:0030660 GO:0005887 GO:0005882 GO:0005770 GO:0016328 GO:0005764 GO:0016020 GO:0045121 GO:0005741 GO:0005771 GO:0005886 GO:0071253 GO:0005243 GO:0030165 GO:0019904 GO:0017124 GO:0004871 GO:0007512 GO:0006915 GO:0015867 GO:0003294 GO:0048514 GO:0061337 GO:0007154 GO:0010643 GO:0010644 GO:0007267 GO:0071260 GO:0002544 GO:0042733 GO:0003158 GO:0002070 GO:0016264 GO:0007507 GO:0001947 GO:0001701 GO:0002088 GO:0060156 GO:0060044 GO:0008285 GO:2000279 GO:0001937 GO:0010629 GO:0061045 GO:0001764 GO:0048812 GO:0001649 GO:2000987 GO:0010652 GO:0007204 GO:0010628 GO:0003104 GO:0043123 GO:0032024 GO:0045732 GO:0045844 GO:0045907 GO:0045909 GO:0051259 GO:0060371 GO:0030500 GO:0046850 GO:0051924 GO:2000810 GO:0060373 GO:0060307 GO:0034405 GO:0009749 GO:0043434 GO:0009268 GO:0043403 GO:0055085 GO:0010232
InterPro	IPR000500 IPR002261 IPR013124 IPR019570 IPR017990 IPR013092
PANTHER	PTHR11984
Pfam	PF00029 PF03508 PF10582
PRINTS	PR00206 PR01132
SMART	SM00037 SM01089
PROSITE	PS00407 PS00408

