PIG:HMGB2

Species (Taxon ID)	Sus scrofa (Pig). (9823)
Gene Name(s)	HMGB2 (synonyms: HMG2)
Protein Name(s)	High mobility group protein B2 High mobility group protein 2 HMG-2
External Links
UniProt	P17741
EMBL	J02895
PIR	A34719
RefSeq	NP_999228.1
UniGene	Ssc.226
PDB	1J3C 1J3D 1J3X
PDBsum	1J3C 1J3D 1J3X
ProteinModelPortal	P17741
SMR	P17741
STRING	9823.ENSSSCP00000010363
PaxDb	P17741
GeneID	397130
KEGG	ssc:397130
CTD	3148
eggNOG	KOG0381 COG5648
HOGENOM	HOG000197861
HOVERGEN	HBG009000
InParanoid	P17741
KO	K11295
EvolutionaryTrace	P17741
Proteomes	UP000008227
GO	GO:0005623 GO:0000793 GO:0005737 GO:0005615 GO:0000790 GO:0005634 GO:0048471 GO:0003677 GO:0008301 GO:0003690 GO:0008144 GO:0001158 GO:0000400 GO:0044378 GO:0019904 GO:0003697 GO:0097100 GO:0008134 GO:0006935 GO:0050829 GO:0050830 GO:0032392 GO:0051103 GO:0006310 GO:0006265 GO:0002437 GO:0045087 GO:0008584 GO:1902042 GO:0010629 GO:0006334 GO:0043388 GO:0010628 GO:0045944 GO:0050767 GO:0072091 GO:0006357 GO:0042493 GO:0032496 GO:0048545 GO:0007289 GO:0007283 GO:0006351
Gene3D	1.10.30.10
InterPro	IPR009071 IPR017967 IPR031075
PANTHER	PTHR13711:SF217
Pfam	PF00505 PF09011
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS00353 PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1904877	positive regulation of DNA ligase activity	PMID:9600082^[1]	ECO:0000314			P		Figure 4	complete CACAO 11224
enables	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	F		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5U071	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5U071	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	F		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C	part_of:(CL:0000775)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:2465778^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002370)	Seeded From UniProt	complete
enables	GO:0097100	supercoiled DNA binding	PMID:2465778^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006334	nucleosome assembly	PMID:2465778^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:3571199^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002370)	Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:9600082^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002370)	Seeded From UniProt	complete
involved_in	GO:0072091	regulation of stem cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0072091	regulation of stem cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:X2JGB1	P	occurs_in:(CL:0000738) occurs_in:(UBERON:0002106) occurs_in:(UBERON:0002113)	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:X2JGB1	P	occurs_in:(UBERON:0002106) occurs_in:(UBERON:0002113)	Seeded From UniProt	complete
enables	GO:0044378	non-sequence-specific DNA binding, bending	PMID:11275566^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0097100	supercoiled DNA binding	PMID:11275566^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:11275566^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C	part_of:(CL:0000775) part_of:(CL:0000542)	Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	PMID:11754747^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:11754747^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26584	F		Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1NPU8	F		Seeded From UniProt	complete
involved_in	GO:0032392	DNA geometric change	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26584	P		Seeded From UniProt	complete
involved_in	GO:0032392	DNA geometric change	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1NPU8	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	C		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0002437	inflammatory response to antigenic stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0002437	inflammatory response to antigenic stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	F		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0007289	spermatid nucleus differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3U566	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P30681	C		Seeded From UniProt	complete
involved_in	GO:0051103	DNA ligation involved in DNA repair	PMID:9600082^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:11275566^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	P		Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	PMID:11275566^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11275566^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26583	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P26583 WB:WBGene00001972	P		Seeded From UniProt	complete
involved_in	GO:0045089	positive regulation of innate immune response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682	P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004362 FB:FBgn0278608 PANTHER:PTN000345179 RGD:2802 SGD:S000002157 SGD:S000004676 SGD:S000006256 UniProtKB:F1RJ01 UniProtKB:F2Z594 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P12682 UniProtKB:P17741 UniProtKB:P26583 UniProtKB:P26584 UniProtKB:P40618 UniProtKB:P40673 UniProtKB:Q32L31 UniProtKB:Q8I616 UniProtKB:Q8IB14 UniProtKB:Q9YH06	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0278608 MGI:MGI:96157 PANTHER:PTN000345179 RGD:2802 UniProtKB:P09429	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0278608 MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN000346026 UniProtKB:P09429 UniProtKB:P26583 WB:WBGene00001972	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000345179 SGD:S000002157 SGD:S000006256	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009623 UniProtKB:P09429 UniProtKB:P10103 UniProtKB:P40673 UniProtKB:Q32L31	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96113 MGI:MGI:96157 PANTHER:PTN001009623 RGD:2802 UniProtKB:P26583	C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96157 PANTHER:PTN000346026 SGD:S000002160 UniProtKB:F1RJ01 UniProtKB:F2Z594 UniProtKB:P12682 UniProtKB:P17741	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017967	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017967	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Nagaki, S et al. (1998) Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks. Biochem. Biophys. Res. Commun. 246 137-41 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Waga, S et al. (1989) Nonhistone proteins HMG1 and HMG2 suppress the nucleosome assembly at physiological ionic strength. Biochim. Biophys. Acta 1007 209-14 PubMed GONUTS page
↑ Yoshida, M (1987) High glutamic and aspartic region in nonhistone protein HMG(1+2) unwinds DNA double helical structure. J. Biochem. 101 175-80 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Nakamura, Y et al. (2001) HMG box A in HMG2 protein functions as a mediator of DNA structural alteration together with box B. J. Biochem. 129 643-51 PubMed GONUTS page
↑ ^5.0 ^5.1 Nakamura, Y et al. (2002) Distorted DNA structures induced by HMGB2 possess a high affinity for HMGB2. J. Biochem. 131 153-60 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9600082-1] 1.0 ^1.1 ^1.2 Nagaki, S et al. (1998) Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks. Biochem. Biophys. Res. Commun. 246 137-41 PubMed GONUTS page

[PMID:2465778-2] 2.0 ^2.1 ^2.2 Waga, S et al. (1989) Nonhistone proteins HMG1 and HMG2 suppress the nucleosome assembly at physiological ionic strength. Biochim. Biophys. Acta 1007 209-14 PubMed GONUTS page

[PMID:3571199-3] Yoshida, M (1987) High glutamic and aspartic region in nonhistone protein HMG(1+2) unwinds DNA double helical structure. J. Biochem. 101 175-80 PubMed GONUTS page

[PMID:11275566-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Nakamura, Y et al. (2001) HMG box A in HMG2 protein functions as a mediator of DNA structural alteration together with box B. J. Biochem. 129 643-51 PubMed GONUTS page

[PMID:11754747-5] 5.0 ^5.1 Nakamura, Y et al. (2002) Distorted DNA structures induced by HMGB2 possess a high affinity for HMGB2. J. Biochem. 131 153-60 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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PIG:HMGB2

Contents

Annotations

Notes

References

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