RAT:ARRB2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Arrb2
Protein Name(s)	Beta-arrestin-2 Arrestin beta-2
External Links
UniProt	P29067
EMBL	M91590 BC087578 U03627 AF051457
PIR	A59279
RefSeq	NP_037043.1
UniGene	Rn.32973
ProteinModelPortal	P29067
SMR	P29067
BioGrid	247426
DIP	DIP-40507N
IntAct	P29067
MINT	MINT-151424
STRING	10116.ENSRNOP00000026207
PhosphoSite	P29067
PRIDE	P29067
Ensembl	ENSRNOT00000026207
GeneID	25388
KEGG	rno:25388
UCSC	RGD:2157
CTD	409
RGD	2157
eggNOG	NOG302111
GeneTree	ENSGT00390000013152
HOGENOM	HOG000231319
HOVERGEN	HBG002399
InParanoid	P29067
KO	K04439
OMA	KPHDHIT
OrthoDB	EOG79W954
PhylomeDB	P29067
Reactome	REACT_194345 REACT_198398 REACT_262448
NextBio	606447
PRO	PR:P29067
Proteomes	UP000002494
Genevestigator	P29067
GO	GO:0016323 GO:0005905 GO:0005737 GO:0043197 GO:0030139 GO:0005634 GO:0014069 GO:0045211 GO:0071889 GO:0031691 GO:0031692 GO:0030276 GO:0031748 GO:0031762 GO:0001664 GO:0051019 GO:0032403 GO:0019904 GO:0031702 GO:0031826 GO:0007628 GO:0007420 GO:0060326 GO:0002032 GO:0050965 GO:0006897 GO:0042699 GO:0002031 GO:0007186 GO:0043154 GO:0034260 GO:0032691 GO:0032695 GO:0032715 GO:0045953 GO:0032088 GO:0031397 GO:0090201 GO:0034392 GO:0034122 GO:0032720 GO:0051928 GO:2000573 GO:0070374 GO:0033138 GO:0050731 GO:0051897 GO:0001934 GO:0031398 GO:0002092 GO:0032226 GO:0043161 GO:0015031 GO:0016567 GO:0060765 GO:0030817 GO:0030820 GO:0008277 GO:0006366 GO:0007179
Gene3D	2.60.40.640 2.60.40.840
InterPro	IPR000698 IPR011021 IPR014752 IPR011022 IPR017864 IPR014753 IPR014756
PANTHER	PTHR11792
Pfam	PF02752 PF00339
PRINTS	PR00309
SMART	SM01017
SUPFAM	SSF81296
PROSITE	PS00295

