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PIG:HMGB1
Contents
| Species (Taxon ID) | Sus scrofa (Pig). (9823) | |
| Gene Name(s) | HMGB1 (synonyms: HMG1) | |
| Protein Name(s) | High mobility group protein B1
High mobility group protein 1 HMG-1 | |
| External Links | ||
| UniProt | P12682 | |
| EMBL | M21683 | |
| PIR | A28897 | |
| RefSeq | NP_001004034.1 | |
| UniGene | Ssc.22696 | |
| ProteinModelPortal | P12682 | |
| SMR | P12682 | |
| IntAct | P12682 | |
| STRING | 9823.ENSSSCP00000009955 | |
| PaxDb | P12682 | |
| PRIDE | P12682 | |
| GeneID | 445521 | |
| KEGG | ssc:445521 | |
| CTD | 3146 | |
| eggNOG | KOG0381 COG5648 | |
| HOGENOM | HOG000197861 | |
| HOVERGEN | HBG009000 | |
| InParanoid | P12682 | |
| KO | K10802 | |
| Proteomes | UP000008227 | |
| GO | GO:0005623 GO:0000793 GO:0005793 GO:0005768 GO:0005576 GO:0000790 GO:0005886 GO:0000405 GO:0000400 GO:0044378 GO:0097100 GO:0002250 GO:0006914 GO:0006935 GO:0032392 GO:0051103 GO:0006310 GO:0006954 GO:0045087 GO:0002755 GO:0017055 GO:0006334 GO:1901224 GO:0034134 GO:0034142 | |
| Gene3D | 1.10.30.10 | |
| InterPro | IPR009071 IPR017967 IPR031076 | |
| PANTHER | PTHR13711:SF157 | |
| Pfam | PF00505 PF09011 | |
| SMART | SM00398 | |
| SUPFAM | SSF47095 | |
| PROSITE | PS00353 PS50118 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:1904877 |
positive regulation of DNA ligase activity |
ECO:0000314 |
P |
Figure 2 |
complete | |||||
|
involved_in |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034142 |
toll-like receptor 4 signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034134 |
toll-like receptor 2 signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002755 |
MyD88-dependent toll-like receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051106 |
positive regulation of DNA ligation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097350 |
neutrophil clearance |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043277 |
apoptotic cell clearance |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002840 |
regulation of T cell mediated immune response to tumor cell |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034165 |
positive regulation of toll-like receptor 9 signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002370) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006334 |
nucleosome assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002370) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005623 |
cell |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002370) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044378 |
non-sequence-specific DNA binding, bending |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032392 |
DNA geometric change |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0097100 |
supercoiled DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000405 |
bubble DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000400 |
four-way junction DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051103 |
DNA ligation involved in DNA repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0017055 |
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000793 |
condensed chromosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902741 |
positive regulation of interferon-alpha secretion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002672476 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1901224 |
positive regulation of NIK/NF-kappaB signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060326 |
cell chemotaxis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050718 |
positive regulation of interleukin-1 beta secretion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050716 |
positive regulation of interleukin-1 secretion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045089 |
positive regulation of innate immune response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032760 |
positive regulation of tumor necrosis factor production |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032755 |
positive regulation of interleukin-6 production |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032502 |
developmental process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010508 |
positive regulation of autophagy |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002672476 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008301 |
DNA binding, bending |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004362 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0278608 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0278608 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006338 |
chromatin remodeling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000345179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006310 |
DNA recombination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001009623 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96113 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002218 |
activation of innate immune response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002672476 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96157 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002250 |
adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006914 |
autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006310 |
DNA recombination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005793 |
endoplasmic reticulum-Golgi intermediate compartment |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Nagaki, S et al. (1998) Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks. Biochem. Biophys. Res. Commun. 246 137-41 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Park, JS et al. (2004) Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J. Biol. Chem. 279 7370-7 PubMed GONUTS page
- ↑ 3.0 3.1 Waga, S et al. (1989) Nonhistone proteins HMG1 and HMG2 suppress the nucleosome assembly at physiological ionic strength. Biochim. Biophys. Acta 1007 209-14 PubMed GONUTS page
- ↑ Yoshida, M (1987) High glutamic and aspartic region in nonhistone protein HMG(1+2) unwinds DNA double helical structure. J. Biochem. 101 175-80 PubMed GONUTS page
- ↑ Nakamura, Y et al. (2001) HMG box A in HMG2 protein functions as a mediator of DNA structural alteration together with box B. J. Biochem. 129 643-51 PubMed GONUTS page
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 6.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- GO:0005886 ! plasma membrane
- GO:1901224 ! positive regulation of non-canonical NF-kappaB signal transduction
- GO:0010508 ! positive regulation of autophagy
- GO:0032760 ! positive regulation of tumor necrosis factor production
- GO:0045089 ! positive regulation of innate immune response
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0050716 ! positive regulation of interleukin-1 secretion
- GO:0050718 ! positive regulation of interleukin-1 beta secretion
- GO:0070374 ! positive regulation of ERK1 and ERK2 cascade
- GO:1902741 ! positive regulation of interferon-alpha secretion
- GO:0034165 ! positive regulation of toll-like receptor 9 signaling pathway
- GO:0032755 ! positive regulation of interleukin-6 production
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