RAT:CNR1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Cnr1 (synonyms: Skr6)
Protein Name(s)	Cannabinoid receptor 1 CB-R CB1 Brain-type cannabinoid receptor
External Links
UniProt	P20272
EMBL	X55812 U40395
PIR	A33117
RefSeq	NP_036916.1 XP_006238046.1
UniGene	Rn.89774
ProteinModelPortal	P20272
BioGrid	247288
IntAct	P20272
MINT	MINT-7266592
STRING	10116.ENSRNOP00000010850
BindingDB	P20272
ChEMBL	CHEMBL2111385
GuidetoPHARMACOLOGY	56
PhosphoSite	P20272
PRIDE	P20272
Ensembl	ENSRNOT00000010850
GeneID	25248
KEGG	rno:25248
UCSC	RGD:2369
CTD	1268
RGD	2369
eggNOG	NOG148018
GeneTree	ENSGT00760000118804
HOGENOM	HOG000049272
HOVERGEN	HBG051045
InParanoid	P20272
KO	K04277
OMA	VAFCVMW
OrthoDB	EOG7CK36K
PhylomeDB	P20272
TreeFam	TF330052
Reactome	REACT_233455 REACT_262979
NextBio	605857
PRO	PR:P20272
Proteomes	UP000002494
ExpressionAtlas	P20272
Genevestigator	P20272
GO	GO:0016021 GO:0005886 GO:0004949 GO:0008144 GO:0007188 GO:0007568 GO:0038171 GO:0007186 GO:0042593 GO:0007611 GO:0060135 GO:0007613 GO:0045759 GO:0045776 GO:0033602 GO:0031999 GO:0043271 GO:0033004 GO:0051001 GO:0002866 GO:0043065 GO:0045777 GO:0031622 GO:0010976 GO:0060259 GO:0050796 GO:0019216 GO:0060405 GO:0032228 GO:0051966 GO:0042220 GO:0045471 GO:0032496 GO:0043278 GO:0035094 GO:0007584 GO:0019233 GO:0007283
InterPro	IPR000810 IPR002230 IPR000276 IPR017452
PANTHER	PTHR22750:SF10
Pfam	PF00001
PIRSF	PIRSF037995
PRINTS	PR00522 PR00362 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0045121	membrane raft	PMID:21895628^[1]	ECO:0000314			C	Figure 6c: Alignment was observed between CTBs (lipid rafts)marked with red florescent proteins and the CB1 (cannabinoid receptor 1) marked with GFP. This suggests that CB1 is a membrane bound protein associated with lipid rafts.	complete CACAO 9823
	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	PMID:30217553^[2]	ECO:0000314			P	Figure 2 shows that when a CB1 agonist was infused in rats , GABA secretion increased whereas when a CB1 antagonist was introduced GABA secretion was not modified.	complete CACAO 13360
	GO:0014063	negative regulation of serotonin secretion	PMID:30217553^[2]	ECO:0000315			P	Figure 3 shows that when a CB1 agonist is infused, 5-HT secretion decreased wheres when a CB1 antagonist is infused 5-HT secretion was unmodified compared to controls. Cannabinoid receptor 1, and CB1 Rattus norvegicus (Rat).	complete CACAO 13361
involved_in	GO:0038171	cannabinoid signaling pathway	PMID:17895407^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:21895628^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17895407^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21554	P	Seeded From UniProt	complete
involved_in	GO:0060405	regulation of penile erection	PMID:17850365^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060259	regulation of feeding behavior	PMID:19575185^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060135	maternal process involved in female pregnancy	PMID:19860893^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:19725112^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051001	negative regulation of nitric-oxide synthase activity	PMID:18561998^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:19644453^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045777	positive regulation of blood pressure	PMID:19553924^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:19295473^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045759	negative regulation of action potential	PMID:20067581^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:19860799^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	PMID:19804815^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	PMID:19463710^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043271	negative regulation of ion transport	PMID:19463903^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0043231	intracellular membrane-bounded organelle	PMID:19906012^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:19560819^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	PMID:19401177^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:19463710^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033602	negative regulation of dopamine secretion	PMID:19187091^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033004	negative regulation of mast cell activation	PMID:18552882^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:19681872^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:19295473^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032228	regulation of synaptic transmission, GABAergic	PMID:19725112^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031999	negative regulation of fatty acid beta-oxidation	PMID:19724020^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031622	positive regulation of fever generation	PMID:19681872^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	PMID:20035773^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:19325539^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:19861414^[26]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:17110038^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:19666083^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:19880592^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:19807847^[30]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:19679649^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:18614700^[32]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:2165569^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:17110038^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004949	cannabinoid receptor activity	PMID:2165569^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004949	cannabinoid receptor activity	PMID:17110038^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	PMID:19282305^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0099533	positive regulation of presynaptic cytosolic calcium concentration	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0099635	P	Seeded From UniProt	complete
involved_in	GO:0099703	induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0099635	P	Seeded From UniProt	complete
involved_in	GO:0038171	cannabinoid signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21554 ensembl:ENSP00000358513	P	Seeded From UniProt	complete
involved_in	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21554 ensembl:ENSP00000358513	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21554 ensembl:ENSP00000358513	C	Seeded From UniProt	complete
enables	GO:0004949	cannabinoid receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21554 ensembl:ENSP00000358513	F	Seeded From UniProt	complete
enables	GO:0099635	voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	F	Seeded From UniProt	complete
