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RAT:CSKP
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Cask | |
| Protein Name(s) | Peripheral plasma membrane protein CASK
Calcium/calmodulin-dependent serine protein kinase | |
| External Links | ||
| UniProt | Q62915 | |
| EMBL | U47110 | |
| RefSeq | NP_071520.1 | |
| UniGene | Rn.72627 | |
| PDB | 1RSO | |
| PDBsum | 1RSO | |
| ProteinModelPortal | Q62915 | |
| SMR | Q62915 | |
| BioGrid | 248269 | |
| IntAct | Q62915 | |
| MINT | MINT-220139 | |
| STRING | 10116.ENSRNOP00000063381 | |
| PhosphoSite | Q62915 | |
| PaxDb | Q62915 | |
| PRIDE | Q62915 | |
| GeneID | 29647 | |
| KEGG | rno:29647 | |
| UCSC | RGD:62004 | |
| CTD | 8573 | |
| RGD | 62004 | |
| eggNOG | COG0515 | |
| HOGENOM | HOG000233034 | |
| HOVERGEN | HBG001858 | |
| InParanoid | Q62915 | |
| KO | K06103 | |
| PhylomeDB | Q62915 | |
| BRENDA | 2.7.11.1 | |
| Reactome | REACT_198300 REACT_258050 | |
| EvolutionaryTrace | Q62915 | |
| NextBio | 609922 | |
| Proteomes | UP000002494 | |
| Genevestigator | Q62915 | |
| GO | GO:0060170 GO:0005737 GO:0005829 GO:0030425 GO:0016020 GO:0005634 GO:0005886 GO:0042734 GO:0043234 GO:0097060 GO:0005524 GO:0005516 GO:0004683 GO:0042043 GO:0030165 GO:0008022 GO:0032403 GO:0003713 GO:0006886 GO:0006461 GO:1903506 | |
| Gene3D | 2.30.42.10 3.40.50.300 | |
| InterPro | IPR008145 IPR008144 IPR020590 IPR011009 IPR004172 IPR014775 IPR027417 IPR001478 IPR000719 IPR002290 IPR011511 IPR001452 | |
| Pfam | PF00625 PF02828 PF00595 PF00069 PF07653 | |
| SMART | SM00072 SM00569 SM00228 SM00220 SM00326 | |
| SUPFAM | SSF50044 SSF50156 SSF52540 SSF56112 | |
| PROSITE | PS00856 PS50052 PS51022 PS50106 PS50011 PS50002 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0097060 |
synaptic membrane |
ECO:0000314 |
C |
Subfractionated rat brain homogenates into different membrane fraction. Enriched in synapse plasma membrane, figure 4. |
complete | |||||
| GO:0005886 |
plasma membrane |
ECO:0000314 |
C |
Subfractionated rat brain homogenates into different membrane fraction. Enriched in synapse plasma membrane, figure 4. |
complete | |||||
| GO:0042734 |
presynaptic membrane |
ECO:0000314 |
C |
Subcellular fractionation, Figure 4 A and B showed Cask found in membrane fraction enriched with presynaptic markers. |
complete | |||||
|
part_of |
GO:0042734 |
presynaptic membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097060 |
synaptic membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097060 |
synaptic membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0060170 |
ciliary membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042734 |
presynaptic membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098846 |
podocyte foot |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097440 |
apical dendrite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097060 |
synaptic membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072659 |
protein localization to plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:620460 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042043 |
neurexin family protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:620211 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032024 |
positive regulation of insulin secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:3649 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:620108 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:733316 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:62261 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:621660 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030165 |
PDZ domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:631330 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021987 |
cerebral cortex development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016323 |
basolateral plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:3649 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:1348952 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-RNO-6794334 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Hata, Y et al. (1996) CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J. Neurosci. 16 2488-94 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Saavedra, MV et al. (2008) Scaffolding proteins in highly purified rat olfactory cilia membranes. Neuroreport 19 1123-6 PubMed GONUTS page
- ↑ Ojeh, N et al. (2008) The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J. Cell. Sci. 121 2705-17 PubMed GONUTS page
- ↑ Lehtonen, S et al. (2005) Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Proc. Natl. Acad. Sci. U.S.A. 102 9814-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Hsueh, YP et al. (1998) Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. J. Cell Biol. 142 139-51 PubMed GONUTS page
- ↑ Leonoudakis, D et al. (2004) A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. J. Biol. Chem. 279 19051-63 PubMed GONUTS page
- ↑ Chao, HW et al. (2008) SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. J. Cell Biol. 182 141-55 PubMed GONUTS page
- ↑ 8.0 8.1 Fallon, L et al. (2002) Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J. Biol. Chem. 277 486-91 PubMed GONUTS page
- ↑ 9.0 9.1 Lehtonen, S et al. (2004) Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Am. J. Pathol. 165 923-36 PubMed GONUTS page
- ↑ 10.0 10.1 Hsueh, YP et al. (2001) Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans. J. Neurosci. 21 3764-70 PubMed GONUTS page
- ↑ Zhu, ZQ et al. (2014) Calcium/calmodulin-dependent serine protein kinase is involved in exendin-4-induced insulin secretion in INS-1 cells. Metab. Clin. Exp. 63 120-6 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Yap, CC et al. (2003) CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase. J. Neurochem. 85 123-34 PubMed GONUTS page
- ↑ Hong, CJ & Hsueh, YP (2006) CASK associates with glutamate receptor interacting protein and signaling molecules. Biochem. Biophys. Res. Commun. 351 771-6 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Leonoudakis, D et al. (2004) Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. J. Biol. Chem. 279 22331-46 PubMed GONUTS page
- ↑ Hsueh, YP et al. (2000) Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature 404 298-302 PubMed GONUTS page
- ↑ Straight, SW et al. (2000) mLin-7 is localized to the basolateral surface of renal epithelia via its NH(2) terminus. Am. J. Physiol. Renal Physiol. 278 F464-75 PubMed GONUTS page
- ↑ Schuh, K et al. (2003) Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK. J. Biol. Chem. 278 9778-83 PubMed GONUTS page
- ↑ Huang, TN & Hsueh, YP (2009) CASK point mutation regulates protein-protein interactions and NR2b promoter activity. Biochem. Biophys. Res. Commun. 382 219-22 PubMed GONUTS page
- ↑ Kuo, TY et al. (2010) X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth. J. Neurosci. Res. 88 2364-73 PubMed GONUTS page
c
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- GO:0030165 ! PDZ domain binding
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0098846 ! podocyte foot
- GO:0032024 ! positive regulation of insulin secretion
- GO:0061003 ! positive regulation of dendritic spine morphogenesis
- GO:0014069 ! postsynaptic density
- GO:0042734 ! presynaptic membrane
- GO:0044877 ! protein-containing complex binding
- GO:0032991 ! protein-containing complex
- GO:0004672 ! protein kinase activity
- GO:0072659 ! protein localization to plasma membrane
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