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:1990763	arrestin family protein binding	PMID:23886940^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N5I2	F	Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P32121	C	Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	PMID:19254952^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904037	positive regulation of epithelial cell apoptotic process	PMID:24719556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	PMID:19171933^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	PMID:19008961^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:28274926^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:19254952^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:19171933^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	PMID:21078978^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:19171933^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	PMID:19200235^[8]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:70500	F	Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	PMID:19200235^[8]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3046	F	Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	PMID:21926413^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:19254952^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:157224^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:1517224^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:15498833^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:26621121^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:1517224^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:19171933^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042699	follicle-stimulating hormone signaling pathway	PMID:16899567^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034392	negative regulation of smooth muscle cell apoptotic process	PMID:19171933^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	PMID:1517224^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:19171933^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	PMID:28274926^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031859	platelet activating factor receptor binding	PMID:23911909^[15]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:61897	F	Seeded From UniProt	complete
enables	GO:0031826	type 2A serotonin receptor binding	PMID:19919577^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:734107	F	Seeded From UniProt	complete
NOT\|enables	GO:0031826	type 2A serotonin receptor binding	PMID:19919577^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:61800	F	Seeded From UniProt	complete
enables	GO:0031762	follicle-stimulating hormone receptor binding	PMID:16899567^[14]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2632	F	Seeded From UniProt	complete
enables	GO:0031748	D1 dopamine receptor binding	PMID:19200235^[8]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2518	F	Seeded From UniProt	complete
enables	GO:0031702	type 1 angiotensin receptor binding	PMID:19522833^[17]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2070	F	Seeded From UniProt	complete
enables	GO:0031692	alpha-1B adrenergic receptor binding	PMID:18523139^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0031691	alpha-1A adrenergic receptor binding	PMID:18523139^[18]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:736081	F	Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:20650893^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:12890920^[20]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2520	F	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:16899567^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:1517224^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	PMID:1517224^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:11823056^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:157224^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:12600992^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:25016018^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16899567^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:16120787^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	PMID:20705669^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:19254952^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17984062^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29067	F	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
involved_in	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
involved_in	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
enables	GO:0032947	protein-containing complex scaffold activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F	Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
enables	GO:0031701	angiotensin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F	Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C	Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F	Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
involved_in	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	P	Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32121 ensembl:ENSP00000403701	F	Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	F	Seeded From UniProt	complete
involved_in	GO:0034122	negative regulation of toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0032695	negative regulation of interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0032226	positive regulation of synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0008277	regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91YI4 ensembl:ENSMUSP00000104208	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000698 InterPro:IPR014753	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Puca, L et al. (2013) Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. J. Cell. Sci. 126 4457-68 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Kim, J et al. (2009) Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. J. Biol. Chem. 284 11953-62 PubMed GONUTS page
↑ Chen, W et al. (2014) Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension. Int. J. Biol. Sci. 10 386-95 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Ahn, S et al. (2009) {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. J. Biol. Chem. 284 8855-65 PubMed GONUTS page
↑ Molla-Herman, A et al. (2008) Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control. PLoS ONE 3 e3728 PubMed GONUTS page
↑ ^6.0 ^6.1 Wang, Y et al. (2017) β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis. Am. J. Physiol. Renal Physiol. 313 F1-F8 PubMed GONUTS page
↑ Tzingounis, AV et al. (2010) {Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism. Proc. Natl. Acad. Sci. U.S.A. 107 21028-33 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Chen, J et al. (2009) Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Eur. J. Neurosci. 29 287-306 PubMed GONUTS page
↑ Yang, CH et al. (2011) Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats. Br J Anaesth 107 774-81 PubMed GONUTS page
↑ ^10.0 ^10.1 Horton, JE et al. (1979) Partial purification of a bone-resorbing factor elaborated from human allogeneic cultures. Cell. Immunol. 43 1-10 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Attramadal, H et al. (1992) Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J. Biol. Chem. 267 17882-90 PubMed GONUTS page
↑ Fessart, D et al. (2005) c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization. Mol. Endocrinol. 19 491-503 PubMed GONUTS page
↑ Wang, WY et al. (2016) Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. Neuroscience 313 199-212 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Marion, S et al. (2006) G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells. J. Endocrinol. 190 341-50 PubMed GONUTS page
↑ Kim, YH et al. (2013) PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway. J. Lipid Res. 54 2678-86 PubMed GONUTS page
↑ ^16.0 ^16.1 Bhattacharya, A et al. (2010) Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions. J. Neurochem. 112 723-32 PubMed GONUTS page
↑ Hennenberg, M et al. (2009) Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis. Eur. J. Clin. Invest. 39 906-13 PubMed GONUTS page
↑ ^18.0 ^18.1 Stanasila, L et al. (2008) Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. Mol. Pharmacol. 74 562-73 PubMed GONUTS page
↑ Shukla, AK et al. (2010) Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J. Biol. Chem. 285 30115-25 PubMed GONUTS page
↑ Kyoi, S et al. (2003) Loss of intracellular dystrophin: a potential mechanism for myocardial reperfusion injury. Circ. J. 67 725-7 PubMed GONUTS page
↑ Gurevich, EV et al. (2002) Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience 109 421-36 PubMed GONUTS page
↑ Wang, J & Liu, XJ (2003) A G protein-coupled receptor kinase induces Xenopus oocyte maturation. J. Biol. Chem. 278 15809-14 PubMed GONUTS page
↑ Khoury, E et al. (2014) Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK. J. Biol. Chem. 289 23302-17 PubMed GONUTS page
↑ Haberstock-Debic, H et al. (2005) Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. J. Neurosci. 25 7847-57 PubMed GONUTS page
↑ Morris, GE et al. (2011) G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. Cardiovasc. Res. 89 193-203 PubMed GONUTS page
↑ Boularan, C et al. (2007) beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53. Proc. Natl. Acad. Sci. U.S.A. 104 18061-6 PubMed GONUTS page