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005243	gap junction channel activity	PMID:2826492^[1]	ECO:0000314			F		Figure 1 shows a northern blot analysis of a rat liver gap junction and a rat heart gap junction.	complete CACAO 9460
involved_in	GO:0007283	spermatogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	C		Seeded From UniProt	complete
enables	GO:0055077	gap junction hemi-channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17302	F		Seeded From UniProt	complete
involved_in	GO:0099111	microtubule-based transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17302-5	P		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:27626200^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	P		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:14699011^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00523	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:14699011^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P39447	F		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	PMID:19808665^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	PMID:19808665^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28234	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15492000^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:15492000^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P39447	F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:15492000^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00523	F		Seeded From UniProt	complete
involved_in	GO:0022898	regulation of transmembrane transporter activity	PMID:15284189^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	PMID:15284189^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	PMID:15284189^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:15284189^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:15181016^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23242	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:18162583^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17673670^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:0002131)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18162583^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:18162583^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:15709751^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000987	positive regulation of behavioral fear response	PMID:22665389^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000810	regulation of bicellular tight junction assembly	PMID:19509333^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	PMID:14702389^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905867	epididymis development	PMID:12388089^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	PMID:15301736^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071374	cellular response to parathyroid hormone stimulus	PMID:11159864^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:10631100^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071253	connexin binding	PMID:11557558^[18]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2692	F		Seeded From UniProt	complete
involved_in	GO:0061045	negative regulation of wound healing	PMID:18172080^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060044	negative regulation of cardiac muscle cell proliferation	PMID:19377854^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	PMID:24503060^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	PMID:16878174^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:15817491^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:11557558^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:16731531^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	PMID:8924512^[25]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	PMID:21414209^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:12952975^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:12700188^[28]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034405	response to fluid shear stress	PMID:15558296^[29]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:9570757^[30]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:10909894^[31]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:25798059^[32]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:24301293^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:15980428^[34]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:619807	F		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:15980428^[34]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1306305	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:17008717^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:14699011^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0015867	ATP transport	PMID:16731531^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010652	positive regulation of cell communication by chemical coupling	PMID:15678088^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010232	vascular transport	PMID:16878174^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:21567444^[37]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009268	response to pH	PMID:14699011^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12952975^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:8944820^[38]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:15048573^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:22577485^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007154	cell communication	PMID:15685554^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:17107662^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	PMID:9851942^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	PMID:16731531^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	PMID:15048573^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:19808888^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:16731531^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:16565306^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	PMID:15048573^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	PMID:9851942^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	PMID:16515795^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16565306^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16515795^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	PMID:16162097^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:16162097^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:16162097^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:19808888^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:16162097^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:17107662^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16731531^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:16731531^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	PMID:15048573^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003158	endothelium development	PMID:10990491^[48]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003104	positive regulation of glomerular filtration	PMID:18046320^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	PMID:24728265^[50]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002544	chronic inflammatory response	PMID:23165424^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:18172080^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19723622^[52]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
involved_in	GO:0071467	cellular response to pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0061337	cardiac conduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0060156	milk ejection reflex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
involved_in	GO:0046850	regulation of bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0046849	bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0045844	positive regulation of striated muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0042110	T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0042098	T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0030500	regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
involved_in	GO:0010644	cell communication by electrical coupling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0010643	cell communication by chemical coupling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0007512	adult heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005916	fascia adherens	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	C		Seeded From UniProt	complete
enables	GO:0005243	gap junction channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	F		Seeded From UniProt	complete
involved_in	GO:0003294	atrial ventricular junction remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0002070	epithelial cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23242 ensembl:ENSMUSP00000151620	P		Seeded From UniProt	complete
part_of	GO:0005922	connexin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000500 InterPro:IPR002261 InterPro:IPR017990	C		Seeded From UniProt	complete
