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RAT:CHP1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Chp1 (synonyms: Chp) | |
| Protein Name(s) | Calcineurin B homologous protein 1
Calcineurin B-like protein Calcium-binding protein CHP Calcium-binding protein p22 EF-hand calcium-binding domain-containing protein p22 | |
| External Links | ||
| UniProt | P61023 | |
| EMBL | U39875 AB070350 BC062029 | |
| RefSeq | NP_077053.1 | |
| UniGene | Rn.11041 | |
| PDB | 2CT9 | |
| PDBsum | 2CT9 | |
| ProteinModelPortal | P61023 | |
| SMR | P61023 | |
| IntAct | P61023 | |
| MINT | MINT-1786138 | |
| STRING | 10116.ENSRNOP00000053243 | |
| PhosphoSitePlus | P61023 | |
| PaxDb | P61023 | |
| PRIDE | P61023 | |
| Ensembl | ENSRNOT00000056405 | |
| GeneID | 64152 | |
| KEGG | rno:64152 | |
| UCSC | RGD:620447 | |
| CTD | 11261 | |
| RGD | 620447 | |
| eggNOG | KOG0034 COG5126 | |
| GeneTree | ENSGT00860000133729 | |
| HOGENOM | HOG000233019 | |
| HOVERGEN | HBG105307 | |
| InParanoid | P61023 | |
| KO | K17610 | |
| OMA | KSKDQNG | |
| OrthoDB | EOG091G0LZ1 | |
| PhylomeDB | P61023 | |
| TreeFam | TF354284 | |
| Reactome | [www.reactome.org/content/detail/R-RNO-2160916 R-RNO-2160916] | |
| EvolutionaryTrace | P61023 | |
| PRO | PR:P61023 | |
| Proteomes | UP000002494 | |
| Bgee | ENSRNOG00000004742 | |
| Genevisible | P61023 | |
| GO | GO:0005737 GO:0005829 GO:0005783 GO:0005793 GO:0070062 GO:0005925 GO:0000139 GO:0015630 GO:0005634 GO:0005886 GO:0030133 GO:0005509 GO:0048306 GO:0019900 GO:0008017 GO:0004860 GO:0005215 GO:0017156 GO:0019722 GO:0071468 GO:0031122 GO:0022406 GO:0061025 GO:0061024 GO:0001578 GO:0070885 GO:0032088 GO:0010923 GO:0031953 GO:0042308 GO:0006469 GO:0001933 GO:0031397 GO:0060050 GO:0090314 GO:0051222 GO:0032417 GO:0006611 GO:0051259 GO:0050821 GO:0051453 GO:1901214 | |
| CDD | cd00051 | |
| Gene3D | 1.10.238.10 | |
| InterPro | IPR011992 IPR018247 IPR002048 | |
| Pfam | PF13499 | |
| SMART | SM00054 | |
| SUPFAM | SSF47473 | |
| PROSITE | PS00018 PS50222 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0090314 |
positive regulation of protein targeting to membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071468 |
cellular response to acidic pH |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070885 |
negative regulation of calcineurin-NFAT signaling cascade |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061025 |
membrane fusion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061024 |
membrane organization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060050 |
positive regulation of protein glycosylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051453 |
regulation of intracellular pH |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051222 |
positive regulation of protein transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042308 |
negative regulation of protein import into nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032417 |
positive regulation of sodium:proton antiporter activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032417 |
positive regulation of sodium:proton antiporter activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031953 |
negative regulation of protein autophosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031397 |
negative regulation of protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031122 |
cytoplasmic microtubule organization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030133 |
transport vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022406 |
membrane docking |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019900 |
kinase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015630 |
microtubule cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015630 |
microtubule cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0015630 |
microtubule cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010923 |
negative regulation of phosphatase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006611 |
protein export from nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005215 |
transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001578 |
microtubule bundle formation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0017156 |
calcium ion regulated exocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901214 |
regulation of neuron death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070885 |
negative regulation of calcineurin-NFAT signaling cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051453 |
regulation of intracellular pH |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042308 |
negative regulation of protein import into nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032417 |
positive regulation of sodium:proton antiporter activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010923 |
negative regulation of phosphatase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q99653 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019722 |
calcium-mediated signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004860 |
protein kinase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005793 |
endoplasmic reticulum-Golgi intermediate compartment |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0012505 |
endomembrane system |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Barroso, MR et al. (1996) A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic. J. Biol. Chem. 271 10183-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Andrade, J et al. (2004) The EF-hand Ca2+-binding protein p22 plays a role in microtubule and endoplasmic reticulum organization and dynamics with distinct Ca2+-binding requirements. Mol. Biol. Cell 15 481-96 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Matsushita, M et al. (2011) Dual functional significance of calcineurin homologous protein 1 binding to Na(+)/H(+) exchanger isoform 1. Am. J. Physiol., Cell Physiol. 301 C280-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Kuwahara, H et al. (2003) The apoptosis-inducing protein kinase DRAK2 is inhibited in a calcium-dependent manner by the calcium-binding protein CHP. J. Biochem. 134 245-50 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Andrade, J et al. (2004) Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules. Biochem. J. 384 327-36 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Timm, S et al. (1999) The EF-hand Ca(2+)-binding protein p22 associates with microtubules in an N-myristoylation-dependent manner. Mol. Biol. Cell 10 3473-88 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Nagita, M et al. (2003) Two nuclear export signals specify the cytoplasmic localization of calcineurin B homologous protein 1. J. Biochem. 134 919-25 PubMed GONUTS page
- ↑ 8.0 8.1 Knaapen, M et al. () Prevalence of left and balanced coronary arterial dominance decreases with increasing age of patients at autopsy. A postmortem coronary angiograms study. Cardiovasc. Pathol. 22 49-53 PubMed GONUTS page
c
- GO:0048306 ! calcium-dependent protein binding
- GO:0017156 ! calcium-ion regulated exocytosis
- GO:0019722 ! calcium-mediated signaling
- GO:0005509 ! calcium ion binding
- GO:0071468 ! cellular response to acidic pH
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
- GO:0031122 ! cytoplasmic microtubule organization
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
m
- Mammalia
- GO:0016020 ! membrane
- GO:0022406 ! membrane docking
- GO:0061025 ! membrane fusion
- GO:0061024 ! membrane organization
- GO:0046872 ! metal ion binding
- Metazoa
- GO:0001578 ! microtubule bundle formation
- GO:0015630 ! microtubule cytoskeleton
- GO:0008017 ! microtubule binding
- Muridae
- Murinae
- Muroidea
n
- GO:0001933 ! negative regulation of protein phosphorylation
- GO:0006469 ! negative regulation of protein kinase activity
- GO:0010923 ! negative regulation of phosphatase activity
- GO:0031397 ! negative regulation of protein ubiquitination
- GO:0031953 ! negative regulation of protein autophosphorylation
- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:0042308 ! negative regulation of protein import into nucleus
- GO:0070885 ! negative regulation of calcineurin-NFAT signaling cascade
- GO:0005634 ! nucleus
p
- GO:0005886 ! plasma membrane
- GO:0090314 ! positive regulation of protein targeting to membrane
- GO:0051222 ! positive regulation of protein transport
- GO:0032417 ! positive regulation of sodium:proton antiporter activity
- GO:0060050 ! positive regulation of protein glycosylation
- GO:0051259 ! protein complex oligomerization
- GO:0006611 ! protein export from nucleus
- GO:0004860 ! protein kinase inhibitor activity
- GO:0050821 ! protein stabilization
- GO:0015031 ! protein transport
