PIG:P53

Species (Taxon ID)	Sus scrofa (Pig). (9823)
Gene Name(s)	TP53 (synonyms: P53)
Protein Name(s)	Cellular tumor antigen p53 Tumor suppressor p53
External Links
UniProt	Q9TUB2
EMBL	AF098067
RefSeq	NP_998989.3
UniGene	Ssc.15917
ProteinModelPortal	Q9TUB2
SMR	Q9TUB2
STRING	9823.ENSSSCP00000019016
Ensembl	ENSSSCT00000019534
GeneID	397276
KEGG	ssc:397276
CTD	7157
eggNOG	NOG80479
GeneTree	ENSGT00390000015092
HOGENOM	HOG000039957
HOVERGEN	HBG005201
InParanoid	Q9TUB2
KO	K04451
OMA	SQKTYPG
OrthoDB	EOG7JQBNW
TreeFam	TF106101
Reactome	REACT_191907 REACT_193624 REACT_206415 REACT_208274 REACT_209752 REACT_215313 REACT_220527
Proteomes	UP000008227
GO	GO:0005737 GO:0005829 GO:0005783 GO:0005759 GO:0005739 GO:0000790 GO:0016363 GO:0005730 GO:0005634 GO:0016605 GO:0005657 GO:0005669 GO:0005524 GO:0003682 GO:0005507 GO:0003677 GO:0035033 GO:0001077 GO:0000979 GO:0002326 GO:0007569 GO:0035690 GO:0042149 GO:0071456 GO:0071479 GO:0034644 GO:0021549 GO:0031497 GO:0008340 GO:0006977 GO:0006978 GO:0000733 GO:0006302 GO:0048568 GO:0006983 GO:0007369 GO:0001701 GO:0042771 GO:0071850 GO:0035264 GO:0007275 GO:0070266 GO:0043066 GO:0030308 GO:0008156 GO:0048147 GO:1901525 GO:0007406 GO:2000378 GO:0000122 GO:0030512 GO:0051402 GO:0006289 GO:0097252 GO:0090403 GO:0010666 GO:0090343 GO:0031065 GO:2001244 GO:0035794 GO:0043525 GO:0050731 GO:0032461 GO:2000379 GO:0090200 GO:0070245 GO:0000060 GO:0051262 GO:0007265 GO:1902108 GO:0034103 GO:0001836 GO:0090399 GO:0046677 GO:0010332 GO:0002931 GO:0009651 GO:0010165 GO:0009303 GO:0001756 GO:0033077 GO:0002360 GO:0002309 GO:0007179
Gene3D	2.60.40.720 4.10.170.10
InterPro	IPR008967 IPR012346 IPR011615 IPR010991 IPR013872 IPR002117
PANTHER	PTHR11447
Pfam	PF00870 PF08563 PF07710
PRINTS	PR00386
SUPFAM	SSF47719 SSF49417
PROSITE	PS00348

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0032306	regulation of prostaglandin secretion	PMID:18703674^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_output:(CHEBI:26340) occurs_in:(CL:0000501)\|has_output(CHEBI:15551) occurs_in:(CL:0000501)	Seeded From UniProt	complete
involved_in	GO:0090276	regulation of peptide hormone secretion	PMID:18703674^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_output:(CHEBI:7872) occurs_in:(CL:0000501)	Seeded From UniProt	complete
involved_in	GO:2000871	negative regulation of progesterone secretion	PMID:18703674^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000501)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18703674^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000501)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
involved_in	GO:0048512	circadian behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0043153	entrainment of circadian clock by photoperiod	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0097252	oligodendrocyte apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:0000733	DNA strand renaturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011615	F		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010991 InterPro:IPR036674	P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1210	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Sirotkin, AV et al. (2008) Transcription factor p53 can regulate proliferation, apoptosis and secretory activity of luteinizing porcine ovarian granulosa cell cultured with and without ghrelin and FSH. Reproduction 136 611-8 PubMed GONUTS page

[PMID:18703674-1] 1.0 ^1.1 ^1.2 ^1.3 Sirotkin, AV et al. (2008) Transcription factor p53 can regulate proliferation, apoptosis and secretory activity of luteinizing porcine ovarian granulosa cell cultured with and without ghrelin and FSH. Reproduction 136 611-8 PubMed GONUTS page

[1]

PIG:P53

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