involved_in	GO:0007154	cell communication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000500 InterPro:IPR017990	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002261	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002261	P		Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002261	F		Seeded From UniProt	complete
involved_in	GO:0016264	gap junction assembly	PMID:15709751^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15709751^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030660	Golgi-associated vesicle membrane	Reactome:R-RNO-191736 Reactome:R-RNO-191676 Reactome:R-RNO-191616	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-RNO-191676	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-RNO-190685	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-RNO-190708 Reactome:R-RNO-190685	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005921	gap junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0303 UniProtKB-SubCell:SL-0124	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Beyer, EC et al. (1987) Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J. Cell Biol. 105 2621-9 PubMed GONUTS page
↑ Zhu, Y et al. (2016) Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 24 420-433 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Duffy, HS et al. (2004) Regulation of connexin43 protein complexes by intracellular acidification. Circ. Res. 94 215-22 PubMed GONUTS page
↑ ^4.0 ^4.1 Bouvier, D et al. (2009) Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains. J. Biol. Chem. 284 34257-71 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sorgen, PL et al. (2004) Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. J. Biol. Chem. 279 54695-701 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Seki, A et al. (2004) Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop region. Circ. Res. 95 e22-8 PubMed GONUTS page
↑ Gellhaus, A et al. (2004) Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J. Biol. Chem. 279 36931-42 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Langlois, S et al. (2008) Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Mol. Biol. Cell 19 912-28 PubMed GONUTS page
↑ Oxford, EM et al. (2007) Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells. Circ. Res. 101 703-11 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Lan, Z et al. (2005) Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Biochemistry 44 2385-96 PubMed GONUTS page
↑ Stehberg, J et al. (2012) Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J. 26 3649-57 PubMed GONUTS page
↑ Li, MW et al. (2009) Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics. Proc. Natl. Acad. Sci. U.S.A. 106 10213-8 PubMed GONUTS page
↑ Doble, BW et al. (2004) Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. J. Cell. Sci. 117 507-14 PubMed GONUTS page
↑ Dufresne, J et al. (2003) Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication. Am. J. Physiol., Cell Physiol. 284 C33-43 PubMed GONUTS page
↑ Karagiannis, J et al. (2004) Role of gap junctions in endothelium-derived hyperpolarizing factor-mediated vasodilatation in rat renal artery. Acta Pharmacol. Sin. 25 1031-7 PubMed GONUTS page
↑ Mitchell, JA et al. (2001) Parathyroid hormone-induced up-regulation of connexin-43 messenger ribonucleic acid (mRNA) is mediated by sequences within both the promoter and the 3'untranslated region of the mRNA. Endocrinology 142 907-15 PubMed GONUTS page
↑ Wang, TL et al. (2000) Regulation of connexin 43 gene expression by cyclical mechanical stretch in neonatal rat cardiomyocytes. Biochem. Biophys. Res. Commun. 267 551-7 PubMed GONUTS page
↑ ^18.0 ^18.1 Valiunas, V et al. (2001) Gap junction channels formed by coexpressed connexin40 and connexin43. Am. J. Physiol. Heart Circ. Physiol. 281 H1675-89 PubMed GONUTS page
↑ ^19.0 ^19.1 Nakano, Y et al. (2008) Connexin43 knockdown accelerates wound healing but inhibits mesenchymal transition after corneal endothelial injury in vivo. Invest. Ophthalmol. Vis. Sci. 49 93-104 PubMed GONUTS page
↑ Matsuyama, D & Kawahara, K (2009) Proliferation of neonatal cardiomyocytes by connexin43 knockdown via synergistic inactivation of p38 MAPK and increased expression of FGF1. Basic Res. Cardiol. 104 631-42 PubMed GONUTS page
↑ Hansen, DB et al. (2014) Distinct permeation profiles of the connexin 30 and 43 hemichannels. FEBS Lett. 588 1446-57 PubMed GONUTS page
↑ ^22.0 ^22.1 Parthasarathi, K et al. (2006) Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries. J. Clin. Invest. 116 2193-200 PubMed GONUTS page
↑ Maza, J et al. (2005) Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. J. Biol. Chem. 280 21115-21 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 Belliveau, DJ et al. (2006) Enhanced neurite outgrowth in PC12 cells mediated by connexin hemichannels and ATP. J. Biol. Chem. 281 20920-31 PubMed GONUTS page
↑ Orlando-Mathur, CE et al. (1996) Rat endometrial stromal cells express the gap junction genes connexins 26 and 43 and form functional gap junctions during in vitro decidualization. Biol. Reprod. 54 905-13 PubMed GONUTS page
↑ Billaud, M et al. (2011) Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension. Respir. Res. 12 30 PubMed GONUTS page
↑ ^27.0 ^27.1 Zhang, YW et al. (2003) The gap junction-independent tumor-suppressing effect of connexin 43. J. Biol. Chem. 278 44852-6 PubMed GONUTS page
↑ Mitchell, JA et al. (2003) Parathyroid hormone-related protein treatment of pregnant rats delays the increase in connexin 43 and oxytocin receptor expression in the myometrium. Biol. Reprod. 69 556-62 PubMed GONUTS page
↑ Inai, T et al. (2004) Shear stress-induced upregulation of connexin 43 expression in endothelial cells on upstream surfaces of rat cardiac valves. Histochem. Cell Biol. 122 477-83 PubMed GONUTS page
↑ Risek, B et al. (1998) Modulation of gap junction expression during transient hyperplasia of rat epidermis. J. Cell. Sci. 111 ( Pt 10) 1395-404 PubMed GONUTS page
↑ De Maio, A et al. (2000) Interruption of hepatic gap junctional communication in the rat during inflammation induced by bacterial lipopolysaccharide. Shock 14 53-9 PubMed GONUTS page
↑ Wang, N et al. (2015) MicroRNA-23a participates in estrogen deficiency induced gap junction remodeling of rats by targeting GJA1. Int. J. Biol. Sci. 11 390-403 PubMed GONUTS page
↑ Allard, C et al. (2014) Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion. J. Cereb. Blood Flow Metab. 34 339-46 PubMed GONUTS page
↑ ^34.0 ^34.1 Singh, D et al. (2005) Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. J. Biol. Chem. 280 30416-21 PubMed GONUTS page
↑ Park, DJ et al. (2006) Molecular dynamics and in vitro analysis of Connexin43: A new 14-3-3 mode-1 interacting protein. Protein Sci. 15 2344-55 PubMed GONUTS page
↑ Martin, PE et al. (2005) Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells. Br. J. Pharmacol. 144 617-27 PubMed GONUTS page
↑ Ball, KK et al. (2011) Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications. J. Neurosci. Res. 89 2052-67 PubMed GONUTS page
↑ Van Kempen, MJ et al. (1996) Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart. Cardiovasc. Res. 32 886-900 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 Desplantez, T et al. (2004) Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties. Pflugers Arch. 448 363-75 PubMed GONUTS page
↑ Li, C et al. (2012) Regulatory effect of connexin 43 on basal Ca2+ signaling in rat ventricular myocytes. PLoS ONE 7 e36165 PubMed GONUTS page
↑ Fischer, R et al. (2005) Intercellular communication via gap junctions in activated rat hepatic stellate cells. Gastroenterology 128 433-48 PubMed GONUTS page
↑ ^42.0 ^42.1 Goubaeva, F et al. (2007) Cardiac mitochondrial connexin 43 regulates apoptosis. Biochem. Biophys. Res. Commun. 352 97-103 PubMed GONUTS page
↑ ^43.0 ^43.1 Yeh, HI et al. () Individual gap junction plaques contain multiple connexins in arterial endothelium. Circ. Res. 83 1248-63 PubMed GONUTS page
↑ ^44.0 ^44.1 Leithe, E et al. (2009) Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101. J. Cell. Sci. 122 3883-93 PubMed GONUTS page
↑ ^45.0 ^45.1 Vetterlein, F et al. (2006) Redistribution of connexin43 in regional acute ischemic myocardium: influence of ischemic preconditioning. Am. J. Physiol. Heart Circ. Physiol. 291 H813-9 PubMed GONUTS page
↑ ^46.0 ^46.1 Matsuda, T et al. (2006) N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes. J. Mol. Cell. Cardiol. 40 495-502 PubMed GONUTS page
↑ ^47.0 ^47.1 ^47.2 ^47.3 Leithe, E et al. (2006) Endocytic processing of connexin43 gap junctions: a morphological study. Biochem. J. 393 59-67 PubMed GONUTS page
↑ Yeh, HI et al. (2000) Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium. J. Histochem. Cytochem. 48 1377-89 PubMed GONUTS page
↑ Takenaka, T et al. (2008) Expression and role of connexins in the rat renal vasculature. Kidney Int. 73 415-22 PubMed GONUTS page
↑ Sunagawa, M et al. (2015) Urinary bladder mucosal responses to ischemia. World J Urol 33 275-80 PubMed GONUTS page
↑ Tsuchida, S et al. (2013) Silencing the expression of connexin 43 decreases inflammation and joint destruction in experimental arthritis. J. Orthop. Res. 31 525-30 PubMed GONUTS page
↑ Sato, M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J. Biol. Chem. 284 31431-40 PubMed GONUTS page