involved_in	GO:0099553	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	P	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	C	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	C	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	C	Seeded From UniProt	complete
involved_in	GO:0098921	retrograde trans-synaptic signaling by endocannabinoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	P	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	C	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	C	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	P	Seeded From UniProt	complete
involved_in	GO:0038171	cannabinoid signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	P	Seeded From UniProt	complete
part_of	GO:0032592	integral component of mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	C	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	C	Seeded From UniProt	complete
involved_in	GO:0007413	axonal fasciculation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	C	Seeded From UniProt	complete
enables	GO:0004949	cannabinoid receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47746 ensembl:ENSMUSP00000055797	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004949	cannabinoid receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000810 InterPro:IPR002230	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000810 InterPro:IPR002230	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000810 InterPro:IPR002230 InterPro:IPR017452	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Oddi, S et al. (2012) Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. Br. J. Pharmacol. 165 2635-51 PubMed GONUTS page
↑ ^2.0 ^2.1 Cruz-Martínez, AM et al. (2018) CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Eur Neuropsychopharmacol PubMed GONUTS page
↑ ^3.0 ^3.1 Niehaus, JL et al. (2007) CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Mol. Pharmacol. 72 1557-66 PubMed GONUTS page
↑ Ghasemi, M et al. (2007) Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors. BJU Int. 100 1385-90 PubMed GONUTS page
↑ Ward, SJ et al. (2009) Age-dependent effects of the cannabinoid CB1 antagonist SR141716A on food intake, body weight change, and pruritus in rats. Psychopharmacology (Berl.) 206 155-65 PubMed GONUTS page
↑ Fonseca, BM et al. (2009) Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development. Reprod. Biol. Endocrinol. 7 121 PubMed GONUTS page
↑ ^7.0 ^7.1 Morera-Herreras, T et al. (2010) Two opposite effects of Delta(9)-tetrahydrocannabinol on subthalamic nucleus neuron activity: involvement of GABAergic and glutamatergic neurotransmission. Synapse 64 20-9 PubMed GONUTS page
↑ Cella, M et al. (2008) Dual effect of anandamide on rat placenta nitric oxide synthesis. Placenta 29 699-707 PubMed GONUTS page
↑ Getty-Kaushik, L et al. (2009) The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring) 17 1856-60 PubMed GONUTS page
↑ Mingorance, C et al. (2009) Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats. Obesity (Silver Spring) 17 1340-7 PubMed GONUTS page
↑ ^11.0 ^11.1 Villanueva, A et al. (2009) Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. Shock 32 614-20 PubMed GONUTS page
↑ Torres, E et al. (2010) Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain. J. Neurochem. 113 67-78 PubMed GONUTS page
↑ Femenía, T et al. (2010) CB1 receptor blockade decreases ethanol intake and associated neurochemical changes in fawn-hooded rats. Alcohol. Clin. Exp. Res. 34 131-41 PubMed GONUTS page
↑ Haghparast, A et al. (2009) Sub-chronic administration of AM251, CB1 receptor antagonist, within the nucleus accumbens induced sensitization to morphine in the rat. Neurosci. Lett. 467 43-7 PubMed GONUTS page
↑ ^15.0 ^15.1 Biala, G et al. (2009) Effects of rimonabant on the reinstatement of nicotine-conditioned place preference by drug priming in rats. Behav. Brain Res. 202 260-5 PubMed GONUTS page
↑ Mahmud, A et al. (2009) Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons. Neuroscience 162 1202-11 PubMed GONUTS page
↑ Osborne, KD et al. (2009) Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes. ASN Neuro 1 PubMed GONUTS page
↑ Fonseca, BM et al. (2009) Anandamide-induced cell death: dual effects in primary rat decidual cell cultures. Placenta 30 686-92 PubMed GONUTS page
↑ Rasmussen, BA et al. (2009) Methanandamide attenuates cocaine-induced hyperthermia in rats by a cannabinoid CB1-dopamine D2 receptor mechanism. Brain Res. 1260 7-14 PubMed GONUTS page
↑ O'Neill, C et al. (2009) D2 receptor-mediated inhibition of dopamine release in the rat striatum in vitro is modulated by CB1 receptors: studies using fast cyclic voltammetry. J. Neurochem. 108 545-51 PubMed GONUTS page
↑ De Filippis, D et al. (2008) Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5. Br. J. Pharmacol. 154 1672-9 PubMed GONUTS page
↑ ^22.0 ^22.1 Fraga, D et al. (2009) Endogenous cannabinoids induce fever through the activation of CB1 receptors. Br. J. Pharmacol. 157 1494-501 PubMed GONUTS page
↑ Flamment, M et al. (2009) Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 297 E1162-70 PubMed GONUTS page
↑ Hama, AT & Sagen, J () Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain. Neuropharmacology 58 758-66 PubMed GONUTS page
↑ Cota, D et al. (2009) Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Obesity (Silver Spring) 17 1641-5 PubMed GONUTS page
↑ Zorina, Y et al. (2010) Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. J. Biol. Chem. 285 1358-70 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Deshpande, LS et al. (2007) Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy. Neurosci. Lett. 411 11-6 PubMed GONUTS page
↑ Baek, Jh et al. (2009) The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. Neurosci. Lett. 464 71-3 PubMed GONUTS page
↑ Tan, H et al. (2010) Integrated cannabinoid CB1 receptor transmission within the amygdala-prefrontal cortical pathway modulates neuronal plasticity and emotional memory encoding. Cereb. Cortex 20 1486-96 PubMed GONUTS page
↑ Timofeeva, E et al. (2009) Palatable high-energy diet decreases the expression of cannabinoid type 1 receptor messenger RNA in specific brain regions in the rat. J. Neuroendocrinol. 21 982-92 PubMed GONUTS page
↑ Judge, MK et al. (2009) Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding. J. Endocrinol. 203 281-90 PubMed GONUTS page
↑ Cacciola, G et al. (2008) Expression of type-1 cannabinoid receptor during rat postnatal testicular development: possible involvement in adult leydig cell differentiation. Biol. Reprod. 79 758-65 PubMed GONUTS page
↑ ^33.0 ^33.1 Matsuda, LA et al. (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 561-4 PubMed GONUTS page
↑ Caraceni, P et al. (2009) Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia. Gut 58 1135-43 PubMed GONUTS page

