PMID:20705669

Citation	Morris, GE, Nelson, CP, Everitt, D, Brighton, PJ, Standen, NB, Challiss, RA and Willets, JM (2011) G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. Cardiovasc. Res. 89:193-203
Abstract	prolonged P2Y-receptor signalling can cause vasoconstriction leading to hypertension, vascular smooth muscle hypertrophy, and hyperplasia. G protein-coupled receptor signalling is negatively regulated by G protein-coupled receptor kinases (GRKs) and arrestin proteins, preventing prolonged or inappropriate signalling. This study investigates whether GRKs and arrestins regulate uridine 5'-triphosphate (UTP)-stimulated contractile signalling in adult Wistar rat mesenteric arterial smooth muscle cells (MSMCs).
Links	PubMed PMC3002865 Online version:10.1093/cvr/cvq249
Keywords	Animals; Arrestins/antagonists & inhibitors; Arrestins/genetics; Arrestins/metabolism; Base Sequence; Calcium Signaling; G-Protein-Coupled Receptor Kinase 2/metabolism; Male; Mesenteric Arteries/drug effects; Mesenteric Arteries/physiology; Muscle Contraction/drug effects; Muscle Contraction/physiology; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/metabolism; RNA, Small Interfering/genetics; Rats; Rats, Wistar; Receptors, Purinergic P2Y/classification; Receptors, Purinergic P2Y/genetics; Receptors, Purinergic P2Y/metabolism; Receptors, Purinergic P2Y2/genetics; Receptors, Purinergic P2Y2/metabolism; Signal Transduction; Uridine Triphosphate/metabolism; Uridine Triphosphate/pharmacology
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:ARRB2	involved_in	GO:0002032: desensitization of G protein-coupled receptor signaling pathway by arrestin	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.