[PMID:23886940-1] Puca, L et al. (2013) Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. J. Cell. Sci. 126 4457-68 PubMed GONUTS page

[PMID:19254952-2] 2.0 ^2.1 ^2.2 ^2.3 Kim, J et al. (2009) Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. J. Biol. Chem. 284 11953-62 PubMed GONUTS page

[PMID:24719556-3] Chen, W et al. (2014) Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension. Int. J. Biol. Sci. 10 386-95 PubMed GONUTS page

[PMID:19171933-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Ahn, S et al. (2009) {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. J. Biol. Chem. 284 8855-65 PubMed GONUTS page

[PMID:19008961-5] Molla-Herman, A et al. (2008) Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control. PLoS ONE 3 e3728 PubMed GONUTS page

[PMID:28274926-6] 6.0 ^6.1 Wang, Y et al. (2017) β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis. Am. J. Physiol. Renal Physiol. 313 F1-F8 PubMed GONUTS page

[PMID:21078978-7] Tzingounis, AV et al. (2010) {Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism. Proc. Natl. Acad. Sci. U.S.A. 107 21028-33 PubMed GONUTS page

[PMID:19200235-8] 8.0 ^8.1 ^8.2 Chen, J et al. (2009) Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Eur. J. Neurosci. 29 287-306 PubMed GONUTS page

[PMID:21926413-9] Yang, CH et al. (2011) Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats. Br J Anaesth 107 774-81 PubMed GONUTS page

[PMID:157224-10] 10.0 ^10.1 Horton, JE et al. (1979) Partial purification of a bone-resorbing factor elaborated from human allogeneic cultures. Cell. Immunol. 43 1-10 PubMed GONUTS page

[PMID:1517224-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Attramadal, H et al. (1992) Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J. Biol. Chem. 267 17882-90 PubMed GONUTS page

[PMID:15498833-12] Fessart, D et al. (2005) c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization. Mol. Endocrinol. 19 491-503 PubMed GONUTS page

[PMID:26621121-13] Wang, WY et al. (2016) Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. Neuroscience 313 199-212 PubMed GONUTS page

[PMID:16899567-14] 14.0 ^14.1 ^14.2 ^14.3 Marion, S et al. (2006) G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells. J. Endocrinol. 190 341-50 PubMed GONUTS page

[PMID:23911909-15] Kim, YH et al. (2013) PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway. J. Lipid Res. 54 2678-86 PubMed GONUTS page

[PMID:19919577-16] 16.0 ^16.1 Bhattacharya, A et al. (2010) Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions. J. Neurochem. 112 723-32 PubMed GONUTS page

[PMID:19522833-17] Hennenberg, M et al. (2009) Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis. Eur. J. Clin. Invest. 39 906-13 PubMed GONUTS page

[PMID:18523139-18] 18.0 ^18.1 Stanasila, L et al. (2008) Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. Mol. Pharmacol. 74 562-73 PubMed GONUTS page

[PMID:20650893-19] Shukla, AK et al. (2010) Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J. Biol. Chem. 285 30115-25 PubMed GONUTS page

[PMID:12890920-20] Kyoi, S et al. (2003) Loss of intracellular dystrophin: a potential mechanism for myocardial reperfusion injury. Circ. J. 67 725-7 PubMed GONUTS page

[PMID:11823056-21] Gurevich, EV et al. (2002) Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience 109 421-36 PubMed GONUTS page

[PMID:12600992-22] Wang, J & Liu, XJ (2003) A G protein-coupled receptor kinase induces Xenopus oocyte maturation. J. Biol. Chem. 278 15809-14 PubMed GONUTS page

[PMID:25016018-23] Khoury, E et al. (2014) Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK. J. Biol. Chem. 289 23302-17 PubMed GONUTS page

[PMID:16120787-24] Haberstock-Debic, H et al. (2005) Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. J. Neurosci. 25 7847-57 PubMed GONUTS page

[PMID:20705669-25] Morris, GE et al. (2011) G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. Cardiovasc. Res. 89 193-203 PubMed GONUTS page

[PMID:17984062-26] Boularan, C et al. (2007) beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53. Proc. Natl. Acad. Sci. U.S.A. 104 18061-6 PubMed GONUTS page

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RAT:ARRB2

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