[PMID:21895628-1] 1.0 ^1.1 Oddi, S et al. (2012) Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. Br. J. Pharmacol. 165 2635-51 PubMed GONUTS page

[PMID:30217553-2] 2.0 ^2.1 Cruz-Martínez, AM et al. (2018) CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Eur Neuropsychopharmacol PubMed GONUTS page

[PMID:17895407-3] 3.0 ^3.1 Niehaus, JL et al. (2007) CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Mol. Pharmacol. 72 1557-66 PubMed GONUTS page

[PMID:17850365-4] Ghasemi, M et al. (2007) Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors. BJU Int. 100 1385-90 PubMed GONUTS page

[PMID:19575185-5] Ward, SJ et al. (2009) Age-dependent effects of the cannabinoid CB1 antagonist SR141716A on food intake, body weight change, and pruritus in rats. Psychopharmacology (Berl.) 206 155-65 PubMed GONUTS page

[PMID:19860893-6] Fonseca, BM et al. (2009) Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development. Reprod. Biol. Endocrinol. 7 121 PubMed GONUTS page

[PMID:19725112-7] 7.0 ^7.1 Morera-Herreras, T et al. (2010) Two opposite effects of Delta(9)-tetrahydrocannabinol on subthalamic nucleus neuron activity: involvement of GABAergic and glutamatergic neurotransmission. Synapse 64 20-9 PubMed GONUTS page

[PMID:18561998-8] Cella, M et al. (2008) Dual effect of anandamide on rat placenta nitric oxide synthesis. Placenta 29 699-707 PubMed GONUTS page

[PMID:19644453-9] Getty-Kaushik, L et al. (2009) The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring) 17 1856-60 PubMed GONUTS page

[PMID:19553924-10] Mingorance, C et al. (2009) Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats. Obesity (Silver Spring) 17 1340-7 PubMed GONUTS page