[PMID:2826492-1] Beyer, EC et al. (1987) Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J. Cell Biol. 105 2621-9 PubMed GONUTS page

[PMID:27626200-2] Zhu, Y et al. (2016) Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 24 420-433 PubMed GONUTS page

[PMID:14699011-3] 3.0 ^3.1 ^3.2 ^3.3 Duffy, HS et al. (2004) Regulation of connexin43 protein complexes by intracellular acidification. Circ. Res. 94 215-22 PubMed GONUTS page

[PMID:19808665-4] 4.0 ^4.1 Bouvier, D et al. (2009) Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains. J. Biol. Chem. 284 34257-71 PubMed GONUTS page

[PMID:15492000-5] 5.0 ^5.1 ^5.2 Sorgen, PL et al. (2004) Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. J. Biol. Chem. 279 54695-701 PubMed GONUTS page

[PMID:15284189-6] 6.0 ^6.1 ^6.2 ^6.3 Seki, A et al. (2004) Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop region. Circ. Res. 95 e22-8 PubMed GONUTS page

[PMID:15181016-7] Gellhaus, A et al. (2004) Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. J. Biol. Chem. 279 36931-42 PubMed GONUTS page

[PMID:18162583-8] 8.0 ^8.1 ^8.2 Langlois, S et al. (2008) Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes. Mol. Biol. Cell 19 912-28 PubMed GONUTS page

[PMID:17673670-9] Oxford, EM et al. (2007) Connexin43 remodeling caused by inhibition of plakophilin-2 expression in cardiac cells. Circ. Res. 101 703-11 PubMed GONUTS page

[PMID:15709751-10] 10.0 ^10.1 ^10.2 Lan, Z et al. (2005) Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Biochemistry 44 2385-96 PubMed GONUTS page

[PMID:22665389-11] Stehberg, J et al. (2012) Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J. 26 3649-57 PubMed GONUTS page

[PMID:19509333-12] Li, MW et al. (2009) Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics. Proc. Natl. Acad. Sci. U.S.A. 106 10213-8 PubMed GONUTS page