[PMID:19295473-11] 11.0 ^11.1 Villanueva, A et al. (2009) Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. Shock 32 614-20 PubMed GONUTS page

[PMID:20067581-12] Torres, E et al. (2010) Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain. J. Neurochem. 113 67-78 PubMed GONUTS page

[PMID:19860799-13] Femenía, T et al. (2010) CB1 receptor blockade decreases ethanol intake and associated neurochemical changes in fawn-hooded rats. Alcohol. Clin. Exp. Res. 34 131-41 PubMed GONUTS page

[PMID:19804815-14] Haghparast, A et al. (2009) Sub-chronic administration of AM251, CB1 receptor antagonist, within the nucleus accumbens induced sensitization to morphine in the rat. Neurosci. Lett. 467 43-7 PubMed GONUTS page

[PMID:19463710-15] 15.0 ^15.1 Biala, G et al. (2009) Effects of rimonabant on the reinstatement of nicotine-conditioned place preference by drug priming in rats. Behav. Brain Res. 202 260-5 PubMed GONUTS page

[PMID:19463903-16] Mahmud, A et al. (2009) Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons. Neuroscience 162 1202-11 PubMed GONUTS page

[PMID:19906012-17] Osborne, KD et al. (2009) Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes. ASN Neuro 1 PubMed GONUTS page

[PMID:19560819-18] Fonseca, BM et al. (2009) Anandamide-induced cell death: dual effects in primary rat decidual cell cultures. Placenta 30 686-92 PubMed GONUTS page

[PMID:19401177-19] Rasmussen, BA et al. (2009) Methanandamide attenuates cocaine-induced hyperthermia in rats by a cannabinoid CB1-dopamine D2 receptor mechanism. Brain Res. 1260 7-14 PubMed GONUTS page

[PMID:19187091-20] O'Neill, C et al. (2009) D2 receptor-mediated inhibition of dopamine release in the rat striatum in vitro is modulated by CB1 receptors: studies using fast cyclic voltammetry. J. Neurochem. 108 545-51 PubMed GONUTS page

[PMID:18552882-21] De Filippis, D et al. (2008) Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5. Br. J. Pharmacol. 154 1672-9 PubMed GONUTS page

[PMID:19681872-22] 22.0 ^22.1 Fraga, D et al. (2009) Endogenous cannabinoids induce fever through the activation of CB1 receptors. Br. J. Pharmacol. 157 1494-501 PubMed GONUTS page

[PMID:19724020-23] Flamment, M et al. (2009) Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab. 297 E1162-70 PubMed GONUTS page

[PMID:20035773-24] Hama, AT & Sagen, J () Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain. Neuropharmacology 58 758-66 PubMed GONUTS page

[PMID:19325539-25] Cota, D et al. (2009) Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Obesity (Silver Spring) 17 1641-5 PubMed GONUTS page

[PMID:19861414-26] Zorina, Y et al. (2010) Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. J. Biol. Chem. 285 1358-70 PubMed GONUTS page

[PMID:17110038-27] 27.0 ^27.1 ^27.2 Deshpande, LS et al. (2007) Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy. Neurosci. Lett. 411 11-6 PubMed GONUTS page

[PMID:19666083-28] Baek, Jh et al. (2009) The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. Neurosci. Lett. 464 71-3 PubMed GONUTS page

[PMID:19880592-29] Tan, H et al. (2010) Integrated cannabinoid CB1 receptor transmission within the amygdala-prefrontal cortical pathway modulates neuronal plasticity and emotional memory encoding. Cereb. Cortex 20 1486-96 PubMed GONUTS page

[PMID:19807847-30] Timofeeva, E et al. (2009) Palatable high-energy diet decreases the expression of cannabinoid type 1 receptor messenger RNA in specific brain regions in the rat. J. Neuroendocrinol. 21 982-92 PubMed GONUTS page

[PMID:19679649-31] Judge, MK et al. (2009) Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding. J. Endocrinol. 203 281-90 PubMed GONUTS page

[PMID:18614700-32] Cacciola, G et al. (2008) Expression of type-1 cannabinoid receptor during rat postnatal testicular development: possible involvement in adult leydig cell differentiation. Biol. Reprod. 79 758-65 PubMed GONUTS page

[PMID:2165569-33] 33.0 ^33.1 Matsuda, LA et al. (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 561-4 PubMed GONUTS page

[PMID:19282305-34] Caraceni, P et al. (2009) Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia. Gut 58 1135-43 PubMed GONUTS page

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