[PMID:14702389-13] Doble, BW et al. (2004) Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. J. Cell. Sci. 117 507-14 PubMed GONUTS page

[PMID:12388089-14] Dufresne, J et al. (2003) Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication. Am. J. Physiol., Cell Physiol. 284 C33-43 PubMed GONUTS page

[PMID:15301736-15] Karagiannis, J et al. (2004) Role of gap junctions in endothelium-derived hyperpolarizing factor-mediated vasodilatation in rat renal artery. Acta Pharmacol. Sin. 25 1031-7 PubMed GONUTS page

[PMID:11159864-16] Mitchell, JA et al. (2001) Parathyroid hormone-induced up-regulation of connexin-43 messenger ribonucleic acid (mRNA) is mediated by sequences within both the promoter and the 3'untranslated region of the mRNA. Endocrinology 142 907-15 PubMed GONUTS page

[PMID:10631100-17] Wang, TL et al. (2000) Regulation of connexin 43 gene expression by cyclical mechanical stretch in neonatal rat cardiomyocytes. Biochem. Biophys. Res. Commun. 267 551-7 PubMed GONUTS page

[PMID:11557558-18] 18.0 ^18.1 Valiunas, V et al. (2001) Gap junction channels formed by coexpressed connexin40 and connexin43. Am. J. Physiol. Heart Circ. Physiol. 281 H1675-89 PubMed GONUTS page

[PMID:18172080-19] 19.0 ^19.1 Nakano, Y et al. (2008) Connexin43 knockdown accelerates wound healing but inhibits mesenchymal transition after corneal endothelial injury in vivo. Invest. Ophthalmol. Vis. Sci. 49 93-104 PubMed GONUTS page

[PMID:19377854-20] Matsuyama, D & Kawahara, K (2009) Proliferation of neonatal cardiomyocytes by connexin43 knockdown via synergistic inactivation of p38 MAPK and increased expression of FGF1. Basic Res. Cardiol. 104 631-42 PubMed GONUTS page

[PMID:24503060-21] Hansen, DB et al. (2014) Distinct permeation profiles of the connexin 30 and 43 hemichannels. FEBS Lett. 588 1446-57 PubMed GONUTS page

[PMID:16878174-22] 22.0 ^22.1 Parthasarathi, K et al. (2006) Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries. J. Clin. Invest. 116 2193-200 PubMed GONUTS page

[PMID:15817491-23] Maza, J et al. (2005) Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum. J. Biol. Chem. 280 21115-21 PubMed GONUTS page

[PMID:16731531-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 Belliveau, DJ et al. (2006) Enhanced neurite outgrowth in PC12 cells mediated by connexin hemichannels and ATP. J. Biol. Chem. 281 20920-31 PubMed GONUTS page

[PMID:8924512-25] Orlando-Mathur, CE et al. (1996) Rat endometrial stromal cells express the gap junction genes connexins 26 and 43 and form functional gap junctions during in vitro decidualization. Biol. Reprod. 54 905-13 PubMed GONUTS page

[PMID:21414209-26] Billaud, M et al. (2011) Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension. Respir. Res. 12 30 PubMed GONUTS page

[PMID:12952975-27] 27.0 ^27.1 Zhang, YW et al. (2003) The gap junction-independent tumor-suppressing effect of connexin 43. J. Biol. Chem. 278 44852-6 PubMed GONUTS page

[PMID:12700188-28] Mitchell, JA et al. (2003) Parathyroid hormone-related protein treatment of pregnant rats delays the increase in connexin 43 and oxytocin receptor expression in the myometrium. Biol. Reprod. 69 556-62 PubMed GONUTS page

[PMID:15558296-29] Inai, T et al. (2004) Shear stress-induced upregulation of connexin 43 expression in endothelial cells on upstream surfaces of rat cardiac valves. Histochem. Cell Biol. 122 477-83 PubMed GONUTS page

[PMID:9570757-30] Risek, B et al. (1998) Modulation of gap junction expression during transient hyperplasia of rat epidermis. J. Cell. Sci. 111 ( Pt 10) 1395-404 PubMed GONUTS page

[PMID:10909894-31] De Maio, A et al. (2000) Interruption of hepatic gap junctional communication in the rat during inflammation induced by bacterial lipopolysaccharide. Shock 14 53-9 PubMed GONUTS page

[PMID:25798059-32] Wang, N et al. (2015) MicroRNA-23a participates in estrogen deficiency induced gap junction remodeling of rats by targeting GJA1. Int. J. Biol. Sci. 11 390-403 PubMed GONUTS page

[PMID:24301293-33] Allard, C et al. (2014) Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion. J. Cereb. Blood Flow Metab. 34 339-46 PubMed GONUTS page

[PMID:15980428-34] 34.0 ^34.1 Singh, D et al. (2005) Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. J. Biol. Chem. 280 30416-21 PubMed GONUTS page

[PMID:17008717-35] Park, DJ et al. (2006) Molecular dynamics and in vitro analysis of Connexin43: A new 14-3-3 mode-1 interacting protein. Protein Sci. 15 2344-55 PubMed GONUTS page

[PMID:15678088-36] Martin, PE et al. (2005) Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells. Br. J. Pharmacol. 144 617-27 PubMed GONUTS page

[PMID:21567444-37] Ball, KK et al. (2011) Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications. J. Neurosci. Res. 89 2052-67 PubMed GONUTS page

[PMID:8944820-38] Van Kempen, MJ et al. (1996) Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart. Cardiovasc. Res. 32 886-900 PubMed GONUTS page

[PMID:15048573-39] 39.0 ^39.1 ^39.2 ^39.3 Desplantez, T et al. (2004) Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties. Pflugers Arch. 448 363-75 PubMed GONUTS page

[PMID:22577485-40] Li, C et al. (2012) Regulatory effect of connexin 43 on basal Ca2+ signaling in rat ventricular myocytes. PLoS ONE 7 e36165 PubMed GONUTS page

[PMID:15685554-41] Fischer, R et al. (2005) Intercellular communication via gap junctions in activated rat hepatic stellate cells. Gastroenterology 128 433-48 PubMed GONUTS page

[PMID:17107662-42] 42.0 ^42.1 Goubaeva, F et al. (2007) Cardiac mitochondrial connexin 43 regulates apoptosis. Biochem. Biophys. Res. Commun. 352 97-103 PubMed GONUTS page

[PMID:9851942-43] 43.0 ^43.1 Yeh, HI et al. () Individual gap junction plaques contain multiple connexins in arterial endothelium. Circ. Res. 83 1248-63 PubMed GONUTS page

[PMID:19808888-44] 44.0 ^44.1 Leithe, E et al. (2009) Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101. J. Cell. Sci. 122 3883-93 PubMed GONUTS page

[PMID:16565306-45] 45.0 ^45.1 Vetterlein, F et al. (2006) Redistribution of connexin43 in regional acute ischemic myocardium: influence of ischemic preconditioning. Am. J. Physiol. Heart Circ. Physiol. 291 H813-9 PubMed GONUTS page

[PMID:16515795-46] 46.0 ^46.1 Matsuda, T et al. (2006) N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes. J. Mol. Cell. Cardiol. 40 495-502 PubMed GONUTS page

[PMID:16162097-47] 47.0 ^47.1 ^47.2 ^47.3 Leithe, E et al. (2006) Endocytic processing of connexin43 gap junctions: a morphological study. Biochem. J. 393 59-67 PubMed GONUTS page

[PMID:10990491-48] Yeh, HI et al. (2000) Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium. J. Histochem. Cytochem. 48 1377-89 PubMed GONUTS page

[PMID:18046320-49] Takenaka, T et al. (2008) Expression and role of connexins in the rat renal vasculature. Kidney Int. 73 415-22 PubMed GONUTS page

[PMID:24728265-50] Sunagawa, M et al. (2015) Urinary bladder mucosal responses to ischemia. World J Urol 33 275-80 PubMed GONUTS page

[PMID:23165424-51] Tsuchida, S et al. (2013) Silencing the expression of connexin 43 decreases inflammation and joint destruction in experimental arthritis. J. Orthop. Res. 31 525-30 PubMed GONUTS page

[PMID:19723622-52] Sato, M et al. (2009) Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J. Biol. Chem. 284 31431-40 PubMed GONUTS page

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RAT:CXA1

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